Promotion of Arterial Stiffness by Childhood Cancer and Its Characteristics in Adult Long‐Term Survivors

Publication type:
Journal article
Metadata:
Abstract
<jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en">Vascular alterations induced by antineoplastic treatment might be considered as a possible underlying mechanism of increased cardiovascular sequelae in childhood cancer survivors (CCSs). We aimed to evaluate arterial stiffness among long‐term CCSs and to compare the data against a population‐based sample.</jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en">Arterial stiffness was assessed by digital photoplethysmography (stiffness index; m/s) among 1002 participants of the CVSS (Cardiac and Vascular Late Sequelae in Long‐Term Survivors of Childhood Cancer) study, diagnosed with neoplasia (1980–1990) before an age of 15 years. A population‐based sample from the GHS (Gutenberg Health Study) (n=5252) was investigated for comparison. All subjects underwent a comprehensive, standardized clinical examination in the same study center. CCSs had higher stiffness index (β=0.66 m/s; 95% CI, 0.51–0.80 m/s) in multivariable linear regression analysis after adjustment for cardiovascular risk factors compared with the population sample of comparable age range. Stiffer vessels were found among CCSs also in absence of arterial hypertension (β=0.66; 95% CI, 0.50–0.81) or history of chemotherapy/radiotherapy (β=0.56; 95% CI, 0.16–0.96) in fully adjusted models. Moreover, stiffness index differed by tumor entity, with highest values in bone and renal tumors. Almost 5.2‐fold higher prevalence of stiffness index values exceeding age‐specific, population‐based reference limits was observed among CCSs compared with GHS participants.</jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en">This is the first study demonstrating increased arterial stiffness among long‐term CCSs. The data suggest that vascular compliance might differ in survivors of childhood cancer from the established development concept for arterial stiffness in the population; cancer growth and antineoplastic treatment might be relevant determinants of the pathobiological features.</jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Registration</jats:title> <jats:p xml:lang="en"> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.clinicaltrials.gov">https://www.clinicaltrials.gov</jats:ext-link> ; Unique identifier: NCT02181049. </jats:p> </jats:sec>
Autoren
  • Natalie Arnold
  • Hiltrud Merzenich
  • Arthur Wingerter
  • Andreas Schulz
  • Astrid Schneider
  • Jürgen H Prochaska
  • Sebastian Göbel
  • Marie A Neu
  • Nicole Henninger
  • Marina Panova‐Noeva
  • Susan Eckerle
  • Claudia Spix
  • Irene Schmidtmann
  • Karl J Lackner
  • Manfred E Beutel
  • Norbert Pfeiffer
  • Thomas Münzel
  • Jörg Faber
  • Philipp S Wild
DOI
10.1161/jaha.119.015609
eISSN
2047-9980
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of the American Heart Association
Sprache
en
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Ovid Technologies (Wolters Kluwer Health)
Herausgeber URL
http://dx.doi.org/10.1161/jaha.119.015609
Datum der Datenerfassung
2024
Titel
Promotion of Arterial Stiffness by Childhood Cancer and Its Characteristics in Adult Long‐Term Survivors
Ausgabe der Zeitschrift
10

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY-NC-ND
Autoren
  • Natalie Arnold
  • Hiltrud Merzenich
  • Arthur Wingerter
  • Andreas Schulz
  • Astrid Schneider
  • Jürgen H Prochaska
  • Sebastian Göbel
  • Marie A Neu
  • Nicole Henninger
  • Marina Panova-Noeva
  • Susan Eckerle
  • Claudia Spix
  • Irene Schmidtmann
  • Karl J Lackner
  • Manfred E Beutel
  • Norbert Pfeiffer
  • Thomas Münzel
  • Jörg Faber
  • Philipp S Wild
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1161/JAHA.119.015609
Funding acknowledgements
  • Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz
File(s) embargoed
false
Open access
true
ISSN
2047-9980
Ausgabe der Veröffentlichung
5
Zeitschrift
Journal of the American Heart Association
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
e015609
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/6220
Herausgeber
Association
Herausgeber URL
https://doi.org/10.1161/JAHA.119.015609
Datum der Datenerfassung
2021
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Zugang
Public
Titel
Promotion of arterial stiffness by childhood cancer and its characteristics in adult long‐term survivors
Ausgabe der Zeitschrift
10

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arnold_natalie-promotion_of_a-20211105134418161.pdf

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