Xylochemical Synthesis and Biological Evaluation of the Orchidaceous Natural Products Isoarundinin I, Bleochrin F, Blestanol K, and Pleionol

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000901968200001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/acs.jnatprod.2c00830
eISSN
1520-6025
Externe Identifier
  • Clarivate Analytics Document Solution ID: 7F6PY
  • PubMed Identifier: 36538372
ISSN
0163-3864
Zeitschrift
JOURNAL OF NATURAL PRODUCTS
Datum der Veröffentlichung
2022
Status
Published
Titel
Xylochemical Synthesis and Biological Evaluation of the Orchidaceous Natural Products Isoarundinin I, Bleochrin F, Blestanol K, and Pleionol
Sub types
  • Article
  • Early Access

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
DOI
10.1021/acs.jnatprod.2c00830
eISSN
1520-6025
ISSN
0163-3864
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of Natural Products
Sprache
en
Online publication date
2022
Paginierung
131 - 137
Datum der Veröffentlichung
2023
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/acs.jnatprod.2c00830
Datum der Datenerfassung
2023
Titel
Xylochemical Synthesis and Biological Evaluation of the Orchidaceous Natural Products Isoarundinin I, Bleochrin F, Blestanol K, and Pleionol
Ausgabe der Zeitschrift
86

Datenquelle: Crossref

Abstract
The first total syntheses of the orchid-derived natural products isoarundinin I (<b>1</b>), (±)-bleochrin F ((±)-<b>2</b>), (±)-blestanol K ((±)-<b>3</b>), and (±)-pleionol ((±)-<b>4</b>) from renewable starting materials are reported, along with the evaluation of their biological activities. The total syntheses were based on regioselective aromatic bromination reactions in combination with a key acid-promoted regioselective intramolecular cyclization. The biological results suggest that isoarundinin I (<b>1</b>), (±)-blestanol K ((±)-<b>3</b>), and (±)-pleionol ((±)-<b>4</b>) have the potential to inhibit the growth of both sensitive and multidrug-resistant cancer cells.
Addresses
  • Department of Chemistry, Organic Chemistry Section, Johannes Gutenberg University, Duesbergweg 10-14, 55128 Mainz, Germany.
Autoren
DOI
10.1021/acs.jnatprod.2c00830
eISSN
1520-6025
Externe Identifier
  • PubMed Identifier: 36538372
Funding acknowledgements
  • Rhineland Palatinate Center for Natural Products Research:
  • German Federal Ministry of Education and Research: 01DG17013
Open access
false
ISSN
0163-3864
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of natural products
Schlüsselwörter
  • Biological Products
  • Drug Resistance, Multiple
  • Cyclization
  • Drug Resistance, Neoplasm
  • Stereoisomerism
  • Halogenation
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Paginierung
131 - 137
Datum der Veröffentlichung
2023
Status
Published
Datum der Datenerfassung
2022
Titel
Xylochemical Synthesis and Biological Evaluation of the Orchidaceous Natural Products Isoarundinin I, Bleochrin F, Blestanol K, and Pleionol.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
86

Datenquelle: Europe PubMed Central

Abstract
The first total syntheses of the orchid-derived natural products isoarundinin I (1), (±)-bleochrin F ((±)-2), (±)-blestanol K ((±)-3), and (±)-pleionol ((±)-4) from renewable starting materials are reported, along with the evaluation of their biological activities. The total syntheses were based on regioselective aromatic bromination reactions in combination with a key acid-promoted regioselective intramolecular cyclization. The biological results suggest that isoarundinin I (1), (±)-blestanol K ((±)-3), and (±)-pleionol ((±)-4) have the potential to inhibit the growth of both sensitive and multidrug-resistant cancer cells.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/36538372
DOI
10.1021/acs.jnatprod.2c00830
eISSN
1520-6025
Ausgabe der Veröffentlichung
1
Zeitschrift
J Nat Prod
Schlüsselwörter
  • Biological Products
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Cyclization
  • Halogenation
  • Stereoisomerism
Sprache
eng
Country
United States
Paginierung
131 - 137
Datum der Veröffentlichung
2023
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Titel
Xylochemical Synthesis and Biological Evaluation of the Orchidaceous Natural Products Isoarundinin I, Bleochrin F, Blestanol K, and Pleionol.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
86

Datenquelle: PubMed

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