Socioeconomic differences in the risk of childhood central nervous system tumors in Denmark: a nationwide register-based case–control study
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Differences in the risk of childhood central nervous system (CNS) tumors by socioeconomic status (SES) may enhance etiologic insights. We conducted a nationwide register-based case–control study to evaluate socioeconomic differences in the risk of childhood CNS tumors in Denmark and examined whether associations varied by different SES measures, time points of assessment, specific tumor types, and age at diagnosis.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We identified all children born between 1981 and 2013 and diagnosed with a CNS tumor at ages 0–19 years (<jats:italic>n</jats:italic> = 1,273) from the Danish Cancer Registry and sampled four individually matched controls per case (<jats:italic>n</jats:italic> = 5,086). We used conditional logistic regression models to estimate associations with individual-level and neighborhood-level socioeconomic measures.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We observed elevated risks of ependymoma and embryonal CNS tumors in association with higher parental education (odds ratios (ORs) of 1.6–2.1 for maternal or paternal high education and ependymoma) and higher risk of all tumor types in association with higher maternal income, e.g., OR 1.93; 95% CI 1.05–3.52 for high versus low income for astrocytoma and other gliomas. Associations were often stronger in children diagnosed at ages 5–19 years. We found little evidence for an association with neighborhood SES.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This large nationwide register study with minimal risk of bias showed that having parents with higher educational level and a mother with higher income was associated with a higher risk of childhood CNS tumors. Bias or under-ascertainment of cases among families with low income or basic education is unlikely to explain our findings.</jats:p> </jats:sec>
- Autoren
- Friederike Erdmann
- Ulla Arthur Hvidtfeldt
- Mette Sørensen
- Ole Raaschou-Nielsen
- DOI
- 10.1007/s10552-020-01332-x
- eISSN
- 1573-7225
- ISSN
- 0957-5243
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Cancer Causes & Control
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 915 - 929
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s10552-020-01332-x
- Datum der Datenerfassung
- 2021
- Titel
- Socioeconomic differences in the risk of childhood central nervous system tumors in Denmark: a nationwide register-based case–control study
- Ausgabe der Zeitschrift
- 31
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Friederike Erdmann
- Hvidtfeldt Ulla Arthur
- Mette Sørensen
- Ole Raaschou-Nielsen
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1007/s10552-020-01332-x
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1573-7225
- Zeitschrift
- Cancer causes & control
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 915 - 929
- Datum der Veröffentlichung
- 2020
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/6080
- Herausgeber
- Springer Science + Business Media B.V.
- Herausgeber URL
- https://doi.org/10.1007/s10552-020-01332-x
- Datum der Datenerfassung
- 2021
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Zugang
- Public
- Titel
- Socioeconomic differences in the risk of childhood central nervous system tumors in Denmark : a nationwide register-based case-control study
- Ausgabe der Zeitschrift
- 31
Files
erdmann_friederika-socioeconomic_-20210614121915632.pdf
Data source: OPENSCIENCE.UB