Genetic findings in miscarriages and their relation to the number of previous miscarriages

Publication type:
Journal article
Metadata:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Early pregnancy loss leads to a devastating situation for many couples. Genetic disorders found in the pregnancy tissue are a frequent cause of miscarriages. It is unclear whether maternal age or previous miscarriages are associated with a higher chromosomal anomaly rate. This study aimed to determine the cytogenetical distribution of chromosomal disorders in couples after one or more previous miscarriages as well as the influence of maternal age.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>406 fetal tissue samples obtained after spontaneous abortion between 2010 and 2014 were successfully karyotyped. This included 132 couples with at least two losses and 274 couples with sporadic miscarriage. Normal and abnormal karyotype rate was determined for age, parity, gravidity, gestational week and number of previous miscarriages by logistic regression analysis.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>145 (35.71%) fetal tissue samples had a normal karyotype, and 261 (64.8%) did not.</jats:p> <jats:p>After adjusting for age, older patients have a statistically significantly higher probability of genetic disorders in the pregnancy tissue (<jats:italic>p</jats:italic> &lt; 0.001, OR 1.064, 95% CI 1.03–1.11). With each additional year, the probability of finding chromosomal abnormalities in a miscarriage increased by 6.4%. Patients younger than 35 years have a lower probability of having chromosomal disorders in the aborted material after two or more miscarriages than after sporadic miscarriages (50.7 vs. 58.9%) (<jats:italic>p</jats:italic> = 0.014, OR 0.67, 95% CI 0.48–0.914). Nevertheless, the risk of embryonic chromosomal disorders in patients aged 35 and above increased from 75.5% in sporadic miscarriages to 82.4% after more than one pregnancy losses (<jats:italic>p</jats:italic> = 0.59, OR 1.14, 95% CI  − 0.72 to 1.92).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Chromosomal disorders found after one or more previous miscarriages are related to patients’ age. Couples suffering two or more miscarriages should be further researched, especially in younger patients.</jats:p> </jats:sec>
Autoren
  • R Gomez
  • N Hafezi
  • M Amrani
  • S Schweiger
  • MK Dewenter
  • P Thomas
  • C Lieb
  • A Hasenburg
  • C Skala
DOI
10.1007/s00404-020-05859-x
eISSN
1432-0711
ISSN
0932-0067
Ausgabe der Veröffentlichung
6
Zeitschrift
Archives of Gynecology and Obstetrics
Sprache
en
Online publication date
2020
Paginierung
1425 - 1432
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00404-020-05859-x
Datum der Datenerfassung
2021
Titel
Genetic findings in miscarriages and their relation to the number of previous miscarriages
Ausgabe der Zeitschrift
303

Data source: Crossref

Other metadata sources:
Author's licence
CC-BY
Autoren
  • Ruth Gomez
  • N Hafezi
  • M Amrani
  • Susann Schweiger
  • Malin K Dewenter
  • Petra Thomas
  • C Lieb
  • Annette Hasenburg
  • Christine Skala
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1007/s00404-020-05859-x
File(s) embargoed
false
Open access
true
ISSN
1432-0711
Zeitschrift
Archives of gynecology and obstetrics
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
1425 - 1432
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/5815
Herausgeber
Springer
Herausgeber URL
https://doi.org/10.1007/s00404-020-05859-x
Datum der Datenerfassung
2021
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Zugang
Public
Titel
Genetic findings in miscarriages and their relation to the number of previous miscarriages
Ausgabe der Zeitschrift
303

Files

gomez_ruth-genetic_findin-20210510104801235.pdf

Data source: OPENSCIENCE.UB

Tools