Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits of mice AD-models showing plaques, and also recently in early stage AD mutants prior to amyloid deposition. However, early functional effects of AD on cortical microcircuits remain unresolved. Using two-photon calcium imaging, we found altered temporal distributions (burstiness) in the spontaneous activity of layer II/III visual cortex neurons, in a mouse model of familial Alzheimer’s disease (5xFAD), before plaque formation. Graph theory (GT) measures revealed a distinct network topology of 5xFAD microcircuits, as compared to healthy controls, suggesting degradation of parameters related to network robustness. After treatment with acitretin, we observed a re-balancing of those network measures in 5xFAD mice; particularly in the mean degree distribution, related to network development and resilience, and post-treatment values resembled those of age-matched controls. Further, behavioral deficits, and the increase of excitatory synapse numbers in layer II/III were reversed after treatment. GT is widely applied for whole-brain network analysis in human neuroimaging, we here demonstrate the translational value of GT as a multi-level tool, to probe networks at different levels in order to assess treatments, explore mechanisms, and contribute to early diagnosis.</jats:p>
- Autoren
- Eduardo Rosales Jubal
- Miriam Schwalm
- Malena dos Santos Guilherme
- Florian Schuck
- Sven Reinhardt
- Amanda Tose
- Zeke Barger
- Mona K Roesler
- Nicolas Ruffini
- Anna Wierczeiko
- Michael J Schmeisser
- Ulrich Schmitt
- Kristina Endres
- Albrecht Stroh
- DOI
- 10.1038/s41598-021-85912-0
- eISSN
- 2045-2322
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Scientific Reports
- Sprache
- en
- Artikelnummer
- 6649
- Online publication date
- 2021
- Status
- Published online
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/s41598-021-85912-0
- Datum der Datenerfassung
- 2022
- Titel
- Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease
- Ausgabe der Zeitschrift
- 11
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Eduardo Rosales Jubal
- Miriam Schwalm
- Malena dos Santos Guilherme
- Florian Schuck
- Sven Reinhardt
- Amanda Tose
- Zeke Barger
- Mona K Roesler
- Nicolas Ruffini
- Anna Wierczeiko
- Michael J Schmeisser
- Ulrich Schmitt
- Kristina Endres
- Albrecht Stroh
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1038/s41598-021-85912-0
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2045-2322
- Zeitschrift
- Scientific reports
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 6649
- Datum der Veröffentlichung
- 2021
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/6364
- Herausgeber
- Macmillan Publishers Limited, part of Springer Nature
- Herausgeber URL
- https://doi.org/10.1038/s41598-021-85912-0
- Datum der Datenerfassung
- 2021
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Zugang
- Public
- Titel
- Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease
- Ausgabe der Zeitschrift
- 11
Files
jubal_eduardo_rosales-acitretin_reve-20210917115402096.pdf
Data source: OPENSCIENCE.UB