Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Tobias A Bauer
- Natalie K Horvat
- Oriana Marques
- Sara Chocarro
- Christina Mertens
- Silvia Colucci
- Sascha Schmitt
- Luca M Carrella
- Svenja Morsbach
- Kaloian Koynov
- Federico Fenaroli
- Peter Bluemler
- Michaela Jung
- Rocio Sotillo
- Matthias W Hentze
- Martina U Muckenthaler
- Matthias Barz
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000662125700001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/adhm.202100385
- eISSN
- 2192-2659
- Externe Identifier
- Clarivate Analytics Document Solution ID: WC5UW
- PubMed Identifier: 34137217
- ISSN
- 2192-2640
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- ADVANCED HEALTHCARE MATERIALS
- Schlüsselwörter
- cross-linking
- iron metabolism
- macrophage polarization
- polymeric micelle
- polypept(o)ide
- superparamagnetic iron oxide nanoparticles
- Artikelnummer
- ARTN 2100385
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Iron is an essential co‐factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine<jats:italic>‐block‐</jats:italic>poly(<jats:italic>S</jats:italic>‐ethylsulfonyl‐<jats:sc>l</jats:sc>‐cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(<jats:italic>S</jats:italic>‐ethylsulfonyl‐<jats:sc>l</jats:sc>‐cysteine) block, yielding glutathione‐responsive core cross‐linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild‐type C57Bl/6N mice. Most importantly, the controlled release concept to deliver iron oxide in redox‐responsive CCPMs induces significantly stronger macrophage activation than any other iron source at identical iron levels (e.g., Feraheme), directing to a new class of immune therapeutics.</jats:p>
- Autoren
- Tobias A Bauer
- Natalie K Horvat
- Oriana Marques
- Sara Chocarro
- Christina Mertens
- Silvia Colucci
- Sascha Schmitt
- Luca M Carrella
- Svenja Morsbach
- Kaloian Koynov
- Federico Fenaroli
- Peter Blümler
- Michaela Jung
- Rocio Sotillo
- Matthias W Hentze
- Martina U Muckenthaler
- Matthias Barz
- DOI
- 10.1002/adhm.202100385
- eISSN
- 2192-2659
- ISSN
- 2192-2640
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- Advanced Healthcare Materials
- Sprache
- en
- Online publication date
- 2021
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/adhm.202100385
- Datum der Datenerfassung
- 2023
- Titel
- Core Cross‐Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages
- Ausgabe der Zeitschrift
- 10
Data source: Crossref
- Abstract
- Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(S-ethylsulfonyl-l-cysteine) block, yielding glutathione-responsive core cross-linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild-type C57Bl/6N mice. Most importantly, the controlled release concept to deliver iron oxide in redox-responsive CCPMs induces significantly stronger macrophage activation than any other iron source at identical iron levels (e.g., Feraheme), directing to a new class of immune therapeutics.
- Addresses
- Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.
- Autoren
- Tobias A Bauer
- Natalie K Horvat
- Oriana Marques
- Sara Chocarro
- Christina Mertens
- Silvia Colucci
- Sascha Schmitt
- Luca M Carrella
- Svenja Morsbach
- Kaloian Koynov
- Federico Fenaroli
- Peter Blümler
- Michaela Jung
- Rocio Sotillo
- Matthias W Hentze
- Martina U Muckenthaler
- Matthias Barz
- DOI
- 10.1002/adhm.202100385
- eISSN
- 2192-2659
- Externe Identifier
- PubMed Identifier: 34137217
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: SFB1036
- Deutsche Forschungsgemeinschaft: SFB1066
- Deutsche Forschungsgemeinschaft: SFB1118
- Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg: DZL TLRC‐H
- Bundesministerium für Bildung und Forschung: Nr 031L0191C
- Max-Planck-Gesellschaft:
- Open access
- false
- ISSN
- 2192-2640
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- Advanced healthcare materials
- Schlüsselwörter
- Macrophages
- Animals
- Mice
- Inflammation
- Iron
- Polymers
- Micelles
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2021
- Paginierung
- e2100385
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY-NC
- Datum der Datenerfassung
- 2021
- Titel
- Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 10
Data source: Europe PubMed Central
- Abstract
- Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(S-ethylsulfonyl-l-cysteine) block, yielding glutathione-responsive core cross-linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild-type C57Bl/6N mice. Most importantly, the controlled release concept to deliver iron oxide in redox-responsive CCPMs induces significantly stronger macrophage activation than any other iron source at identical iron levels (e.g., Feraheme), directing to a new class of immune therapeutics.
- Autoren
- Tobias A Bauer
- Natalie K Horvat
- Oriana Marques
- Sara Chocarro
- Christina Mertens
- Silvia Colucci
- Sascha Schmitt
- Luca M Carrella
- Svenja Morsbach
- Kaloian Koynov
- Federico Fenaroli
- Peter Blümler
- Michaela Jung
- Rocio Sotillo
- Matthias W Hentze
- Martina U Muckenthaler
- Matthias Barz
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/34137217
- DOI
- 10.1002/adhm.202100385
- eISSN
- 2192-2659
- Ausgabe der Veröffentlichung
- 19
- Zeitschrift
- Adv Healthc Mater
- Schlüsselwörter
- cross-linking
- iron metabolism
- macrophage polarization
- polymeric micelle
- polypept(o)ide
- superparamagnetic iron oxide nanoparticles
- Animals
- Inflammation
- Iron
- Macrophages
- Mice
- Micelles
- Polymers
- Sprache
- eng
- Country
- Germany
- Paginierung
- e2100385
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 10
Data source: PubMed
- Beziehungen:
- Property of