Targeting of Immune Cells with Trimannosylated Liposomes

Publication type:
Journal article
Metadata:
Autoren
  • Karolin Wagener
  • Matthias Bros
  • Matthias Krumb
  • Jens Langhanki
  • Stefanie Pektor
  • Matthias Worm
  • Meike Schinnerer
  • Evelyn Montermann
  • Matthias Miederer
  • Holger Frey
  • Till Opatz
  • Frank Roesch
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000517957200001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/adtp.201900185
eISSN
2366-3987
Externe Identifier
  • Clarivate Analytics Document Solution ID: LY5SU
Ausgabe der Veröffentlichung
6
Zeitschrift
ADVANCED THERAPEUTICS
Schlüsselwörter
  • DC-SIGN
  • dendritic cells
  • liposomes
  • targeting
  • trimannose
Artikelnummer
UNSP 1900185
Datum der Veröffentlichung
2020
Status
Published
Titel
Targeting of Immune Cells with Trimannosylated Liposomes
Sub types
  • Article
Ausgabe der Zeitschrift
3

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>Dendritic cells (DCs) are a compelling target in cancer immunotherapy as they initialize strong antigen‐specific immune responses. Drug delivery systems (DDSs) such as liposomes provide the opportunity to deliver antigens and immunostimulatory molecules to DCs, which in turn initiate an antigen‐specific immune response. To address predominantly DCs, DDSs need to be equipped with targeting moieties. This study evaluates liposomes, bearing the oligosaccharide trimannose on their surface, for their ability to address DCs in vitro and in vivo. Trimannose as a saccharidic structure is known to be recognized by receptors on the surface of DCs. To obtain trimannosylated liposomes, azide‐bearing trimannose is coupled to alkyne‐functionalized hyperbranched polyglycerol (<jats:italic>hb</jats:italic>PG) with a bis(hexadecyl)glycerol (BisHD) anchor in a Cu(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC). To enable tracking of the liposomes in vivo, the trimannosylated BisHD‐<jats:italic>hb</jats:italic>PG lipids are radiolabeled with <jats:sup>18</jats:sup>F in a CuAAC. Subsequently, liposomes are produced via the thin‐film hydration method followed by extrusion. The behavior of the trimannosylated liposomes is evaluated in in vitro cell binding assays and in vivo µPET and ex vivo biodistribution studies in healthy C57BL/6 mice and the results are compared to similar liposomes not bearing trimannose on their surface.</jats:p>
Autoren
  • Karolin Wagener
  • Matthias Bros
  • Matthias Krumb
  • Jens Langhanki
  • Stefanie Pektor
  • Matthias Worm
  • Meike Schinnerer
  • Evelyn Montermann
  • Matthias Miederer
  • Holger Frey
  • Till Opatz
  • Frank Rösch
DOI
10.1002/adtp.201900185
eISSN
2366-3987
ISSN
2366-3987
Ausgabe der Veröffentlichung
6
Zeitschrift
Advanced Therapeutics
Sprache
en
Online publication date
2020
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/adtp.201900185
Datum der Datenerfassung
2023
Titel
Targeting of Immune Cells with Trimannosylated Liposomes
Ausgabe der Zeitschrift
3

Data source: Crossref

Author's licence
CC-BY-NC-ND
Autoren
  • Karolin Wagener
  • Matthias Bros
  • Matthias Krumb
  • Jens Langhanki
  • Stefanie Pektor
  • Matthias Worm
  • Meike Schinnerer
  • Evelyn Montermann
  • Matthias Miederer
  • Holger Frey
  • Till Opatz
  • Frank Rösch
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1002/adtp.201900185
File(s) embargoed
false
Open access
true
ISSN
2366-3987
Ausgabe der Veröffentlichung
6
Zeitschrift
Advanced therapeutics
Schlüsselwörter
  • 540 Chemie
  • 540 Chemistry and allied sciences
  • 570 Biowissenschaften
  • 570 Life sciences
Sprache
eng
Open access status
Open Access
Paginierung
1900185
Datum der Veröffentlichung
2020
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/6282
Herausgeber
Wiley-VCH
Herausgeber URL
https://doi.org/10.1002/adtp.201900185
Datum der Datenerfassung
2021
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Zugang
Public
Titel
Targeting of immune cells with trimannosylated liposomes
Ausgabe der Zeitschrift
3

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wagener_karolin-targeting_of_i-20210812113737053.pdf

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