Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: An [18F] fallypride PET study

Publication type:
Journal article
Metadata:
Autoren
  • Konrad J Werhahn
  • Christian Landvogt
  • Sven Klimpe
  • Hans-Georg Buchholz
  • Igor Yakushev
  • Thomas Siessmeier
  • Wibke Mueller-Forell
  • Markus Piel
  • Frank Roesch
  • Martin Glaser
  • Mathias Schreckenberger
  • Peter Bartenstein
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000239636100017&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1111/j.1528-1167.2006.00561.x
Externe Identifier
  • Clarivate Analytics Document Solution ID: 071XB
  • PubMed Identifier: 16922886
ISSN
0013-9580
Ausgabe der Veröffentlichung
8
Zeitschrift
EPILEPSIA
Paginierung
1392 - 1396
Datum der Veröffentlichung
2006
Status
Published
Titel
Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy:: An [<SUP>18</SUP>F]Fallypride PET study
Sub types
  • Article
Ausgabe der Zeitschrift
47

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p><jats:bold>Summary: </jats:bold> <jats:italic>Purpose:</jats:italic> Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing.</jats:p><jats:p> <jats:italic>Methods:</jats:italic> To quantify D2/D3‐receptor density, we studied seven patients with temporal lobe epilepsy (TLE) and nine age‐matched controls with positron emission tomography (PET) by using the high‐affinity dopamine D2/D3‐receptor ligand [<jats:sup>18</jats:sup>F]Fallypride ([<jats:sup>18</jats:sup>F]FP) suitable for imaging extrastriatal binding. TLE was defined by interictal and ictal video‐EEG, magnetic resonance imaging (MRI), and [<jats:sup>18</jats:sup>F]fluorodeoxyglucose ([<jats:sup>18</jats:sup>F]FDG)‐PET and was due to hippocampal sclerosis (HS), based on histology in all patients. Primary analysis was based on regions of interest (ROIs) defined on individual MRIs. For each patient, binding potential (BP) was calculated by using the simplified reference tissue model, and the epileptogenic was compared with the unaffected hemisphere in each ROI. To confirm the results, an additional voxel‐based group analysis was performed by using statistical parametric mapping.</jats:p><jats:p> <jats:italic>Results:</jats:italic> Compared with controls, [<jats:sup>18</jats:sup>F]FP BP was significantly decreased in the epileptogenic temporal lobe in all patients. On ROI analysis, this reduction was evident in areas surrounding the seizure‐onset zone at the pole (–34.2%) and lateral aspects (–32.9%) of the temporal lobe. Although the hippocampus [<jats:sup>18</jats:sup>F]FDG uptake (–8.1%) and hippocampal MR volume (–35.1%) were significantly reduced, no significant decrease of [<jats:sup>18</jats:sup>F]FP BP was found. Reduction of [<jats:sup>18</jats:sup>F]FP BP did not correlate with hippocampal atrophy.</jats:p><jats:p> <jats:italic>Conclusions:</jats:italic> D2/D3‐receptor binding is reduced at the pole and in lateral aspects of the epileptogenic temporal lobe in patients with mesial TLE and HS. This area might correspond to “the irritative zone,” indicating that D2/D3 receptors might play a specific role in the pathophysiology of mesial TLE.</jats:p>
Autoren
  • Konrad J Werhahn
  • Christian Landvogt
  • Sven Klimpe
  • Hans‐Georg Buchholz
  • Igor Yakushev
  • Thomas Siessmeier
  • Wibke Müller‐Forell
  • Markus Piel
  • Frank Rösch
  • Martin Glaser
  • Mathias Schreckenberger
  • Peter Bartenstein
DOI
10.1111/j.1528-1167.2006.00561.x
eISSN
1528-1167
ISSN
0013-9580
Ausgabe der Veröffentlichung
8
Zeitschrift
Epilepsia
Sprache
en
Online publication date
2006
Paginierung
1392 - 1396
Datum der Veröffentlichung
2006
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/j.1528-1167.2006.00561.x
Datum der Datenerfassung
2023
Titel
Decreased Dopamine D2/D3‐Receptor Binding in Temporal Lobe Epilepsy: An [<sup>18</sup>F]Fallypride PET Study
Ausgabe der Zeitschrift
47

Data source: Crossref

Abstract
<h4>Purpose</h4>Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing.<h4>Methods</h4>To quantify D2/D3-receptor density, we studied seven patients with temporal lobe epilepsy (TLE) and nine age-matched controls with positron emission tomography (PET) by using the high-affinity dopamine D2/D3-receptor ligand [18F]Fallypride ([18F]FP) suitable for imaging extrastriatal binding. TLE was defined by interictal and ictal video-EEG, magnetic resonance imaging (MRI), and [18F]fluorodeoxyglucose ([18F]FDG)-PET and was due to hippocampal sclerosis (HS), based on histology in all patients. Primary analysis was based on regions of interest (ROIs) defined on individual MRIs. For each patient, binding potential (BP) was calculated by using the simplified reference tissue model, and the epileptogenic was compared with the unaffected hemisphere in each ROI. To confirm the results, an additional voxel-based group analysis was performed by using statistical parametric mapping.<h4>Results</h4>Compared with controls, [18F]FP BP was significantly decreased in the epileptogenic temporal lobe in all patients. On ROI analysis, this reduction was evident in areas surrounding the seizure-onset zone at the pole (-34.2%) and lateral aspects (-32.9%) of the temporal lobe. Although the hippocampus [18F]FDG uptake (-8.1%) and hippocampal MR volume (-35.1%) were significantly reduced, no significant decrease of [18F]FP BP was found. Reduction of [18F]FP BP did not correlate with hippocampal atrophy.<h4>Conclusions</h4>D2/D3-receptor binding is reduced at the pole and in lateral aspects of the epileptogenic temporal lobe in patients with mesial TLE and HS. This area might correspond to "the irritative zone," indicating that D2/D3 receptors might play a specific role in the pathophysiology of mesial TLE.
Addresses
  • Department of Neurology, Johannes Gutenberg University, Rhineland-Palatinate, Germany. werhahn@uni-mainz.de
Autoren
  • Konrad J Werhahn
  • Christian Landvogt
  • Sven Klimpe
  • Hans-Georg Buchholz
  • Igor Yakushev
  • Thomas Siessmeier
  • Wibke Müller-Forell
  • Markus Piel
  • Frank Rösch
  • Martin Glaser
  • Mathias Schreckenberger
  • Peter Bartenstein
DOI
10.1111/j.1528-1167.2006.00561.x
eISSN
1528-1167
Externe Identifier
  • PubMed Identifier: 16922886
Open access
false
ISSN
0013-9580
Ausgabe der Veröffentlichung
8
Zeitschrift
Epilepsia
Schlüsselwörter
  • Hippocampus
  • Temporal Lobe
  • Humans
  • Epilepsy, Temporal Lobe
  • Sclerosis
  • Fluorine Radioisotopes
  • Benzamides
  • Pyrrolidines
  • Fluorodeoxyglucose F18
  • Receptors, Dopamine D2
  • Positron-Emission Tomography
  • Magnetic Resonance Imaging
  • Electroencephalography
  • Brain Mapping
  • Tissue Distribution
  • Videotape Recording
  • Adult
  • Male
  • Receptors, Dopamine D3
  • Functional Laterality
Sprache
eng
Medium
Print
Paginierung
1392 - 1396
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2006
Titel
Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
47

Data source: Europe PubMed Central

Abstract
PURPOSE: Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing. METHODS: To quantify D2/D3-receptor density, we studied seven patients with temporal lobe epilepsy (TLE) and nine age-matched controls with positron emission tomography (PET) by using the high-affinity dopamine D2/D3-receptor ligand [18F]Fallypride ([18F]FP) suitable for imaging extrastriatal binding. TLE was defined by interictal and ictal video-EEG, magnetic resonance imaging (MRI), and [18F]fluorodeoxyglucose ([18F]FDG)-PET and was due to hippocampal sclerosis (HS), based on histology in all patients. Primary analysis was based on regions of interest (ROIs) defined on individual MRIs. For each patient, binding potential (BP) was calculated by using the simplified reference tissue model, and the epileptogenic was compared with the unaffected hemisphere in each ROI. To confirm the results, an additional voxel-based group analysis was performed by using statistical parametric mapping. RESULTS: Compared with controls, [18F]FP BP was significantly decreased in the epileptogenic temporal lobe in all patients. On ROI analysis, this reduction was evident in areas surrounding the seizure-onset zone at the pole (-34.2%) and lateral aspects (-32.9%) of the temporal lobe. Although the hippocampus [18F]FDG uptake (-8.1%) and hippocampal MR volume (-35.1%) were significantly reduced, no significant decrease of [18F]FP BP was found. Reduction of [18F]FP BP did not correlate with hippocampal atrophy. CONCLUSIONS: D2/D3-receptor binding is reduced at the pole and in lateral aspects of the epileptogenic temporal lobe in patients with mesial TLE and HS. This area might correspond to "the irritative zone," indicating that D2/D3 receptors might play a specific role in the pathophysiology of mesial TLE.
Autoren
  • Konrad J Werhahn
  • Christian Landvogt
  • Sven Klimpe
  • Hans-Georg Buchholz
  • Igor Yakushev
  • Thomas Siessmeier
  • Wibke Müller-Forell
  • Markus Piel
  • Frank Rösch
  • Martin Glaser
  • Mathias Schreckenberger
  • Peter Bartenstein
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16922886
DOI
10.1111/j.1528-1167.2006.00561.x
ISSN
0013-9580
Ausgabe der Veröffentlichung
8
Zeitschrift
Epilepsia
Schlüsselwörter
  • Adult
  • Benzamides
  • Brain Mapping
  • Electroencephalography
  • Epilepsy, Temporal Lobe
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Functional Laterality
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Positron-Emission Tomography
  • Pyrrolidines
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Sclerosis
  • Temporal Lobe
  • Tissue Distribution
  • Videotape Recording
Sprache
eng
Country
United States
Paginierung
1392 - 1396
PII
EPI561
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2006
Titel
Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
47

Data source: PubMed

Autoren
  • Konrad J Werhahn
  • Christian Landvogt
  • Sven Klimpe
  • Hans-Georg Buchholz
  • Igor Yakushev
  • Thomas Siessmeier
  • Wibke Müller-Forell
  • Markus Piel
  • Frank Rösch
  • Martin Glaser
  • others
Zeitschrift
Epilepsia
Artikelnummer
8
Paginierung
1392 - 1396
Datum der Veröffentlichung
2006
Herausgeber
Blackwell Publishing Inc Malden, USA
Datum der Datenerfassung
2021
Titel
Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: An [18F] fallypride PET study
Sub types
  • article
Ausgabe der Zeitschrift
47

Data source: Manual

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