Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from Sequoia sempervirens (D. Don Endl)
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- SS El-Hawary
- EM Abd El-Kader
- MA Rabeh
- GA Abdel Jaleel
- MA Arafat
- Tanja Schirmeister
- Usama Ramadan Abdelmohsen
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000472879300001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/14786419.2019.1607334
- eISSN
- 1478-6427
- Externe Identifier
- Clarivate Analytics Document Solution ID: OI0CK
- PubMed Identifier: 31230477
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- NATURAL PRODUCT RESEARCH
- Schlüsselwörter
- Sequoia sempervirens
- callus culture
- elicitors
- flavonoids
- HPLC
- hepatoprotective
- Paginierung
- 3125 - 3129
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from <i>Sequoia sempervirens</i> (D. Don Endl)
- Sub types
- Article
- Ausgabe der Zeitschrift
- 34
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- SS El-Hawary
- EM Abd El-Kader
- MA Rabeh
- GA Abdel Jaleel
- MA Arafat
- Tanja Schirmeister
- Usama Ramadan Abdelmohsen
- DOI
- 10.1080/14786419.2019.1607334
- eISSN
- 1478-6427
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- Natural Product Research
- Sprache
- en
- Online publication date
- 2019
- Paginierung
- 3125 - 3129
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/14786419.2019.1607334
- Datum der Datenerfassung
- 2020
- Titel
- Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from <i>Sequoia sempervirens</i> (D. Don Endl)
- Ausgabe der Zeitschrift
- 34
Data source: Crossref
- Abstract
- The aim of our study is to estimate the hepatoprotective effects of the ethanolic extract of the leaves of <i>Sequoia sempervirens</i> by determination of liver biomarkers (ALT, AST, total bilirubin and albumin in serum) and by histopathological examinations using thioacetamide-induced (TAA) liver injury model. Concurrent administration of ethanolic extracts of <i>S. sempervirens</i> leaves improved the alterations in liver morphology where it was a potent protector of the liver. The potential of L-phenylalanine and silver nitrate as chemical elicitors as well as UV radiation as a physical elicitor on flavonoid production in callus culture of <i>S. sempervirens</i> were emphasized. Murashige and Skoog's medium fortified with phenylalanine and silver nitrate enhanced the production of flavonoids and phenolics. HPLC analysis was performed for qualitative and quantitative estimation of some flavonoid compounds in the produced calli in comparison with the mother plant. This finding highlights the potential use of <i>S. sempervirens</i> in the treatment of liver dysfunction.
- Addresses
- Department of Pharmacognosy Faculty of pharmacy, Cairo University, Cairo, Egypt.
- Autoren
- SS El-Hawary
- EM Abd El-Kader
- MA Rabeh
- GA Abdel Jaleel
- MA Arafat
- Tanja Schirmeister
- Usama Ramadan Abdelmohsen
- DOI
- 10.1080/14786419.2019.1607334
- eISSN
- 1478-6427
- Externe Identifier
- PubMed Identifier: 31230477
- Open access
- false
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- Natural product research
- Schlüsselwörter
- Liver
- Animals
- Mice
- Rats, Wistar
- Sequoia
- Plant Leaves
- Liver Diseases
- Thioacetamide
- Phenols
- Flavonoids
- Plant Extracts
- Protective Agents
- Culture Media
- Chromatography, High Pressure Liquid
- Tissue Culture Techniques
- Male
- Chemical and Drug Induced Liver Injury
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2019
- Paginierung
- 3125 - 3129
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum der Datenerfassung
- 2019
- Titel
- Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from <i>Sequoia sempervirens</i> (D. Don Endl).
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 34
Data source: Europe PubMed Central
- Abstract
- The aim of our study is to estimate the hepatoprotective effects of the ethanolic extract of the leaves of Sequoia sempervirens by determination of liver biomarkers (ALT, AST, total bilirubin and albumin in serum) and by histopathological examinations using thioacetamide-induced (TAA) liver injury model. Concurrent administration of ethanolic extracts of S. sempervirens leaves improved the alterations in liver morphology where it was a potent protector of the liver. The potential of L-phenylalanine and silver nitrate as chemical elicitors as well as UV radiation as a physical elicitor on flavonoid production in callus culture of S. sempervirens were emphasized. Murashige and Skoog's medium fortified with phenylalanine and silver nitrate enhanced the production of flavonoids and phenolics. HPLC analysis was performed for qualitative and quantitative estimation of some flavonoid compounds in the produced calli in comparison with the mother plant. This finding highlights the potential use of S. sempervirens in the treatment of liver dysfunction.
- Autoren
- SS El-Hawary
- EM Abd El-Kader
- MA Rabeh
- GA Abdel Jaleel
- MA Arafat
- Tanja Schirmeister
- Usama Ramadan Abdelmohsen
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/31230477
- DOI
- 10.1080/14786419.2019.1607334
- eISSN
- 1478-6427
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- Nat Prod Res
- Schlüsselwörter
- HPLC
- Sequoia sempervirens
- callus culture
- elicitors
- flavonoids
- hepatoprotective
- Animals
- Chemical and Drug Induced Liver Injury
- Chromatography, High Pressure Liquid
- Culture Media
- Flavonoids
- Liver
- Liver Diseases
- Male
- Mice
- Phenols
- Plant Extracts
- Plant Leaves
- Protective Agents
- Rats, Wistar
- Sequoia
- Thioacetamide
- Tissue Culture Techniques
- Sprache
- eng
- Country
- England
- Paginierung
- 3125 - 3129
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from Sequoia sempervirens (D. Don Endl).
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 34
Data source: PubMed
- Autoren
- SS El-Hawary
- EM Abd El-Kader
- MA Rabeh
- GA Abdel Jaleel
- MA Arafat
- Tanja Schirmeister
- Usama Ramadan Abdelmohsen
- Zeitschrift
- Natural product research
- Artikelnummer
- 21
- Paginierung
- 3125 - 3129
- Datum der Veröffentlichung
- 2020
- Herausgeber
- Taylor & Francis
- Datum der Datenerfassung
- 2021
- Titel
- Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from Sequoia sempervirens (D. Don Endl)
- Sub types
- article
- Ausgabe der Zeitschrift
- 34
Data source: Manual
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- Property of