Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Vanessa Colligs
- Steven Peter Hansen
- Dennis Imbri
- Ean-Jeong Seo
- Onat Kadioglu
- Thomas Efferth
- Till Opatz
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000414184000007&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.bmc.2017.02.005
- eISSN
- 1464-3391
- Externe Identifier
- Clarivate Analytics Document Solution ID: FL4FN
- PubMed Identifier: 28233677
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- BIOORGANIC & MEDICINAL CHEMISTRY
- Schlüsselwörter
- Alkaloid synthesis
- Transition metal catalysis
- Natural product mimetics
- Antitumor activity
- Molecular docking
- Paginierung
- 6137 - 6148
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D
- Sub types
- Article
- Ausgabe der Zeitschrift
- 25
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Vanessa Colligs
- Steven Peter Hansen
- Dennis Imbri
- Ean-Jeong Seo
- Onat Kadioglu
- Thomas Efferth
- Till Opatz
- DOI
- 10.1016/j.bmc.2017.02.005
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Bioorganic & Medicinal Chemistry
- Sprache
- en
- Paginierung
- 6137 - 6148
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.bmc.2017.02.005
- Datum der Datenerfassung
- 2018
- Titel
- Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D
- Ausgabe der Zeitschrift
- 25
Data source: Crossref
- Abstract
- A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action towards a wild type and a multidrug resistant (MDR) cancer cell line. The compound was found to inhibit tumor cell growth at submicromolar concentrations and showed a lower relative resistance in the MDR cell line than the antitumor drug camptothecin to which lamellarin D shows cross resistance and with which lamellarin D shares the same binding site.
- Addresses
- Institute of Organic Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany.
- Autoren
- Vanessa Colligs
- Steven Peter Hansen
- Dennis Imbri
- Ean-Jeong Seo
- Onat Kadioglu
- Thomas Efferth
- Thomas Efferth
- Till Opatz
- DOI
- 10.1016/j.bmc.2017.02.005
- eISSN
- 1464-3391
- Externe Identifier
- PubMed Identifier: 28233677
- Funding acknowledgements
- Carl Zeiss Foundation:
- Open access
- false
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Bioorganic & medicinal chemistry
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Coumarins
- Isoquinolines
- DNA Topoisomerases, Type I
- Antineoplastic Agents
- Cell Survival
- Mutagenesis
- Binding Sites
- Protein Structure, Tertiary
- Drug Resistance, Neoplasm
- Topoisomerase I Inhibitors
- M Phase Cell Cycle Checkpoints
- G2 Phase Cell Cycle Checkpoints
- Molecular Docking Simulation
- Heterocyclic Compounds, 4 or More Rings
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2017
- Paginierung
- 6137 - 6148
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum der Datenerfassung
- 2017
- Titel
- Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 25
Data source: Europe PubMed Central
- Abstract
- A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action towards a wild type and a multidrug resistant (MDR) cancer cell line. The compound was found to inhibit tumor cell growth at submicromolar concentrations and showed a lower relative resistance in the MDR cell line than the antitumor drug camptothecin to which lamellarin D shows cross resistance and with which lamellarin D shares the same binding site.
- Date of acceptance
- 2017
- Autoren
- Vanessa Colligs
- Steven Peter Hansen
- Dennis Imbri
- Ean-Jeong Seo
- Onat Kadioglu
- Thomas Efferth
- Till Opatz
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28233677
- DOI
- 10.1016/j.bmc.2017.02.005
- eISSN
- 1464-3391
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Bioorg Med Chem
- Schlüsselwörter
- Alkaloid synthesis
- Antitumor activity
- Molecular docking
- Natural product mimetics
- Transition metal catalysis
- Antineoplastic Agents
- Binding Sites
- Cell Line, Tumor
- Cell Survival
- Coumarins
- DNA Topoisomerases, Type I
- Drug Resistance, Neoplasm
- G2 Phase Cell Cycle Checkpoints
- Heterocyclic Compounds, 4 or More Rings
- Humans
- Isoquinolines
- M Phase Cell Cycle Checkpoints
- Molecular Docking Simulation
- Mutagenesis
- Protein Structure, Tertiary
- Topoisomerase I Inhibitors
- Sprache
- eng
- Country
- England
- Paginierung
- 6137 - 6148
- PII
- S0968-0896(16)31109-9
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 25
Data source: PubMed
- Beziehungen:
- Property of