Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental condition primarily characterized by an impairment of social interaction combined with the occurrence of repetitive behaviors. ASD starts in childhood and prevails across the lifespan. The variability of its clinical presentation renders early diagnosis difficult. Mutations in synaptic genes and alterations of mitochondrial functions are considered important underlying pathogenic factors, but it is obvious that we are far from a comprehensive understanding of ASD pathophysiology. At the synapse, mitochondria perform diverse functions, which are clearly not limited to their classical role as energy providers. Here, we review the current knowledge about mitochondria at the synapse and summarize the mitochondrial disturbances found in mouse models of ASD and other ASD-related neurodevelopmental disorders, like DiGeorge syndrome, Rett syndrome, Tuberous sclerosis complex, and Down syndrome.</jats:p>
- Autoren
- Liliana Rojas-Charry
- Leonardo Nardi
- Axel Methner
- Michael J Schmeisser
- DOI
- 10.1007/s00109-020-02018-2
- eISSN
- 1432-1440
- ISSN
- 0946-2716
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Journal of Molecular Medicine
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 161 - 178
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s00109-020-02018-2
- Datum der Datenerfassung
- 2021
- Titel
- Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders
- Ausgabe der Zeitschrift
- 99
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Liliana Rojas-Charry
- Leonardo Nardi
- Axel Methner
- Michael J Schmeisser
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1007/s00109-020-02018-2
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1432-1440
- Zeitschrift
- Journal of molecular medicine
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 161 - 178
- Datum der Veröffentlichung
- 2021
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/5837
- Herausgeber
- Springer
- Herausgeber URL
- https://doi.org/10.1007/s00109-020-02018-2
- Datum der Datenerfassung
- 2021
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Zugang
- Public
- Titel
- Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders
- Ausgabe der Zeitschrift
- 99
Files
rojas-charry_liliana-abnormalities_-20210423151435856.pdf
Data source: OPENSCIENCE.UB