Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity

Autoren

Michèle Wessa
Andrea V King
Patric Meyer
Lutz Frölich
Herta Flor
Cyril Poupon
Michael Hoppstädter
Julia Linke

DOI

10.1007/s00429-015-1075-y

eISSN

1863-2661

ISSN

1863-2653

Ausgabe der Veröffentlichung

5

Zeitschrift

Brain Structure and Function

Sprache

en

Online publication date

2015

Paginierung

2831 - 2846

Datum der Veröffentlichung

2016

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1007/s00429-015-1075-y

Datum der Datenerfassung

2019

Titel

Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity

Ausgabe der Zeitschrift

221

Data source: Crossref

Abstract

Distinct lines of research demonstrated that patients with amnestic mild cognitive impairment (aMCI), a potential precursor of Alzheimer disease (AD), are particularly impaired in remembering relations between items and that the use of emotional targets can facilitate memory in patients with AD. We link these findings by examining learning through positive and negative feedback in patients with aMCI, and explore its anatomic underpinnings with diffusion tensor imaging and tractography. Compared to healthy controls, patients with single-domain aMCI were impaired in learning from positive feedback, while learning from negative outcomes was preserved. Among pathways within the brain circuit involved in feedback learning, abnormal white matter microstructure was observed in tracts, which connect left-hemispheric amygdala with hippocampus and entorhinal cortex. In all participants, reduced white matter integrity in this left fiber tract was specifically associated with learning from positive outcomes. Microstructure of right-hemispheric tracts between amygdala and entorhinal cortex was related to learning from negative feedback, and was not compromised in aMCI patients. Our results provide new insight into how anatomical connections might contribute to impaired and preserved aspects of learning behaviors in the early AD process and indicate potential compensatory mechanisms.

Addresses

Department of Clinical Psychology and Neuropsychology, Institute for Psychology, Johannes Gutenberg-University Mainz, Wallstraße 3, 55122, Mainz, Germany. wessa@uni-mainz.de.

Autoren

Michèle Wessa
Andrea V King
Patric Meyer
Lutz Frölich
Herta Flor
Cyril Poupon
Michael Hoppstädter
Julia Linke

DOI

10.1007/s00429-015-1075-y

eISSN

1863-2661

Externe Identifier

PubMed Identifier: 26084875

Funding acknowledgements

Deutsche Forschungsgemeinschaft: SFB 636/C6

Open access

false

ISSN

1863-2653

Ausgabe der Veröffentlichung

5

Zeitschrift

Brain structure & function

Schlüsselwörter

Brain
Amygdala
Hippocampus
Entorhinal Cortex
Neural Pathways
Humans
Amnesia
Magnetic Resonance Imaging
Aged
Middle Aged
Female
Male
Functional Laterality
Diffusion Tensor Imaging
White Matter
Formative Feedback
Cognitive Dysfunction

Sprache

eng

Medium

Print-Electronic

Online publication date

2015

Paginierung

2831 - 2846

Datum der Veröffentlichung

2016

Status

Published

Datum der Datenerfassung

2015

Titel

Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

221

Data source: Europe PubMed Central

Abstract

Distinct lines of research demonstrated that patients with amnestic mild cognitive impairment (aMCI), a potential precursor of Alzheimer disease (AD), are particularly impaired in remembering relations between items and that the use of emotional targets can facilitate memory in patients with AD. We link these findings by examining learning through positive and negative feedback in patients with aMCI, and explore its anatomic underpinnings with diffusion tensor imaging and tractography. Compared to healthy controls, patients with single-domain aMCI were impaired in learning from positive feedback, while learning from negative outcomes was preserved. Among pathways within the brain circuit involved in feedback learning, abnormal white matter microstructure was observed in tracts, which connect left-hemispheric amygdala with hippocampus and entorhinal cortex. In all participants, reduced white matter integrity in this left fiber tract was specifically associated with learning from positive outcomes. Microstructure of right-hemispheric tracts between amygdala and entorhinal cortex was related to learning from negative feedback, and was not compromised in aMCI patients. Our results provide new insight into how anatomical connections might contribute to impaired and preserved aspects of learning behaviors in the early AD process and indicate potential compensatory mechanisms.

Date of acceptance

2015

Autoren

Michèle Wessa
Andrea V King
Patric Meyer
Lutz Frölich
Herta Flor
Cyril Poupon
Michael Hoppstädter
Julia Linke

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/26084875

DOI

10.1007/s00429-015-1075-y

eISSN

1863-2661

Ausgabe der Veröffentlichung

5

Zeitschrift

Brain Struct Funct

Schlüsselwörter

Amnestic mild cognitive impairment
Amygdala
Diffusion tensor imaging
Entorhinal cortex
Hippocampus
Tractography
Aged
Amnesia
Amygdala
Brain
Cognitive Dysfunction
Diffusion Tensor Imaging
Entorhinal Cortex
Female
Formative Feedback
Functional Laterality
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
White Matter

Sprache

eng

Country

Germany

Paginierung

2831 - 2846

PII

10.1007/s00429-015-1075-y

Datum der Veröffentlichung

2016

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2017

Titel

Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

221

Data source: PubMed

Impaired and preserved aspects of feedback learning in aMCI: contributions of structural connectivity

Tools