QFR Predicts the Incidence of Long-Term Adverse Events in Patients with Suspected CAD: Feasibility and Reproducibility of the Method
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:p>AIMS: We evaluate feasibility and reproducibility of post hoc quantitative flow ratio (QFR) measurements and their prognostic predictive power during long-term follow-up. METHODS AND RESULTS: Between 2010 and 2012, 167 patients without angiographic evidence of significant stenoses were enrolled in a prospective registry. Of these patients, 96% presented 7 years follow-up data. QFR was measured post hoc by three certified investigators. QFR analysis was feasible in 71% of left anterior descending (LAD), 72% of left circumflex (LCX), and 61% of right (RCA) coronaries for a total of 350 measurements repeated in triplicate. Coefficients of variation were 2.1% for RCA and LCX, and 2.8% for the LAD (quartile coefficients of dispersion respectively 1.5, 1.4, and 1.3). QFR ≤0.80 was recorded in 25 patients (27 vessels, in 74% of the cases LAD). A total of 86 major adverse cardiovascular and cerebrovascular events were observed in 76 patients. QFR ≤0.80 in at least one of the three vessels was the strongest predictor of events (HR 3.14, 95%CI 1.78–5.54, p = 0.0001). This association was maintained in several sensitivity analyses. CONCLUSIONS: QFR reproducibility is acceptable, even when analysis is performed post hoc. A pathological QFR is not rare in patients without angiographic evidence of significant stenosis and is a predictor of incident events during long-term follow-up. Condensed Abstract: In a post hoc analysis of 167 patients without evidence of angiographic significant stenosis, the presence of QFR value ≤0.80 in at least one of the three coronary vessels showed to be the strongest predictor of major adverse cardiovascular and cerebrovascular events during long-term follow-up. QFR reproducibility have been shown to be acceptable among experienced operators.</jats:p>
- Autoren
- Andrea Buono
- Annika Mühlenhaus
- Tabitha Schäfer
- Ann-Kristin Trieb
- Julian Schmeißer
- Franziska Koppe
- Thomas Münzel
- Remzi Anadol
- Tommaso Gori
- DOI
- 10.3390/jcm9010220
- eISSN
- 2077-0383
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Journal of Clinical Medicine
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 220 - 220
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/jcm9010220
- Datum der Datenerfassung
- 2020
- Titel
- QFR Predicts the Incidence of Long-Term Adverse Events in Patients with Suspected CAD: Feasibility and Reproducibility of the Method
- Ausgabe der Zeitschrift
- 9
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY
- Autoren
- Andrea Buono
- Annika Mühlenhaus
- Tabitha Schäfer
- Ann-Kristin Trieb
- Julian Schmeißer
- Franziska Koppe
- Thomas Münzel
- Remzi Anadol
- Tommaso Gori
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- URN
- urn:nbn:de:hebis:77-publ-598682
- DOI
- 10.3390/jcm9010220
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2077-0383
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Journal of Clinical Medicine
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- Art. 220
- Datum der Veröffentlichung
- 2020
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/4937
- Herausgeber
- MDPI
- Herausgeber URL
- http://dx.doi.org/10.3390/jcm9010220
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- QFR predicts the incidence of long-term adverse events in patients with suspected CAD : feasibility and reproducibility of the method
- Ausgabe der Zeitschrift
- 9
Files
59868.pdf
Data source: OPENSCIENCE.UB