Cytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluation
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Tanja Schirmeister
- Swarna Oli
- Hongmei Wu
- Gerardo Della Sala
- Valeria Costantino
- Ean-Jeong Seo
- Thomas Efferth
- Sammlungen
- metadata
- ISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Marine drugs
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Paginierung
- Art. 63
- Datum der Veröffentlichung
- 2017
- Herausgeber
- Molecular Diversity Preservation International
- Herausgeber URL
- http://dx.doi.org/10.3390/md15030063
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Cytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluation
- Ausgabe der Zeitschrift
- 15
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Autoren
- Tanja Schirmeister
- Swarna Oli
- Hongmei Wu
- Gerardo Della Sala
- Valeria Costantino
- Ean-Jeong Seo
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000398720300012&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/md15030063
- Externe Identifier
- Clarivate Analytics Document Solution ID: ER3TA
- PubMed Identifier: 28273803
- ISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- MARINE DRUGS
- Schlüsselwörter
- Caribbean sponge
- plakortide
- endoperoxide
- leukemia
- multi-drug resistant leukemia
- cytotoxicity
- Artikelnummer
- ARTN 63
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- Cytotoxicity of Endoperoxides from the Caribbean Sponge <i>Plakortis halichondrioides</i> towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation
- Sub types
- Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Web of Science (Lite)
- Autoren
- Tanja Schirmeister
- Swarna Oli
- Hongmei Wu
- Gerardo Della Sala
- Valeria Costantino
- Ean-Jeong Seo
- Thomas Efferth
- DOI
- 10.3390/md15030063
- eISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Marine Drugs
- Sprache
- en
- Online publication date
- 2017
- Paginierung
- 63 - 63
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/md15030063
- Datum der Datenerfassung
- 2018
- Titel
- Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation
- Ausgabe der Zeitschrift
- 15
Datenquelle: Crossref
- Abstract
- The 6-epimer of the plakortide H acid (<b>1</b>), along with the endoperoxides plakortide E (<b>2</b>), plakortin (<b>3</b>), and dihydroplakortin (<b>4</b>) have been isolated from a sample of the Caribbean sponge <i>Plakortis halichondrioides</i>. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (<b>5</b>), as well as the esters plakortide E methyl ester (<b>6</b>) and 6-epi-plakortide H (<b>7</b>) were synthesized by hydrolysis and Steglich esterification, respectively. The data obtained showed that the acids (<b>1</b>, <b>2</b>, <b>5</b>) exhibited potent cytotoxicity towards both cell lines, whereas the esters showed no activity (<b>6</b>, <b>7</b>) or weaker activity (<b>3</b>, <b>4</b>) compared to their corresponding acids. Plakortic acid (<b>5</b>) was the most promising derivative with half maximal inhibitory concentration (IC<sub>50)</sub> values of ca. 0.20 µM for both cell lines.
- Addresses
- Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Staudinger Weg 5, 55128 Mainz, Germany. schirmei@uni-mainz.de.
- Autoren
- Tanja Schirmeister
- Swarna Oli
- Hongmei Wu
- Gerardo Della Sala
- Valeria Costantino
- Ean-Jeong Seo
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.3390/md15030063
- eISSN
- 1660-3397
- Externe Identifier
- PubMed Identifier: 28273803
- PubMed Central ID: PMC5367020
- Open access
- true
- ISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Marine drugs
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Humans
- Porifera
- Plakortis
- Leukemia
- Acids
- Esters
- Dioxanes
- Antineoplastic Agents, Phytogenic
- Drug Screening Assays, Antitumor
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Caribbean Region
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2017
- Open access status
- Open Access
- Paginierung
- E63
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2017
- Titel
- Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 15
Files
https://www.mdpi.com/1660-3397/15/3/63/pdf https://europepmc.org/articles/PMC5367020?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- The 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (5), as well as the esters plakortide E methyl ester (6) and 6-epi-plakortide H (7) were synthesized by hydrolysis and Steglich esterification, respectively. The data obtained showed that the acids (1, 2, 5) exhibited potent cytotoxicity towards both cell lines, whereas the esters showed no activity (6, 7) or weaker activity (3, 4) compared to their corresponding acids. Plakortic acid (5) was the most promising derivative with half maximal inhibitory concentration (IC50) values of ca. 0.20 µM for both cell lines.
- Date of acceptance
- 2017
- Autoren
- Tanja Schirmeister
- Swarna Oli
- Hongmei Wu
- Gerardo Della Sala
- Valeria Costantino
- Ean-Jeong Seo
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28273803
- DOI
- 10.3390/md15030063
- eISSN
- 1660-3397
- Externe Identifier
- PubMed Central ID: PMC5367020
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Mar Drugs
- Schlüsselwörter
- Caribbean sponge
- cytotoxicity
- endoperoxide
- leukemia
- multi-drug resistant leukemia
- plakortide
- Acids
- Animals
- Antineoplastic Agents, Phytogenic
- Caribbean Region
- Cell Line, Tumor
- Dioxanes
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Esters
- Humans
- Leukemia
- Plakortis
- Porifera
- Sprache
- eng
- Country
- Switzerland
- PII
- md15030063
- Datum der Veröffentlichung
- 2017
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: PubMed
- Author's licence
- CC-BY
- Autoren
- Tanja Schirmeister
- Swarna Oli
- Hongmei Wu
- Gerardo Della Sala
- Valeria Costantino
- Ean-Jeong Seo
- Thomas Efferth
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.3390/md15030063
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Marine drugs
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- Art. 63
- Datum der Veröffentlichung
- 2017
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/8157
- Herausgeber
- Molecular Diversity Preservation International
- Herausgeber URL
- http://dx.doi.org/10.3390/md15030063
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Cytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluation
- Ausgabe der Zeitschrift
- 15
Files
cytotoxicity_of_endoperoxides-20220925182710959.pdf
Datenquelle: OPENSCIENCE.UB
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