Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000473047100002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2018.11.004
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: IF4JH
  • PubMed Identifier: 30901664
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Chemobrain
  • Chemotherapy
  • Neurotoxicity
  • Phytotherapy
Artikelnummer
ARTN 152743
Datum der Veröffentlichung
2019
Status
Published
Titel
Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells
Sub types
  • Article
Ausgabe der Zeitschrift
58

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
DOI
10.1016/j.phymed.2018.11.004
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
152743
Paginierung
152743 - 152743
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2018.11.004
Datum der Datenerfassung
2019
Titel
Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells
Ausgabe der Zeitschrift
58

Datenquelle: Crossref

Abstract
<h4>Background</h4>Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al., 2018), we demonstrated that selected adaptogenic extracts significantly attenuate cytostatic-induced regulation of more than 100 genes involved in the activation of neuronal death and inhibiting neurogenesis. Neuroprotective and cytoprotective activities of adaptogens rise the question about their possible impact on cytostatic effects of a chemotherapeutic combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC).<h4>Aim</h4>The aim of this study was to assess the effects of selected adaptogenic herbal extracts, namely of andrographolide (AND), Herba Andrographidis (AP), Radix Eleutherococci (ES) genuine extracts, their fixed combination (AE), and the combination of three adaptogenic herbs, Rhodiola Radix, Shisandra Fructus and Eleutherococci Radix (RSE) on the cytotoxicity of a fixed combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC) on neuroglia cells.<h4>Methods</h4>Cytotoxicity of FEC, adaptogenic extracts and their combination with FEC was tested on isolated T98G cells in a wide range of concentrations of all tested compounds.<h4>Results</h4>FEC reproducibly inhibited the proliferation of T98G cells by 50% at concentrations of 5 × 10<sup>-1</sup> µg/ml epirubicin, 500 × 10<sup>-1</sup> µg/ml 5-fluorouracil and 20 × 10<sup>-1</sup> µg/ml 4-hydroperoxycyclophosphamide after 24 h incubation of cells. These concentrations were subsequently used for experiments with adaptogenic extracts. The cytotoxic activity of FEC was not significantly changed in the presence of AND, ES and AE. Furthermore, it was potentiated by AP extract and RSE in concentrations of 0.06-6 µg/ml and 17.6-26.4 µg/ml.<h4>Conclusion</h4>The neuroprotective effect of adaptogens did not attenuate the cytotoxic activity of FEC. Application of cytostatic drugs in combination with adaptogenic plant extracts likely have no impact in cytotoxic effect of FEC. Furthermore, AP and RSE potentiated the cytotoxic effects of FEC.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
Autoren
DOI
10.1016/j.phymed.2018.11.004
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 30901664
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Neuroglia
  • Cell Line
  • Humans
  • Andrographis
  • Eleutherococcus
  • Rhodiola
  • Cyclophosphamide
  • Fluorouracil
  • Epirubicin
  • Neuroprotective Agents
  • Plant Extracts
  • Antineoplastic Combined Chemotherapy Protocols
  • Dose-Response Relationship, Drug
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
152743
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2019
Titel
Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
58

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al., 2018), we demonstrated that selected adaptogenic extracts significantly attenuate cytostatic-induced regulation of more than 100 genes involved in the activation of neuronal death and inhibiting neurogenesis. Neuroprotective and cytoprotective activities of adaptogens rise the question about their possible impact on cytostatic effects of a chemotherapeutic combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC). AIM: The aim of this study was to assess the effects of selected adaptogenic herbal extracts, namely of andrographolide (AND), Herba Andrographidis (AP), Radix Eleutherococci (ES) genuine extracts, their fixed combination (AE), and the combination of three adaptogenic herbs, Rhodiola Radix, Shisandra Fructus and Eleutherococci Radix (RSE) on the cytotoxicity of a fixed combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC) on neuroglia cells. METHODS: Cytotoxicity of FEC, adaptogenic extracts and their combination with FEC was tested on isolated T98G cells in a wide range of concentrations of all tested compounds. RESULTS: FEC reproducibly inhibited the proliferation of T98G cells by 50% at concentrations of 5 × 10-1 µg/ml epirubicin, 500 × 10-1 µg/ml 5-fluorouracil and 20 × 10-1 µg/ml 4-hydroperoxycyclophosphamide after 24 h incubation of cells. These concentrations were subsequently used for experiments with adaptogenic extracts. The cytotoxic activity of FEC was not significantly changed in the presence of AND, ES and AE. Furthermore, it was potentiated by AP extract and RSE in concentrations of 0.06-6 µg/ml and 17.6-26.4 µg/ml. CONCLUSION: The neuroprotective effect of adaptogens did not attenuate the cytotoxic activity of FEC. Application of cytostatic drugs in combination with adaptogenic plant extracts likely have no impact in cytotoxic effect of FEC. Furthermore, AP and RSE potentiated the cytotoxic effects of FEC.
Date of acceptance
2018
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30901664
DOI
10.1016/j.phymed.2018.11.004
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Chemobrain
  • Chemotherapy
  • Neurotoxicity
  • Phytotherapy
  • Andrographis
  • Antineoplastic Combined Chemotherapy Protocols
  • Cell Line
  • Cyclophosphamide
  • Dose-Response Relationship, Drug
  • Eleutherococcus
  • Epirubicin
  • Fluorouracil
  • Humans
  • Neuroglia
  • Neuroprotective Agents
  • Plant Extracts
  • Rhodiola
Sprache
eng
Country
Germany
Paginierung
152743
PII
S0944-7113(18)30561-0
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
58

Datenquelle: PubMed

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