Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges

Publication type:
Journal article
Metadata:
Autoren
  • Paula Tabares
  • Sheila M Pimentel-Elardo
  • Tanja Schirmeister
  • Thomas Huenig
  • Ute Hentschel
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000293970600007&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1007/s10126-010-9349-0
Externe Identifier
  • Clarivate Analytics Document Solution ID: 808IE
  • PubMed Identifier: 21222136
ISSN
1436-2228
Ausgabe der Veröffentlichung
5
Zeitschrift
MARINE BIOTECHNOLOGY
Schlüsselwörter
  • Actinomycetes
  • Sphingomonads
  • Marine sponge
  • Anti-protease
  • Immunomodulatory
  • Phylogenetic analysis
Paginierung
883 - 892
Datum der Veröffentlichung
2011
Status
Published
Titel
Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges
Sub types
  • Article
Ausgabe der Zeitschrift
13

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Paula Tabares
  • Sheila M Pimentel-Elardo
  • Tanja Schirmeister
  • Thomas Hünig
  • Ute Hentschel
DOI
10.1007/s10126-010-9349-0
eISSN
1436-2236
ISSN
1436-2228
Ausgabe der Veröffentlichung
5
Zeitschrift
Marine Biotechnology
Sprache
en
Online publication date
2011
Paginierung
883 - 892
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s10126-010-9349-0
Datum der Datenerfassung
2020
Titel
Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges
Ausgabe der Zeitschrift
13

Data source: Crossref

Abstract
Marine sponges and their associated bacteria have been proven to be a rich source of novel secondary metabolites with therapeutic usefulness in cancer, infection, and autoimmunity. In this study, 79 strains belonging to 20 genera of the order Actinomycetales and seven strains belonging to two genera of the order Sphingomonadales were cultivated from 18 different Caribbean sponges and identified by 16S rRNA gene sequencing. Seven of these strains are likely to represent novel species. Crude extracts from selected strains were found to exhibit protease inhibition against cathepsins B and L, rhodesain, and falcipain-2 as well as immunomodulatory activities such as induction of cytokine release by human peripheral blood mononuclear cells. These results highlight the significance of marine sponge-associated bacteria to produce bioactive secondary metabolites with therapeutic potential in the treatment of infectious diseases and disorders of the immune system.
Addresses
  • Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany.
Autoren
  • Paula Tabares
  • Sheila M Pimentel-Elardo
  • Tanja Schirmeister
  • Thomas Hünig
  • Ute Hentschel
DOI
10.1007/s10126-010-9349-0
eISSN
1436-2236
Externe Identifier
  • PubMed Identifier: 21222136
  • PubMed Central ID: PMC7088305
Open access
true
ISSN
1436-2228
Ausgabe der Veröffentlichung
5
Zeitschrift
Marine biotechnology (New York, N.Y.)
Schlüsselwörter
  • Animals
  • Porifera
  • Actinomycetales
  • Alphaproteobacteria
  • RNA, Bacterial
  • RNA, Ribosomal, 16S
  • Immunologic Factors
  • Protease Inhibitors
  • Gene Expression Regulation, Bacterial
  • Caribbean Region
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Open access status
Open Access
Paginierung
883 - 892
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Anti-protease and immunomodulatory activities of bacteria associated with Caribbean sponges.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
13

Files

https://link.springer.com/content/pdf/10.1007/s10126-010-9349-0.pdf https://europepmc.org/articles/PMC7088305?pdf=render

Data source: Europe PubMed Central

Abstract
Marine sponges and their associated bacteria have been proven to be a rich source of novel secondary metabolites with therapeutic usefulness in cancer, infection, and autoimmunity. In this study, 79 strains belonging to 20 genera of the order Actinomycetales and seven strains belonging to two genera of the order Sphingomonadales were cultivated from 18 different Caribbean sponges and identified by 16S rRNA gene sequencing. Seven of these strains are likely to represent novel species. Crude extracts from selected strains were found to exhibit protease inhibition against cathepsins B and L, rhodesain, and falcipain-2 as well as immunomodulatory activities such as induction of cytokine release by human peripheral blood mononuclear cells. These results highlight the significance of marine sponge-associated bacteria to produce bioactive secondary metabolites with therapeutic potential in the treatment of infectious diseases and disorders of the immune system.
Date of acceptance
2010
Autoren
  • Paula Tabares
  • Sheila M Pimentel-Elardo
  • Tanja Schirmeister
  • Thomas Hünig
  • Ute Hentschel
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21222136
DOI
10.1007/s10126-010-9349-0
eISSN
1436-2236
Externe Identifier
  • PubMed Central ID: PMC7088305
Ausgabe der Veröffentlichung
5
Zeitschrift
Mar Biotechnol (NY)
Schlüsselwörter
  • Actinomycetales
  • Alphaproteobacteria
  • Animals
  • Caribbean Region
  • Gene Expression Regulation, Bacterial
  • Immunologic Factors
  • Porifera
  • Protease Inhibitors
  • RNA, Bacterial
  • RNA, Ribosomal, 16S
Sprache
eng
Country
United States
Paginierung
883 - 892
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Anti-protease and immunomodulatory activities of bacteria associated with Caribbean sponges.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
13

Data source: PubMed

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