Efficient synthesis of 2-bromo-1-[18F]fluoroethane and its application in the automated preparation of 18F-fluoroethylated compounds
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- S Comagic
- M Piel
- R Schirrmacher
- S Höhnemann
- F Rösch
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000175985400012&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: 558UP
- PubMed Identifier: 12102341
- ISSN
- 0969-8043
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- APPLIED RADIATION AND ISOTOPES
- Schlüsselwörter
- 2-bromo-1-[F-18]fluoroethane
- fluoroethylation
- Artikelnummer
- PII S0969-8043(01)00237-8
- Paginierung
- 847 - 851
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Titel
- Efficient synthesis of 2-bromo-1-[<SUP>18</SUP>F]fluoroethane and its application in the automated preparation of <SUP>18</SUP>F-fluoroethylated compounds
- Sub types
- Article
- Ausgabe der Zeitschrift
- 56
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- S Comagic
- M Piel
- R Schirrmacher
- S Höhnemann
- F Rösch
- DOI
- 10.1016/s0969-8043(01)00237-8
- ISSN
- 0969-8043
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Applied Radiation and Isotopes
- Sprache
- en
- Paginierung
- 847 - 851
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/s0969-8043(01)00237-8
- Datum der Datenerfassung
- 2019
- Titel
- Efficient synthesis of 2-bromo-1-[18F]fluoroethane and its application in the automated preparation of 18F-fluoroethylated compounds
- Ausgabe der Zeitschrift
- 56
Data source: Crossref
- Abstract
- An efficient synthesis of 2-bromo-1-[18F]fluoroethane from commercially available 1,2-dibromoethane and its integration into an automated preparation device was developed for the routine synthesis of 18F-fluoroethylated compounds. The 1,2-dibromoethane was reacted with the [18F]fluoride/Kryptofix 2.2.2./carbonate complex in acetonitrile at 70 degrees C for 3 min resulting in 60-70% radiochemical yields. The crude reaction mixture was diluted with water, loaded on a LiChrolute EN-cartridge, eluted with acetonitrile and passed through an AluminaB-cartridge. This method provides 2-bromo-1-[18F]fluoroethane with 98% radiochemical purity and <0.1 micromol of 1,2-dibromoethane within 10 min, thus avoiding a purifying distillation step. This method was easily integrated into an automated system for the routine synthesis of 18F-fluoroethylated compounds.
- Addresses
- Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Germany.
- Autoren
- S Comagic
- M Piel
- R Schirrmacher
- S Höhnemann
- F Rösch
- DOI
- 10.1016/s0969-8043(01)00237-8
- eISSN
- 1872-9800
- Externe Identifier
- PubMed Identifier: 12102341
- Open access
- false
- ISSN
- 0969-8043
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Sprache
- eng
- Medium
- Paginierung
- 847 - 851
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Datum der Datenerfassung
- 2002
- Titel
- Efficient synthesis of 2-bromo-1-[18F]fluoroethane and its application in the automated preparation of 18F-fluoroethylated compounds.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 56
Data source: Europe PubMed Central
- Abstract
- An efficient synthesis of 2-bromo-1-[18F]fluoroethane from commercially available 1,2-dibromoethane and its integration into an automated preparation device was developed for the routine synthesis of 18F-fluoroethylated compounds. The 1,2-dibromoethane was reacted with the [18F]fluoride/Kryptofix 2.2.2./carbonate complex in acetonitrile at 70 degrees C for 3 min resulting in 60-70% radiochemical yields. The crude reaction mixture was diluted with water, loaded on a LiChrolute EN-cartridge, eluted with acetonitrile and passed through an AluminaB-cartridge. This method provides 2-bromo-1-[18F]fluoroethane with 98% radiochemical purity and <0.1 micromol of 1,2-dibromoethane within 10 min, thus avoiding a purifying distillation step. This method was easily integrated into an automated system for the routine synthesis of 18F-fluoroethylated compounds.
- Autoren
- S Comagic
- M Piel
- R Schirrmacher
- S Höhnemann
- F Rösch
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/12102341
- DOI
- 10.1016/s0969-8043(01)00237-8
- ISSN
- 0969-8043
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Appl Radiat Isot
- Sprache
- eng
- Country
- England
- Paginierung
- 847 - 851
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2002
- Titel
- Efficient synthesis of 2-bromo-1-[18F]fluoroethane and its application in the automated preparation of 18F-fluoroethylated compounds.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 56
Data source: PubMed
- Beziehungen:
- Property of