Development of an easy-to-use mass spectrometric technique to monitor solid-phase reactions on polystyrene supports
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- K Heinze
- U Winterhalter
- T Jannack
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000165578400018&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/1521-3765(20001117)6:22<4203::AID-CHEM4203>3.0.CO;2-Q
- Externe Identifier
- Clarivate Analytics Document Solution ID: 378HF
- PubMed Identifier: 11128285
- ISSN
- 0947-6539
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- CHEMISTRY-A EUROPEAN JOURNAL
- Schlüsselwörter
- IR spectroscopy
- kinetics
- mass spectrometry
- polystyrene
- solid-phase synthesis
- Paginierung
- 4203 - 4210
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Titel
- Development of an easy-to-use mass spectrometric technique to monitor solid-phase reactions on polystyrene supports
- Sub types
- Article
- Ausgabe der Zeitschrift
- 6
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Katja Heinze
- Ute Winterhalter
- Thomas Jannack
- DOI
- 10.1002/1521-3765(20001117)6:22<4203::aid-chem4203>3.0.co;2-q
- eISSN
- 1521-3765
- ISSN
- 0947-6539
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Chemistry
- Sprache
- en
- Paginierung
- 4203 - 4210
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/1521-3765(20001117)6:22%3C4203::aid-chem4203%3E3.0.co;2-q
- Datum der Datenerfassung
- 2021
- Titel
- Development of an Easy-to-Use Mass Spectrometric Technique to Monitor Solid-Phase Reactions on Polystyrene Supports
- Ausgabe der Zeitschrift
- 6
Data source: Crossref
- Abstract
- By using mass spectrometry as an analytical tool to characterise substituted, cross-linked polystyrene resins, it is possible to directly monitor the progress of the solid-phase reactions performed on these resins without prior cleavage of the resin-bound molecules. Therefore, this is a true on-resin analytical method. The mass-to-charge ratios observed in the mass spectra are readily assigned to fragments of the polymer that include the chemically bound substituents. This is the first time that the formation and breaking of bonds have been directly observed on the polymeric support. Furthermore, the relative intensities of the signals in the mass spectra provide a measure of the completeness of the reaction. Because these measurements are rapidly performed without further chemical transformations or cleavage procedures, and because only minimal amounts of material are needed, this technique could become the solid-phase equivalent of thin-layer chromatography used in classical liquid-phase chemistry.
- Addresses
- Anorganisch-Chemisches Institut der Universität Heidelberg, Germany. katja@sun0.urz.uni-heidelberg.de
- Autoren
- K Heinze
- U Winterhalter
- T Jannack
- DOI
- 10.1002/1521-3765(20001117)6:22<4203::aid-chem4203>3.0.co;2-q
- eISSN
- 1521-3765
- Externe Identifier
- PubMed Identifier: 11128285
- Open access
- false
- ISSN
- 0947-6539
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Sprache
- eng
- Medium
- Paginierung
- 4203 - 4210
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Datum der Datenerfassung
- 2000
- Titel
- Development of an easy-to-use mass spectrometric technique to monitor solid-phase reactions on polystyrene supports.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 6
Data source: Europe PubMed Central
- Abstract
- By using mass spectrometry as an analytical tool to characterise substituted, cross-linked polystyrene resins, it is possible to directly monitor the progress of the solid-phase reactions performed on these resins without prior cleavage of the resin-bound molecules. Therefore, this is a true on-resin analytical method. The mass-to-charge ratios observed in the mass spectra are readily assigned to fragments of the polymer that include the chemically bound substituents. This is the first time that the formation and breaking of bonds have been directly observed on the polymeric support. Furthermore, the relative intensities of the signals in the mass spectra provide a measure of the completeness of the reaction. Because these measurements are rapidly performed without further chemical transformations or cleavage procedures, and because only minimal amounts of material are needed, this technique could become the solid-phase equivalent of thin-layer chromatography used in classical liquid-phase chemistry.
- Autoren
- K Heinze
- U Winterhalter
- T Jannack
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/11128285
- DOI
- 10.1002/1521-3765(20001117)6:22<4203::aid-chem4203>3.0.co;2-q
- ISSN
- 0947-6539
- Ausgabe der Veröffentlichung
- 22
- Zeitschrift
- Chemistry
- Sprache
- eng
- Country
- Germany
- Paginierung
- 4203 - 4210
- PII
- 10.1002/1521-3765(20001117)6:22<4203::AID-CHEM4203>3.0.CO;2-Q
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2001
- Titel
- Development of an easy-to-use mass spectrometric technique to monitor solid-phase reactions on polystyrene supports.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 6
Data source: PubMed
- Beziehungen:
-