Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Lukas Schwentner
- Achim Woeckel
- Jochem Koenig
- Wolfgang Janni
- Florian Ebner
- Maria Blettner
- Rolf Kreienberg
- Reyn Van Ewijk
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000329024100001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1186/1471-2407-13-487
- eISSN
- 1471-2407
- Externe Identifier
- Clarivate Analytics Document Solution ID: 280JE
- PubMed Identifier: 24138748
- Zeitschrift
- BMC CANCER
- Schlüsselwörter
- Breast cancer
- Guideline
- Survival
- Triple negative
- Cohort study
- Artikelnummer
- ARTN 487
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients
- Sub types
- Article
- Ausgabe der Zeitschrift
- 13
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Lukas Schwentner
- Achim Wöckel
- Jochem König
- Wolfgang Janni
- Florian Ebner
- Maria Blettner
- Rolf Kreienberg
- Reyn Van Ewijk
- DOI
- 10.1186/1471-2407-13-487
- eISSN
- 1471-2407
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- BMC Cancer
- Sprache
- en
- Artikelnummer
- 487
- Online publication date
- 2013
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/1471-2407-13-487
- Datum der Datenerfassung
- 2020
- Titel
- Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients
- Ausgabe der Zeitschrift
- 13
Data source: Crossref
- Abstract
- <h4>Background</h4>Triple-negative breast cancer (TNBC) remains a challenging topic for clinical oncologists. This study sought to evaluate TNBC versus other breast cancer subtypes with respect to survival parameters. We evaluated possible differences in survival in TNBC by age and by the extent to which evidence-based treatment guidelines were adhered.<h4>Methods</h4>This German retrospective multi-center cohort study included 9156 patients with primary breast cancer recruited from 1992 to 2008.<h4>Results</h4>The rates of guideline adherence are significantly lower in TNBC compared to non-TNBC subtypes. These lower rates of guideline adherence can be observed in all age groups and are most pronounced in the >65 subgroup [<50 (20.9% vs. 42.0%), 50-64 (25.1% vs. 51.1%), and >65 (38.4% vs. 74.6%)]. In TNBC patients of all age groups, disease-free survival and overall survival were associated with an improvement by 100% guideline-adherent adjuvant treatment compared to non-adherence. Furthermore, TNBC patients of all ages had similar outcome parameters if 100% guideline-adherent adjuvant treatment was applied.<h4>Conclusion</h4>The rates of guideline-adherent treatment were significantly lower in TNBC, even though guideline adherence was strongly associated with improved survival. In the case of 100% guideline-adherent treatment, no difference in survival was observed over all the age groups examined, even in the group of >65-year-old TNBC patients.
- Addresses
- Department of Gynecology and Obstetrics, University Ulm, Prittwitzstraße 43, Ulm 89075, Germany. lukas.schwentner@yahoo.de.
- Autoren
- Lukas Schwentner
- Achim Wöckel
- Jochem König
- Wolfgang Janni
- Florian Ebner
- Maria Blettner
- Rolf Kreienberg
- Reyn Van Ewijk
- Brenda study group
- DOI
- 10.1186/1471-2407-13-487
- eISSN
- 1471-2407
- Externe Identifier
- PubMed Identifier: 24138748
- PubMed Central ID: PMC3815231
- Open access
- true
- ISSN
- 1471-2407
- Zeitschrift
- BMC cancer
- Schlüsselwörter
- Brenda study group
- Humans
- Lymphatic Metastasis
- Neoplasm Staging
- Treatment Outcome
- Retrospective Studies
- Adult
- Aged
- Aged, 80 and over
- Middle Aged
- Guideline Adherence
- Female
- Practice Guidelines as Topic
- Young Adult
- Triple Negative Breast Neoplasms
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2013
- Open access status
- Open Access
- Paginierung
- 487
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2013
- Titel
- Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9,156 patients.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Multicenter Study
- Journal Article
- Ausgabe der Zeitschrift
- 13
Files
https://bmccancer.biomedcentral.com/track/pdf/10.1186/1471-2407-13-487 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24138748/pdf/?tool=EBI https://europepmc.org/articles/PMC3815231?pdf=render
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Triple-negative breast cancer (TNBC) remains a challenging topic for clinical oncologists. This study sought to evaluate TNBC versus other breast cancer subtypes with respect to survival parameters. We evaluated possible differences in survival in TNBC by age and by the extent to which evidence-based treatment guidelines were adhered. METHODS: This German retrospective multi-center cohort study included 9156 patients with primary breast cancer recruited from 1992 to 2008. RESULTS: The rates of guideline adherence are significantly lower in TNBC compared to non-TNBC subtypes. These lower rates of guideline adherence can be observed in all age groups and are most pronounced in the >65 subgroup [<50 (20.9% vs. 42.0%), 50-64 (25.1% vs. 51.1%), and >65 (38.4% vs. 74.6%)]. In TNBC patients of all age groups, disease-free survival and overall survival were associated with an improvement by 100% guideline-adherent adjuvant treatment compared to non-adherence. Furthermore, TNBC patients of all ages had similar outcome parameters if 100% guideline-adherent adjuvant treatment was applied. CONCLUSION: The rates of guideline-adherent treatment were significantly lower in TNBC, even though guideline adherence was strongly associated with improved survival. In the case of 100% guideline-adherent treatment, no difference in survival was observed over all the age groups examined, even in the group of >65-year-old TNBC patients.
- Date of acceptance
- 2013
- Autoren
- Lukas Schwentner
- Achim Wöckel
- Jochem König
- Wolfgang Janni
- Florian Ebner
- Maria Blettner
- Rolf Kreienberg
- Reyn Van Ewijk
- Brenda study group
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/24138748
- DOI
- 10.1186/1471-2407-13-487
- eISSN
- 1471-2407
- Externe Identifier
- PubMed Central ID: PMC3815231
- Zeitschrift
- BMC Cancer
- Schlüsselwörter
- Adult
- Aged
- Aged, 80 and over
- Female
- Guideline Adherence
- Humans
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Staging
- Practice Guidelines as Topic
- Retrospective Studies
- Treatment Outcome
- Triple Negative Breast Neoplasms
- Young Adult
- Sprache
- eng
- Country
- England
- Paginierung
- 487
- PII
- 1471-2407-13-487
- Datum der Veröffentlichung
- 2013
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9,156 patients.
- Sub types
- Journal Article
- Multicenter Study
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 13
Data source: PubMed
- Beziehungen:
- Property of