Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Min-Juan Xu
- Xiao-Jin Liu
- Yi-Lei Zhao
- Dong Liu
- Zhen-Hao Xu
- Xiao-Meng Lang
- Ping Ao
- Wen-Han Lin
- Song-Lin Yang
- Zhi-Gang Zhang
- Jun Xu
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000302136700010&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/md10030639
- Externe Identifier
- Clarivate Analytics Document Solution ID: 916XO
- PubMed Identifier: 22611360
- ISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- MARINE DRUGS
- Schlüsselwörter
- Streptomyces xiamenensis
- mangrove
- benzopyran
- fibroblast
- anti-fibrosis
- anti-contractile capacity
- Paginierung
- 639 - 654
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived <i>Streptomyces xiamenensis</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>An anti-fibrotic compound produced by Streptomyces xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4¢R-methyl-3¢S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts and its structure, including the absolute configuration was determined by extensive spectroscopic data analyses, Mosher’s method, Marfey’s reagent and quantum mechanical calculations. In terms of biological effects, this compound inhibits the proliferation of human lung fibroblasts (WI26), blocks adhesion of human acute monocytic leukemia cells (THP-1) to a monolayer of WI26 cells, and reduces the contractile capacity of WI26 cells in three-dimensional free-floating collagen gels. Altogether, these data indicate that we have identified a bioactive alkaloid (1) with multiple inhibitory biological effects on lung excessive fibrotic characteristics, that are likely involved in fibrosis, suggesting that this molecule might indeed have therapeutic potential against fibrosis.</jats:p>
- Autoren
- Min-Juan Xu
- Xiao-Jin Liu
- Yi-Lei Zhao
- Dong Liu
- Zhen-Hao Xu
- Xiao-Meng Lang
- Ping Ao
- Wen-Han Lin
- Song-Lin Yang
- Zhi-Gang Zhang
- Jun Xu
- DOI
- 10.3390/md10030639
- eISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Marine Drugs
- Sprache
- en
- Online publication date
- 2012
- Paginierung
- 639 - 654
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/md10030639
- Datum der Datenerfassung
- 2024
- Titel
- Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis
- Ausgabe der Zeitschrift
- 10
Datenquelle: Crossref
- Abstract
- An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts and its structure, including the absolute configuration was determined by extensive spectroscopic data analyses, Mosher's method, Marfey's reagent and quantum mechanical calculations. In terms of biological effects, this compound inhibits the proliferation of human lung fibroblasts (WI26), blocks adhesion of human acute monocytic leukemia cells (THP-1) to a monolayer of WI26 cells, and reduces the contractile capacity of WI26 cells in three-dimensional free-floating collagen gels. Altogether, these data indicate that we have identified a bioactive alkaloid (1) with multiple inhibitory biological effects on lung excessive fibrotic characteristics, that are likely involved in fibrosis, suggesting that this molecule might indeed have therapeutic potential against fibrosis.
- Addresses
- Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Key Laboratory of Systems Biomedicine, Shanghai 200240, China.
- Autoren
- Min-Juan Xu
- Xiao-Jin Liu
- Yi-Lei Zhao
- Dong Liu
- Zhen-Hao Xu
- Xiao-Meng Lang
- Ping Ao
- Wen-Han Lin
- Song-Lin Yang
- Zhi-Gang Zhang
- Jun Xu
- DOI
- 10.3390/md10030639
- eISSN
- 1660-3397
- Externe Identifier
- PubMed Identifier: 22611360
- PubMed Central ID: PMC3347021
- Open access
- true
- ISSN
- 1660-3397
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Marine drugs
- Schlüsselwörter
- Cell Line
- Cell Line, Tumor
- Fibroblasts
- Humans
- Streptomyces
- Trees
- Fibrosis
- Benzopyrans
- Collagen
- Indicators and Reagents
- Chromatography, High Pressure Liquid
- Magnetic Resonance Spectroscopy
- Cell Adhesion
- Cell Proliferation
- Molecular Conformation
- Hydrolysis
- Geologic Sediments
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2012
- Open access status
- Open Access
- Paginierung
- 639 - 654
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2012
- Titel
- Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.mdpi.com/1660-3397/10/3/639/pdf?version=1424781438 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22611360/pdf/?tool=EBI https://europepmc.org/articles/PMC3347021?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts and its structure, including the absolute configuration was determined by extensive spectroscopic data analyses, Mosher's method, Marfey's reagent and quantum mechanical calculations. In terms of biological effects, this compound inhibits the proliferation of human lung fibroblasts (WI26), blocks adhesion of human acute monocytic leukemia cells (THP-1) to a monolayer of WI26 cells, and reduces the contractile capacity of WI26 cells in three-dimensional free-floating collagen gels. Altogether, these data indicate that we have identified a bioactive alkaloid (1) with multiple inhibitory biological effects on lung excessive fibrotic characteristics, that are likely involved in fibrosis, suggesting that this molecule might indeed have therapeutic potential against fibrosis.
- Date of acceptance
- 2012
- Autoren
- Min-Juan Xu
- Xiao-Jin Liu
- Yi-Lei Zhao
- Dong Liu
- Zhen-Hao Xu
- Xiao-Meng Lang
- Ping Ao
- Wen-Han Lin
- Song-Lin Yang
- Zhi-Gang Zhang
- Jun Xu
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/22611360
- DOI
- 10.3390/md10030639
- eISSN
- 1660-3397
- Externe Identifier
- PubMed Central ID: PMC3347021
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- Mar Drugs
- Schlüsselwörter
- Streptomyces xiamenensis
- anti-contractile capacity
- anti-fibrosis
- benzopyran
- fibroblast
- mangrove
- Benzopyrans
- Cell Adhesion
- Cell Line
- Cell Line, Tumor
- Cell Proliferation
- Chromatography, High Pressure Liquid
- Collagen
- Fibroblasts
- Fibrosis
- Geologic Sediments
- Humans
- Hydrolysis
- Indicators and Reagents
- Magnetic Resonance Spectroscopy
- Molecular Conformation
- Streptomyces
- Trees
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 639 - 654
- PII
- md10030639
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 10
Datenquelle: PubMed
- Beziehungen:
- Eigentum von