South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe

Publication type:
Journal article
Metadata:
Autoren
  • Maria Grau
  • Monica Guxens
  • Isaac Subirana
  • Montserrat Fito
  • Maria-Isabel Covas
  • Benedicte Jacquemin
  • Jordi Sunyer
  • Timo Lanki
  • Sally Picciotto
  • Tom Bellander
  • Klea Katsouyanni
  • Alexandra Schneider
  • Annette Peters
  • Jaume Marrugat
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000251506200008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1093/eurheartj/ehm446
eISSN
1522-9645
Externe Identifier
  • Clarivate Analytics Document Solution ID: 239GG
  • PubMed Identifier: 17947215
ISSN
0195-668X
Ausgabe der Veröffentlichung
23
Zeitschrift
EUROPEAN HEART JOURNAL
Schlüsselwörter
  • atherosclerosis
  • lipid peroxidation
  • oxidative stress
  • epidemiology
  • coronary artery disease
Paginierung
2841 - 2849
Datum der Veröffentlichung
2007
Status
Published
Titel
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe
Sub types
  • Article
Ausgabe der Zeitschrift
28

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • M Grau
  • M Guxens
  • I Subirana
  • M Fito
  • M-I Covas
  • B Jacquemin
  • J Sunyer
  • T Lanki
  • S Picciotto
  • T Bellander
  • K Katsouyanni
  • A Schneider
  • A Peters
  • J Marrugat
DOI
10.1093/eurheartj/ehm446
eISSN
1522-9645
ISSN
0195-668X
Ausgabe der Veröffentlichung
23
Zeitschrift
European Heart Journal
Sprache
en
Online publication date
2007
Paginierung
2841 - 2849
Status
Published online
Herausgeber
Oxford University Press (OUP)
Herausgeber URL
http://dx.doi.org/10.1093/eurheartj/ehm446
Datum der Datenerfassung
2017
Titel
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe
Ausgabe der Zeitschrift
28

Data source: Crossref

Abstract
<h4>Aims</h4>A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe.<h4>Methods and results</h4>A cross-sectional multicentre study included 790 stable CAD male subjects aged 35-79 years (61.4 +/- 9.5) from six European countries in three regions by latitude: Northern (Finland and Sweden), Central (Germany), and Southern (Greece, Spain, and Italy). Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and lipid profile were significantly associated with oxLDL. The Italian participants had the highest oxLDL levels. A sensitivity analysis showed the models yielded higher adjusted oxLDL values in Northern (63.8 U/L) than in Central (57.6 U/L) and Southern populations (56.5 U/L), P < 0.001, after excluding Italian subjects. The probability of Southern Europe scoring the lowest oxLDL levels was >71% in all fitted models.<h4>Conclusion</h4>Our findings suggest a gradient in LDL oxidation from Southern to Northern Europe that consistently holds for all levels of LDL, except for Italy; this country displays the highest levels in Europe, for unknown reasons.
Addresses
  • Lipids and Cardiovascular Epidemiology Unit, Municipal Institute Medical Research (IMIM) Barcelona, Carrer Dr Aiguader, 88, E-08003 Barcelona, Spain.
Autoren
  • María Grau
  • Mònica Guxens
  • Isaac Subirana
  • Montserrat Fitó
  • María-Isabel Covas
  • Benedicte Jacquemin
  • Jordi Sunyer
  • Timo Lanki
  • Sally Picciotto
  • Tom Bellander
  • Klea Katsouyanni
  • Alexandra Schneider
  • Annette Peters
  • Jaume Marrugat
  • AIRGENE Study Group
DOI
10.1093/eurheartj/ehm446
eISSN
1522-9645
Externe Identifier
  • PubMed Identifier: 17947215
Open access
false
ISSN
0195-668X
Ausgabe der Veröffentlichung
23
Zeitschrift
European heart journal
Schlüsselwörter
  • AIRGENE Study Group
  • Humans
  • Lipoproteins, LDL
  • Cross-Sectional Studies
  • Lipid Peroxidation
  • Adult
  • Aged
  • Middle Aged
  • Europe
  • Male
  • Coronary Artery Disease
  • Biomarkers
Sprache
eng
Medium
Print-Electronic
Online publication date
2007
Paginierung
2841 - 2849
Datum der Veröffentlichung
2007
Status
Published
Datum der Datenerfassung
2007
Titel
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe.
Sub types
  • Research Support, Non-U.S. Gov't
  • Multicenter Study
  • Journal Article
Ausgabe der Zeitschrift
28

Data source: Europe PubMed Central

Abstract
AIMS: A South-to-North gradient across Europe exists for the incidence of coronary artery disease (CAD) rates. Low-density lipoprotein (LDL) oxidation is a hallmark of atherosclerosis and CAD development. The aim of our study was to determine whether differences exist in the degree of LDL oxidation in stable CAD patients from different regions of Europe. METHODS AND RESULTS: A cross-sectional multicentre study included 790 stable CAD male subjects aged 35-79 years (61.4 +/- 9.5) from six European countries in three regions by latitude: Northern (Finland and Sweden), Central (Germany), and Southern (Greece, Spain, and Italy). Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and lipid profile were significantly associated with oxLDL. The Italian participants had the highest oxLDL levels. A sensitivity analysis showed the models yielded higher adjusted oxLDL values in Northern (63.8 U/L) than in Central (57.6 U/L) and Southern populations (56.5 U/L), P < 0.001, after excluding Italian subjects. The probability of Southern Europe scoring the lowest oxLDL levels was >71% in all fitted models. CONCLUSION: Our findings suggest a gradient in LDL oxidation from Southern to Northern Europe that consistently holds for all levels of LDL, except for Italy; this country displays the highest levels in Europe, for unknown reasons.
Autoren
  • María Grau
  • Mònica Guxens
  • Isaac Subirana
  • Montserrat Fitó
  • María-Isabel Covas
  • Benedicte Jacquemin
  • Jordi Sunyer
  • Timo Lanki
  • Sally Picciotto
  • Tom Bellander
  • Klea Katsouyanni
  • Alexandra Schneider
  • Annette Peters
  • Jaume Marrugat
  • AIRGENE Study Group
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17947215
DOI
10.1093/eurheartj/ehm446
ISSN
0195-668X
Ausgabe der Veröffentlichung
23
Zeitschrift
Eur Heart J
Schlüsselwörter
  • Adult
  • Aged
  • Biomarkers
  • Coronary Artery Disease
  • Cross-Sectional Studies
  • Europe
  • Humans
  • Lipid Peroxidation
  • Lipoproteins, LDL
  • Male
  • Middle Aged
Sprache
eng
Country
England
Paginierung
2841 - 2849
PII
ehm446
Datum der Veröffentlichung
2007
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
South-to-North gradient in lipid peroxidation in men with stable coronary artery disease in Europe.
Sub types
  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
28

Data source: PubMed

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