RECIPROCAL CORRELATION BETWEEN EXPRESSION OF P-GLYCOPROTEIN AND ACCUMULATION OF RHODAMINE-123 IN HUMAN TUMORS
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- T EFFERTH
- H LOHRKE
- M VOLM
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1989CT66500027&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: CT665
- PubMed Identifier: 2576349
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- ANTICANCER RESEARCH
- Paginierung
- 1633 - 1637
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Titel
- RECIPROCAL CORRELATION BETWEEN EXPRESSION OF P-GLYCOPROTEIN AND ACCUMULATION OF RHODAMINE-123 IN HUMAN TUMORS
- Sub types
- Article
- Ausgabe der Zeitschrift
- 9
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- The aim of this investigation was to determine whether a correlation exists between expression of the multi-drug-resistance associated P-glycoprotein 170 (P-gp170) and the accumulation of rhodamine 123 in human tumors. We investigated a panel of inherently resistant cell lines originating from human kidney tumor specimens and chemotherapeutically pretreated leukemias. The expression of P-gp170 was evaluated by means of two different immunohistological methods using two monoclonal antibodies against P-gp170. We found a significant reciprocal correlation between expression of P-gp170 and accumulation of rhodamine 123. This supports the view that P-gp170 might function as efflux pump in human tumors, as previously described for experimental models.
- Addresses
- German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
- Autoren
- T Efferth
- H Löhrke
- M Volm
- eISSN
- 1791-7530
- Externe Identifier
- PubMed Identifier: 2576349
- Open access
- false
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Anticancer research
- Schlüsselwörter
- Cell Line
- Tumor Cells, Cultured
- Humans
- Leukemia
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Xanthenes
- Rhodamines
- Rhodamine 123
- Membrane Glycoproteins
- Neoplasm Proteins
- Fluorescent Dyes
- Fluorescent Antibody Technique
- Cell Differentiation
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Paginierung
- 1633 - 1637
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Datum der Datenerfassung
- 1989
- Titel
- Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors.
- Sub types
- Comparative Study
- Journal Article
- Ausgabe der Zeitschrift
- 9
Datenquelle: Europe PubMed Central
- Abstract
- The aim of this investigation was to determine whether a correlation exists between expression of the multi-drug-resistance associated P-glycoprotein 170 (P-gp170) and the accumulation of rhodamine 123 in human tumors. We investigated a panel of inherently resistant cell lines originating from human kidney tumor specimens and chemotherapeutically pretreated leukemias. The expression of P-gp170 was evaluated by means of two different immunohistological methods using two monoclonal antibodies against P-gp170. We found a significant reciprocal correlation between expression of P-gp170 and accumulation of rhodamine 123. This supports the view that P-gp170 might function as efflux pump in human tumors, as previously described for experimental models.
- Autoren
- T Efferth
- H Löhrke
- M Volm
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/2576349
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Anticancer Res
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Carcinoma, Renal Cell
- Cell Differentiation
- Cell Line
- Fluorescent Antibody Technique
- Fluorescent Dyes
- Humans
- Kidney Neoplasms
- Leukemia
- Membrane Glycoproteins
- Neoplasm Proteins
- Rhodamine 123
- Rhodamines
- Tumor Cells, Cultured
- Xanthenes
- Sprache
- eng
- Country
- Greece
- Paginierung
- 1633 - 1637
- Datum der Veröffentlichung
- 1989
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1990
- Titel
- Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors.
- Sub types
- Comparative Study
- Journal Article
- Ausgabe der Zeitschrift
- 9
Datenquelle: PubMed
- Beziehungen:
- Eigentum von