Medicinal Chemistry of Paclitaxel and its Analogues

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Y Fu
  • S Li
  • Y Zu
  • G Yang
  • Z Yang
  • M Luo
  • S Jiang
  • M Wink
  • T Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000271382300004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/092986709789352277
eISSN
1875-533X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 514GL
  • PubMed Identifier: 19747129
ISSN
0929-8673
Ausgabe der Veröffentlichung
30
Zeitschrift
CURRENT MEDICINAL CHEMISTRY
Schlüsselwörter
  • Paclitaxel
  • Docetaxel
  • Taxane
  • Anti-cancer
  • Mechanism
  • SAR
  • Bioreactor
  • Taxus
Paginierung
3966 - 3985
Datum der Veröffentlichung
2009
Status
Published
Titel
Medicinal Chemistry of Paclitaxel and its Analogues
Sub types
  • Review
Ausgabe der Zeitschrift
16

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Y Fu
  • S Li
  • Y Zu
  • G Yang
  • Z Yang
  • M Luo
  • S Jiang
  • M Wink
  • T Efferth
DOI
10.2174/092986709789352277
ISSN
0929-8673
Ausgabe der Veröffentlichung
30
Zeitschrift
Current Medicinal Chemistry
Sprache
en
Paginierung
3966 - 3985
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/092986709789352277
Datum der Datenerfassung
2015
Titel
Medicinal Chemistry of Paclitaxel and its Analogues
Ausgabe der Zeitschrift
16

Datenquelle: Crossref

Abstract
Paclitaxel belongs to the most successful anticancer drugs developed and utilised during the past two decades. Nevertheless, the development of resistance of tumor cells and severe side effects in the patients require further improvement of the drug. In this review, we provide a detailed overview of the state-of-the-art in the medicinal chemistry of paclitaxel and its analogues. A number of strategies have been explored to obtain sufficient amounts of paclitaxel for clinical use from natural resources. Semi-synthesis from its precursor, 10-deacetylbaccatin III, which can be extracted from Taxus leavesturned out as the most appropriate method for commercial production. So far, many paclitaxel derivatives have been synthesized, and their effect on microtubules stabilization and cytotoxicity were investigated in terms of structure-activity relationships (SAR). One of them, docetaxel, was approved as a more potent anticancer agent than paclitaxel towards a variety of tumor types. This review summarizes current possibilities to harvest sufficient amount of drugs from natural sources, including the production of taxanes in bioreactors and synthetic approaches for paclitaxel and its analogues, their mechanism of action and structure-activity relationships. In addition, future developments and perspectives for this class of compounds are outlined.
Addresses
  • Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China. yujie_fu2002@yahoo.com
Autoren
  • Y Fu
  • S Li
  • Y Zu
  • G Yang
  • Z Yang
  • M Luo
  • S Jiang
  • M Wink
  • T Efferth
  • T Efferth
DOI
10.2174/092986709789352277
eISSN
1875-533X
Externe Identifier
  • PubMed Identifier: 19747129
Open access
false
ISSN
0929-8673
Ausgabe der Veröffentlichung
30
Zeitschrift
Current medicinal chemistry
Schlüsselwörter
  • Animals
  • Humans
  • Paclitaxel
  • Antineoplastic Agents, Phytogenic
  • Models, Molecular
Sprache
eng
Medium
Print
Paginierung
3966 - 3985
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Medicinal chemistry of paclitaxel and its analogues.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
16

Datenquelle: Europe PubMed Central

Abstract
Paclitaxel belongs to the most successful anticancer drugs developed and utilised during the past two decades. Nevertheless, the development of resistance of tumor cells and severe side effects in the patients require further improvement of the drug. In this review, we provide a detailed overview of the state-of-the-art in the medicinal chemistry of paclitaxel and its analogues. A number of strategies have been explored to obtain sufficient amounts of paclitaxel for clinical use from natural resources. Semi-synthesis from its precursor, 10-deacetylbaccatin III, which can be extracted from Taxus leavesturned out as the most appropriate method for commercial production. So far, many paclitaxel derivatives have been synthesized, and their effect on microtubules stabilization and cytotoxicity were investigated in terms of structure-activity relationships (SAR). One of them, docetaxel, was approved as a more potent anticancer agent than paclitaxel towards a variety of tumor types. This review summarizes current possibilities to harvest sufficient amount of drugs from natural sources, including the production of taxanes in bioreactors and synthetic approaches for paclitaxel and its analogues, their mechanism of action and structure-activity relationships. In addition, future developments and perspectives for this class of compounds are outlined.
Date of acceptance
2009
Autoren
  • Y Fu
  • S Li
  • Y Zu
  • G Yang
  • Z Yang
  • M Luo
  • S Jiang
  • M Wink
  • T Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19747129
DOI
10.2174/092986709789352277
eISSN
1875-533X
Ausgabe der Veröffentlichung
30
Zeitschrift
Curr Med Chem
Schlüsselwörter
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Humans
  • Models, Molecular
  • Paclitaxel
Sprache
eng
Country
United Arab Emirates
Paginierung
3966 - 3985
PII
CMC - AbsEpub - 037
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
Medicinal chemistry of paclitaxel and its analogues.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
16

Datenquelle: PubMed

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