High opiate receptor binding potential in the human lateral pain system
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- U Baumgärtner
- HG Buchholz
- A Bellosevich
- W Magerl
- T Siessmeier
- R Rolke
- S Höhnemann
- M Piel
- F Rösch
- HJ Wester
- GJN Henriksen
- P Stoeter
- P Bartenstein
- RD Treede
- M Schreckenberger
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000236894800002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.neuroimage.2005.10.033
- eISSN
- 1095-9572
- Externe Identifier
- Clarivate Analytics Document Solution ID: 033ZY
- PubMed Identifier: 16337817
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- NEUROIMAGE
- Schlüsselwörter
- opioid
- PET
- human
- imaging
- insula
- operculum
- Paginierung
- 692 - 699
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Titel
- High opiate receptor binding potential in the human lateral pain system
- Sub types
- Article
- Ausgabe der Zeitschrift
- 30
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Ulf Baumgärtner
- Hans-Georg Buchholz
- Alexander Bellosevich
- Walter Magerl
- Thomas Siessmeier
- Roman Rolke
- Sabine Höhnemann
- Markus Piel
- Frank Rösch
- Hans-Jürgen Wester
- Gjermund Henriksen
- Peter Stoeter
- Peter Bartenstein
- Rolf-Detlef Treede
- Mathias Schreckenberger
- DOI
- 10.1016/j.neuroimage.2005.10.033
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- NeuroImage
- Sprache
- en
- Paginierung
- 692 - 699
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.neuroimage.2005.10.033
- Datum der Datenerfassung
- 2019
- Titel
- High opiate receptor binding potential in the human lateral pain system
- Ausgabe der Zeitschrift
- 30
Data source: Crossref
- Abstract
- To determine how opiate receptor distribution is co-localized with the distribution of nociceptive areas in the human brain, eleven male healthy volunteers underwent one PET scan with the subtype-nonselective opioidergic radioligand [(18)F]fluoroethyl-diprenorphine under resting conditions. The binding potential (BP), a parameter for the regional cerebral opioid receptor availability, was computed using the occipital cortex as reference region. The following regions of interest (ROIs) were defined on individual MR images: thalamus, sensory motor strip (SI/MI area), frontal operculum, parietal operculum, anterior insular cortex, posterior insular cortex, anterior cingulate cortex (ACC; peri- and subgenual part of "classical ACC" only), midcingulate cortex (MCC, posterior part of "classical ACC"), putamen, caudate nucleus and the amygdala. BP for [(18)F]fluoroethyl-diprenorphine was lowest in the sensory motor strip (0.30). Highest BP was found in thalamus (1.36), basal ganglia (putamen 1.22, caudate 1.16) and amygdala (1.21). In the cingulate cortex, ACC (1.11) had higher BP than MCC (0.86). In the operculo-insular region, we found high BPs in all ROIs: anterior insula (1.16), posterior insula (1.05), frontal operculum (0.99) and parietal operculum (0.77). Factor analysis of interindividual variability of opiate receptor BP revealed four factors (95% explained variance): (1) operculo-insular areas, ACC, MCC and putamen, (2) amygdala and thalamus, (3) caudate and thalamus, (4) SI/MI and MCC. Nociceptive areas of the lateral pain system (frontoparietal operculum and insula) have opiate receptor BPs significantly higher than SI/MI, comparable to anterior and midcingulate areas of the medial pain system. These findings suggest that the cortical anti-nociceptive effects of opiates are not only mediated by ACC and MCC, but also by the operculo-insular cortex, if it can be assumed that opioid binding mediates anti-nociception in those structures.
- Addresses
- Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr. 21. D-55099 Mainz, Germany. baumgaer@uni-mainz.de
- Autoren
- Ulf Baumgärtner
- Hans-Georg Buchholz
- Alexander Bellosevich
- Walter Magerl
- Thomas Siessmeier
- Roman Rolke
- Roman Rolke
- Sabine Höhnemann
- Markus Piel
- Frank Rösch
- Hans-Jürgen Wester
- Gjermund Henriksen
- Peter Stoeter
- Peter Bartenstein
- Rolf-Detlef Treede
- Mathias Schreckenberger
- DOI
- 10.1016/j.neuroimage.2005.10.033
- eISSN
- 1095-9572
- Externe Identifier
- PubMed Identifier: 16337817
- Open access
- false
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- NeuroImage
- Schlüsselwörter
- Brain
- Nociceptors
- Humans
- Pain
- Diprenorphine
- Receptors, Opioid
- Positron-Emission Tomography
- Magnetic Resonance Imaging
- Adult
- Middle Aged
- Male
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2005
- Paginierung
- 692 - 699
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Datum der Datenerfassung
- 2005
- Titel
- High opiate receptor binding potential in the human lateral pain system.
- Sub types
- Comparative Study
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 30
Data source: Europe PubMed Central
- Abstract
- To determine how opiate receptor distribution is co-localized with the distribution of nociceptive areas in the human brain, eleven male healthy volunteers underwent one PET scan with the subtype-nonselective opioidergic radioligand [(18)F]fluoroethyl-diprenorphine under resting conditions. The binding potential (BP), a parameter for the regional cerebral opioid receptor availability, was computed using the occipital cortex as reference region. The following regions of interest (ROIs) were defined on individual MR images: thalamus, sensory motor strip (SI/MI area), frontal operculum, parietal operculum, anterior insular cortex, posterior insular cortex, anterior cingulate cortex (ACC; peri- and subgenual part of "classical ACC" only), midcingulate cortex (MCC, posterior part of "classical ACC"), putamen, caudate nucleus and the amygdala. BP for [(18)F]fluoroethyl-diprenorphine was lowest in the sensory motor strip (0.30). Highest BP was found in thalamus (1.36), basal ganglia (putamen 1.22, caudate 1.16) and amygdala (1.21). In the cingulate cortex, ACC (1.11) had higher BP than MCC (0.86). In the operculo-insular region, we found high BPs in all ROIs: anterior insula (1.16), posterior insula (1.05), frontal operculum (0.99) and parietal operculum (0.77). Factor analysis of interindividual variability of opiate receptor BP revealed four factors (95% explained variance): (1) operculo-insular areas, ACC, MCC and putamen, (2) amygdala and thalamus, (3) caudate and thalamus, (4) SI/MI and MCC. Nociceptive areas of the lateral pain system (frontoparietal operculum and insula) have opiate receptor BPs significantly higher than SI/MI, comparable to anterior and midcingulate areas of the medial pain system. These findings suggest that the cortical anti-nociceptive effects of opiates are not only mediated by ACC and MCC, but also by the operculo-insular cortex, if it can be assumed that opioid binding mediates anti-nociception in those structures.
- Date of acceptance
- 2005
- Autoren
- Ulf Baumgärtner
- Hans-Georg Buchholz
- Alexander Bellosevich
- Walter Magerl
- Thomas Siessmeier
- Roman Rolke
- Sabine Höhnemann
- Markus Piel
- Frank Rösch
- Hans-Jürgen Wester
- Gjermund Henriksen
- Peter Stoeter
- Peter Bartenstein
- Rolf-Detlef Treede
- Mathias Schreckenberger
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/16337817
- DOI
- 10.1016/j.neuroimage.2005.10.033
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Neuroimage
- Schlüsselwörter
- Adult
- Brain
- Diprenorphine
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nociceptors
- Pain
- Positron-Emission Tomography
- Receptors, Opioid
- Sprache
- eng
- Country
- United States
- Paginierung
- 692 - 699
- PII
- S1053-8119(05)02408-0
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2006
- Titel
- High opiate receptor binding potential in the human lateral pain system.
- Sub types
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 30
Data source: PubMed
- Autoren
- Ulf Baumgärtner
- Hans-Georg Buchholz
- Alexander Bellosevich
- Walter Magerl
- Thomas Siessmeier
- Roman Rolke
- Sabine Höhnemann
- Markus Piel
- Frank Rösch
- Hans-Jürgen Wester
- others
- Zeitschrift
- Neuroimage
- Artikelnummer
- 3
- Paginierung
- 692 - 699
- Datum der Veröffentlichung
- 2006
- Herausgeber
- Elsevier
- Datum der Datenerfassung
- 2021
- Titel
- High opiate receptor binding potential in the human lateral pain system
- Sub types
- article
- Ausgabe der Zeitschrift
- 30
Data source: Manual
- Beziehungen:
- Property of