Zinc Oxide Nanoparticles Can Intervene in Radiation-Induced Senescence and Eradicate Residual Tumor Cells
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:p>Despite recent advancements in tumor therapy, metastasis and tumor relapse remain major complications hindering the complete recovery of many cancer patients. Dormant tumor cells, which reside in the body, possess the ability to re-enter the cell cycle after therapy. This phenomenon has been attributed to therapy-induced senescence. We show that these cells could be targeted by the use of zinc oxide nanoparticles (ZnO NPs). In the present study, the properties of tumor cells after survival of 16 Gy gamma-irradiation were investigated in detail. Analysis of morphological features, proliferation, cell cycle distribution, and protein expression revealed classical hallmarks of senescent cells among the remnant cell mass after irradiation. The observed radiation-induced senescence was associated with the increased ability to withstand further irradiation. Additionally, tumor cells were able to re-enter the cell cycle and proliferate again after weeks. Treatment with ZnO NPs was evaluated as a therapeutical approach to target senescent cells. ZnO NPs were suitable to induce cell death in senescent, irradiation-resistant tumor cells. Our findings underline the pathophysiological relevance of remnant tumor cells that survived first-line radiotherapy. Additionally, we highlight the therapeutic potential of ZnO NPs for targeting senescent tumor cells.</jats:p>
- Autoren
- Nadine Wiesmann
- Rita Gieringer
- Melanie Viel
- Jonas Eckrich
- Wolfgang Tremel
- Juergen Brieger
- DOI
- 10.3390/cancers13122989
- eISSN
- 2072-6694
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Cancers
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 2989 - 2989
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/cancers13122989
- Datum der Datenerfassung
- 2021
- Titel
- Zinc Oxide Nanoparticles Can Intervene in Radiation-Induced Senescence and Eradicate Residual Tumor Cells
- Ausgabe der Zeitschrift
- 13
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Nadine Wiesmann
- Rita Gieringer
- Melanie Viel
- Jonas Eckrich
- Wolfgang Tremel
- Juergen Brieger
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.3390/cancers13122989
- Funding acknowledgements
- Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2072-6694
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Cancers
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 2989
- Datum der Veröffentlichung
- 2021
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/6333
- Herausgeber
- MDPI
- Herausgeber URL
- https://doi.org/10.3390/cancers13122989
- Datum der Datenerfassung
- 2021
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Zugang
- Public
- Titel
- Zinc oxide nanoparticles can intervene in radiation-induced senescence and eradicate residual tumor cells
- Ausgabe der Zeitschrift
- 13
Files
wiesmann_nadine-zinc_oxide_nan-20210901160012551.pdf
Data source: OPENSCIENCE.UB