Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura

Publication type:
Journal article
Metadata:
Abstract
<jats:p>Autoimmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalised microvascular thrombosis. Survivors have a high prevalence of depression and impaired cognitive function. The aim of this study was to determine whether life circumstances and personality have an influence on the development and severity of depression and anxiety in iTTP patients and how they impact the quality of life. With validated questionnaires, we examined the prevalence of depression and anxiety symptoms in 104 iTTP patients, as well as parameters of subjective cognitive deficits, quality of life, attitude to life and resilience. iTTP patients had significantly more depressive symptoms (p &lt; 0.001), a tendency to have anxiety disorders (p = 0.035) and a significantly worse cognitive performance (p = 0.008) compared to the controls. Sex, age, physical activity and partnership status had no significant influence on depression, whereas the number of comorbidities did. Lower scores of resilience, attitude to life and quality of life were reported by patients compared to controls. iTTP patients had a high prevalence of depression and anxiety, as well as a more negative attitude to life and low resilience. Resilience correlated negatively with the severity of the depression. Furthermore, quality of life and cognitive performance were significantly reduced.</jats:p>
Autoren
  • Tanja Falter
  • Sibylle Böschen
  • Markus Schepers
  • Manfred Beutel
  • Karl Lackner
  • Inge Scharrer
  • Bernhard Lämmle
DOI
10.3390/jcm10020365
eISSN
2077-0383
Ausgabe der Veröffentlichung
2
Zeitschrift
Journal of Clinical Medicine
Sprache
en
Online publication date
2021
Paginierung
365 - 365
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/jcm10020365
Datum der Datenerfassung
2021
Titel
Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura
Ausgabe der Zeitschrift
10

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Tanja Falter
  • Sibylle Böschen
  • Markus Schepers
  • Manfred Beutel
  • Karl Lackner
  • Inge Scharrer
  • Bernhard Lämmle
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.3390/jcm10020365
Funding acknowledgements
  • Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz
File(s) embargoed
false
Open access
true
ISSN
2077-0383
Ausgabe der Veröffentlichung
2
Zeitschrift
Journal of Clinical Medicine
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
365
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/6195
Herausgeber
MDPI
Herausgeber URL
https://doi.org/10.3390/jcm10020365
Datum der Datenerfassung
2021
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Zugang
Public
Titel
Influence of personality, resilience and life conditions on depression and anxiety in 104 patients having survived acute autoimmune thrombotic thrombocytopenic purpura
Ausgabe der Zeitschrift
10

Files

falter_tanja-influence_of_p-20210706182255274.pdf

Data source: OPENSCIENCE.UB

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