NMR Hyperpolarization of established PET tracers

Publication type:
Journal article
Metadata:
Autoren
  • Manuel Braun
  • Sascha Haeseli
  • Frank Roesch
  • Markus Piel
  • Kerstin Muennemann
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000432225900025&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/slct.201800364
Externe Identifier
  • Clarivate Analytics Document Solution ID: GF8MG
ISSN
2365-6549
Ausgabe der Veröffentlichung
18
Zeitschrift
CHEMISTRYSELECT
Schlüsselwörter
  • Hydrogenation
  • Imaging agents
  • NMR Hyperpolarization
  • Para-hydrogen induced polarization
  • Positron emission tomography
Paginierung
5176 - 5184
Datum der Veröffentlichung
2018
Status
Published
Titel
NMR Hyperpolarization of Established PET Tracers
Sub types
  • Article
Ausgabe der Zeitschrift
3

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>The development of sensitive probes for directly measuring <jats:italic>in vivo</jats:italic> processes is at the forefront of medical imaging. In the case of magnetic resonance imaging (MRI) the detection of a small number of molecules is a major challenge due to its limited sensitivity. This problem can be tackled by hyperpolarization, which increases the NMR signals up to several orders of magnitude. In this contribution NMR hyperpolarization of non‐radioactive counterparts of two well‐established positron emission tomography (PET) tracers, namely <jats:italic>O</jats:italic>‐(2‐[<jats:sup>18</jats:sup>F]fluoroethyl)‐<jats:sc>l</jats:sc>‐tyrosine ([<jats:sup>18</jats:sup>F]FET) and [<jats:sup>18</jats:sup>F]fallypride ([<jats:sup>18</jats:sup>F]FP), via para‐hydrogen induced polarization (PHIP), to investigate oncological and neurological questions is demonstrated. Significant <jats:sup>1</jats:sup>H/<jats:sup>13</jats:sup>C NMR signal enhancements of several thousand were achieved for both tracers. Partial deuteration of the <jats:sup>13</jats:sup>C‐labeled [<jats:sup>18</jats:sup>F]FET analog resulted in T<jats:sub>1</jats:sub> times up to ∼36 s. Hence, this molecule is a candidate for an MRI contrast agent, allowing follow‐up MRI examinations with close succession in time.</jats:p>
Autoren
  • Manuel Braun
  • Sascha Häseli
  • Frank Rösch
  • Markus Piel
  • Kerstin Münnemann
DOI
10.1002/slct.201800364
eISSN
2365-6549
ISSN
2365-6549
Ausgabe der Veröffentlichung
18
Zeitschrift
ChemistrySelect
Sprache
en
Online publication date
2018
Paginierung
5176 - 5184
Datum der Veröffentlichung
2018
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/slct.201800364
Datum der Datenerfassung
2023
Titel
NMR Hyperpolarization of Established PET Tracers
Ausgabe der Zeitschrift
3

Data source: Crossref

Autoren
  • Manuel Braun
  • Sascha Häseli
  • Frank Rösch
  • Markus Piel
  • Kerstin Münnemann
Zeitschrift
ChemistrySelect
Artikelnummer
18
Paginierung
5176 - 5184
Datum der Veröffentlichung
2018
Datum der Datenerfassung
2021
Titel
NMR Hyperpolarization of established PET tracers
Sub types
  • article
Ausgabe der Zeitschrift
3

Data source: Manual

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