Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000467709100012&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1038/s41598-019-43796-1
Externe Identifier
  • Clarivate Analytics Document Solution ID: HX9EF
  • PubMed Identifier: 31086243
ISSN
2045-2322
Zeitschrift
SCIENTIFIC REPORTS
Artikelnummer
ARTN 7270
Datum der Veröffentlichung
2019
Status
Published
Titel
Long-lived <i>Temnothorax</i> ant queens switch from investment in immunity to antioxidant production with age
Sub types
  • Article
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>Senescence is manifested by an increase in molecular damage and a deterioration of biological functions with age. In most organisms, body maintenance is traded-off with reproduction. This negative relationship between longevity and fecundity is also evident on the molecular level. Exempt from this negative trait association, social insect queens are both extremely long-lived and highly fecund. Here, we study changes in gene expression with age and fecundity in ant queens to understand the molecular basis of their long lifespan. We analyse tissue-specific gene expression in young founding queens and old fecund queens of the ant <jats:italic>Temnothorax rugatulus</jats:italic>. More genes altered their expression with age in the fat body than in the brain. Despite strong differences in ovary development, few fecundity genes were differentially expressed. Young founding queens invested in immunity (<jats:italic>i</jats:italic>.<jats:italic>e</jats:italic>. activation of <jats:italic>Toll</jats:italic> signalling pathway) and resistance against environmental and physiological stress (<jats:italic>i</jats:italic>.<jats:italic>e</jats:italic>. down-regulation of TOR pathway). Conversely, established older queens invested into anti-aging mechanisms through an overproduction of antioxidants (<jats:italic>i</jats:italic>.<jats:italic>e</jats:italic>. <jats:italic>upregulation of catalase</jats:italic>, <jats:italic>superoxide dismutase</jats:italic>). Finally, we identified candidate genes and pathways, potentially involved in the association between fertility and longevity in social insects and its proximate basis.</jats:p>
Autoren
DOI
10.1038/s41598-019-43796-1
eISSN
2045-2322
Ausgabe der Veröffentlichung
1
Zeitschrift
Scientific Reports
Sprache
en
Artikelnummer
7270
Online publication date
2019
Status
Published online
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1038/s41598-019-43796-1
Datum der Datenerfassung
2022
Titel
Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
Senescence is manifested by an increase in molecular damage and a deterioration of biological functions with age. In most organisms, body maintenance is traded-off with reproduction. This negative relationship between longevity and fecundity is also evident on the molecular level. Exempt from this negative trait association, social insect queens are both extremely long-lived and highly fecund. Here, we study changes in gene expression with age and fecundity in ant queens to understand the molecular basis of their long lifespan. We analyse tissue-specific gene expression in young founding queens and old fecund queens of the ant Temnothorax rugatulus. More genes altered their expression with age in the fat body than in the brain. Despite strong differences in ovary development, few fecundity genes were differentially expressed. Young founding queens invested in immunity (i.e. activation of Toll signalling pathway) and resistance against environmental and physiological stress (i.e. down-regulation of TOR pathway). Conversely, established older queens invested into anti-aging mechanisms through an overproduction of antioxidants (i.e. upregulation of catalase, superoxide dismutase). Finally, we identified candidate genes and pathways, potentially involved in the association between fertility and longevity in social insects and its proximate basis.
Addresses
  • Institute of Organismic and Molecular Evolution, Johannes Gutenberg University of Mainz, Mainz, Germany. negroni@uni-mainz.de.
Autoren
DOI
10.1038/s41598-019-43796-1
eISSN
2045-2322
Externe Identifier
  • PubMed Identifier: 31086243
  • PubMed Central ID: PMC6514213
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: FO 298/19-1
  • Deutsche Forschungsgemeinschaft: DFG FE 1333/6-1
Open access
true
ISSN
2045-2322
Ausgabe der Veröffentlichung
1
Zeitschrift
Scientific reports
Schlüsselwörter
  • Brain
  • Fat Body
  • Animals
  • Ants
  • Antioxidants
  • Gene Expression Profiling
  • Aging
  • Fertility
  • Female
  • Transcriptome
Sprache
eng
Medium
Electronic
Online publication date
2019
Open access status
Open Access
Paginierung
7270
Datum der Veröffentlichung
2019
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2019
Titel
Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://www.nature.com/articles/s41598-019-43796-1.pdf https://europepmc.org/articles/PMC6514213?pdf=render

Data source: Europe PubMed Central

Abstract
Senescence is manifested by an increase in molecular damage and a deterioration of biological functions with age. In most organisms, body maintenance is traded-off with reproduction. This negative relationship between longevity and fecundity is also evident on the molecular level. Exempt from this negative trait association, social insect queens are both extremely long-lived and highly fecund. Here, we study changes in gene expression with age and fecundity in ant queens to understand the molecular basis of their long lifespan. We analyse tissue-specific gene expression in young founding queens and old fecund queens of the ant Temnothorax rugatulus. More genes altered their expression with age in the fat body than in the brain. Despite strong differences in ovary development, few fecundity genes were differentially expressed. Young founding queens invested in immunity (i.e. activation of Toll signalling pathway) and resistance against environmental and physiological stress (i.e. down-regulation of TOR pathway). Conversely, established older queens invested into anti-aging mechanisms through an overproduction of antioxidants (i.e. upregulation of catalase, superoxide dismutase). Finally, we identified candidate genes and pathways, potentially involved in the association between fertility and longevity in social insects and its proximate basis.
Date of acceptance
2019
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31086243
DOI
10.1038/s41598-019-43796-1
eISSN
2045-2322
Externe Identifier
  • PubMed Central ID: PMC6514213
Ausgabe der Veröffentlichung
1
Zeitschrift
Sci Rep
Schlüsselwörter
  • Aging
  • Animals
  • Antioxidants
  • Ants
  • Brain
  • Fat Body
  • Female
  • Fertility
  • Gene Expression Profiling
  • Transcriptome
Sprache
eng
Country
England
Paginierung
7270
PII
10.1038/s41598-019-43796-1
Datum der Veröffentlichung
2019
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
9

Data source: PubMed

Author's licence
CC-BY
Autoren
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
URN
urn:nbn:de:hebis:77-publ-591273
DOI
10.1038/s41598-019-43796-1
Funding acknowledgements
  • DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
File(s) embargoed
false
Open access
true
ISSN
2045-2322
Zeitschrift
Scientific reports
Schlüsselwörter
  • 570 Biowissenschaften
  • 570 Life sciences
Sprache
eng
Open access status
Open Access
Paginierung
Art. 7270
Datum der Veröffentlichung
2019
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/161
Herausgeber
Macmillan Publishers Limited, part of Springer Nature
Herausgeber URL
http://dx.doi.org/10.1038/s41598-019-43796-1
Datum der Datenerfassung
2019
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Zugang
Public
Titel
Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age
Ausgabe der Zeitschrift
9

Files

59127.pdf

Data source: OPENSCIENCE.UB

Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000467709100012&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1038/s41598-019-43796-1
ISSN
2045-2322
Zeitschrift
SCIENTIFIC REPORTS
Artikelnummer
ARTN 7270
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2024
Titel
Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age
Sub types
  • Article
Ausgabe der Zeitschrift
9

Data source: Manual

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