Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder

Publication type:
Journal article
Metadata:
Autoren
  • Zhong Yi Sun
  • Josselin Houenou
  • Delphine Duclap
  • Samuel Sarrazin
  • Julia Linke
  • Claire Daban
  • Nora Hamdani
  • Marc-Antoine d'Albis
  • Philippe Le Corvoisier
  • Pamela Guevara
  • Marine Delavest
  • Frank Bellivier
  • Jorge Almeida
  • Amelia Versace
  • Cyril Poupon
  • Marion Leboyer
  • Mary Phillips
  • Michele Wessa
  • Jean-Francois Mangin
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000392404700005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1503/jpn.150291
eISSN
1488-2434
Externe Identifier
  • Clarivate Analytics Document Solution ID: EI3PW
  • PubMed Identifier: 28234596
ISSN
1180-4882
Ausgabe der Veröffentlichung
1
Zeitschrift
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
Paginierung
27 - 36
Datum der Veröffentlichung
2017
Status
Published
Titel
Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder
Sub types
  • Article
Ausgabe der Zeitschrift
42

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Zhong Yi Sun
  • Josselin Houenou
  • Delphine Duclap
  • Samuel Sarrazin
  • Julia Linke
  • Claire Daban
  • Nora Hamdani
  • Marc-Antoine d’Albis
  • Philippe Le Corvoisier
  • Pamela Guevara
  • Marine Delavest
  • Frank Bellivier
  • Jorge Almeida
  • Amelia Versace
  • Cyril Poupon
  • Marion Leboyer
  • Mary Phillips
  • Michèle Wessa
  • Jean-François Mangin
DOI
10.1503/jpn.150291
ISSN
1180-4882
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of Psychiatry & Neuroscience
Online publication date
2017
Paginierung
27 - 36
Datum der Veröffentlichung
2017
Status
Published
Herausgeber
CMA Joule Inc.
Herausgeber URL
http://dx.doi.org/10.1503/jpn.150291
Datum der Datenerfassung
2021
Titel
Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder
Ausgabe der Zeitschrift
42

Data source: Crossref

Abstract
<h4>Background</h4>Abnormal maturation of brain connectivity is supposed to underlie the dysfunctional emotion regulation in patients with bipolar disorder (BD). To test this hypothesis, white matter integrity is usually investigated using measures of water diffusivity provided by MRI. Here we consider a more intuitive aspect of the morphometry of the white matter tracts: the shape of the fibre bundles, which is associated with neurodevelopment. We analyzed the shape of 3 tracts involved in BD: the cingulum (CG), uncinate fasciculus (UF) and arcuate fasciculus (AF).<h4>Methods</h4>We analyzed diffusion MRI data in patients with BD and healthy controls. The fibre bundles were reconstructed using Q-ball-based tractography and automated segmentation. Using Isomap, a manifold learning method, the differences in the shape of the reconstructed bundles were visualized and quantified.<h4>Results</h4>We included 112 patients and 82 controls in our analysis. We found the left AF of patients to be further extended toward the temporal pole, forming a tighter hook than in controls. We found no significant difference in terms of shape for the left UF, the left CG or the 3 right fasciculi. However, in patients compared with controls, the ventrolateral branch of the left UF in the orbitofrontal region had a tendency to be larger, and the left CG of patients had a tendency to be smaller in the frontal lobe and larger in the parietal lobe.<h4>Limitations</h4>This was a cross-sectional study.<h4>Conclusion</h4>Our results suggest neurodevelopmental abnormalities in the left AF in patients with BD. The statistical tendencies observed for the left UF and left CG deserve further study.
Addresses
  • From the UNATI, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France (Sun, Mangin); the UNIACT, Psychiatry Team, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France (Houenou, Sarrazin); INSERM, U955, IMRB, Equipe 15 Psychiatrie Translationnelle, Créteil F-94000, France (Houenou, Sarrazin, Hamdani, d'Albis, Leboyer); the Fondation Fondamental, Créteil F-94010, France (Houenou, Sarrazin, Hamdani, d'Albis, Delavest, Bellivier, Leboyer); the AP-HP, Hôpitaux Universitaires Mondor, Pôle de Psychiatrie, DHU PePsy, Université Paris Est, Créteil F-94000, France (Sarrazin, Daban, Hamdani, d'Albis, Leboyer); the UNIRS, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France (Duclap, Poupon); the Department of Clinical Psychology and Neuropsychology, Johannes Gutenberg University, Mainz, Germany (Linke, Wessa); INSERM, Centre d'Investigation Clinique 1430 and APHP, GH Henri Mondor, Créteil F-94000, France (Le Corvoisier); the University of Concepción, Concepción, Chile (Guevara); the AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France (Delavest, Bellivier); the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medecine, Pittsburgh, PA, USA (Almeida, Versace, Phillips); the Faculté de médecine, Universite Paris Est, Créteil, France (Leboyer); and the CATI Multicenter Neuroimaging Platform, France (Sun, Poupon, Mangin).
Autoren
  • Zhong Yi Sun
  • Josselin Houenou
  • Delphine Duclap
  • Samuel Sarrazin
  • Julia Linke
  • Claire Daban
  • Nora Hamdani
  • Marc-Antoine d'Albis
  • Philippe Le Corvoisier
  • Pamela Guevara
  • Marine Delavest
  • Frank Bellivier
  • Frank Bellivier
  • Jorge Almeida
  • Amelia Versace
  • Cyril Poupon
  • Marion Leboyer
  • Mary Phillips
  • Michèle Wessa
  • Jean-François Mangin
DOI
10.1503/jpn.150291
eISSN
1488-2434
Externe Identifier
  • PubMed Identifier: 28234596
  • PubMed Central ID: PMC5373709
Funding acknowledgements
  • NIMH NIH HHS: R25 MH101076
  • NIMH NIH HHS: R01 MH076971
Open access
false
ISSN
1180-4882
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of psychiatry & neuroscience : JPN
Schlüsselwörter
  • Brain
  • Neural Pathways
  • Humans
  • Diffusion Magnetic Resonance Imaging
  • Cross-Sectional Studies
  • Bipolar Disorder
  • Image Processing, Computer-Assisted
  • Adolescent
  • Adult
  • Aged
  • Middle Aged
  • Female
  • Male
  • Young Adult
  • Machine Learning
Sprache
eng
Medium
Print
Paginierung
27 - 36
Datum der Veröffentlichung
2017
Status
Published
Datum der Datenerfassung
2017
Titel
Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Multicenter Study
  • Journal Article
  • Research Support, N.I.H., Extramural
Ausgabe der Zeitschrift
42

Files

http://jpn.ca/wp-content/uploads/2016/12/42-1-27.pdf https://europepmc.org/articles/PMC5373709?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: Abnormal maturation of brain connectivity is supposed to underlie the dysfunctional emotion regulation in patients with bipolar disorder (BD). To test this hypothesis, white matter integrity is usually investigated using measures of water diffusivity provided by MRI. Here we consider a more intuitive aspect of the morphometry of the white matter tracts: the shape of the fibre bundles, which is associated with neurodevelopment. We analyzed the shape of 3 tracts involved in BD: the cingulum (CG), uncinate fasciculus (UF) and arcuate fasciculus (AF). METHODS: We analyzed diffusion MRI data in patients with BD and healthy controls. The fibre bundles were reconstructed using Q-ball-based tractography and automated segmentation. Using Isomap, a manifold learning method, the differences in the shape of the reconstructed bundles were visualized and quantified. RESULTS: We included 112 patients and 82 controls in our analysis. We found the left AF of patients to be further extended toward the temporal pole, forming a tighter hook than in controls. We found no significant difference in terms of shape for the left UF, the left CG or the 3 right fasciculi. However, in patients compared with controls, the ventrolateral branch of the left UF in the orbitofrontal region had a tendency to be larger, and the left CG of patients had a tendency to be smaller in the frontal lobe and larger in the parietal lobe. LIMITATIONS: This was a cross-sectional study. CONCLUSION: Our results suggest neurodevelopmental abnormalities in the left AF in patients with BD. The statistical tendencies observed for the left UF and left CG deserve further study.
Autoren
  • Zhong Yi Sun
  • Josselin Houenou
  • Delphine Duclap
  • Samuel Sarrazin
  • Julia Linke
  • Claire Daban
  • Nora Hamdani
  • Marc-Antoine d'Albis
  • Philippe Le Corvoisier
  • Pamela Guevara
  • Marine Delavest
  • Frank Bellivier
  • Frank Bellivier
  • Jorge Almeida
  • Amelia Versace
  • Cyril Poupon
  • Marion Leboyer
  • Mary Phillips
  • Michèle Wessa
  • Jean-François Mangin
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/28234596
DOI
10.1503/jpn.150291
eISSN
1488-2434
Externe Identifier
  • PubMed Central ID: PMC5373709
Funding acknowledgements
  • NIMH NIH HHS: R01 MH076971
  • NIMH NIH HHS: R25 MH101076
Ausgabe der Veröffentlichung
1
Zeitschrift
J Psychiatry Neurosci
Schlüsselwörter
  • Adolescent
  • Adult
  • Aged
  • Bipolar Disorder
  • Brain
  • Cross-Sectional Studies
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Machine Learning
  • Male
  • Middle Aged
  • Neural Pathways
  • Young Adult
Sprache
eng
Country
Canada
Paginierung
27 - 36
PII
10.1503/jpn.150291
Datum der Veröffentlichung
2017
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder.
Sub types
  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
Ausgabe der Zeitschrift
42

Data source: PubMed

Beziehungen:
Property of

Tools