Shikonin derivatives for cancer prevention and therapy

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Joelle C Boulos
  • Muhammad Rahama
  • Mohamed-Elamir F Hegazy
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000480670800024&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.canlet.2019.04.033
eISSN
1872-7980
Externe Identifier
  • Clarivate Analytics Document Solution ID: IQ3SG
  • PubMed Identifier: 31132429
ISSN
0304-3835
Zeitschrift
CANCER LETTERS
Schlüsselwörter
  • Chemotherapy
  • Immunotherapy
  • Naphthoquinone
  • Nanotechnology
  • Phytochemical
  • Synergistic interactions
Paginierung
248 - 267
Datum der Veröffentlichung
2019
Status
Published
Titel
Shikonin derivatives for cancer prevention and therapy
Sub types
  • Article
Ausgabe der Zeitschrift
459

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Joelle C Boulos
  • Muhammad Rahama
  • Mohamed-Elamir F Hegazy
  • Thomas Efferth
DOI
10.1016/j.canlet.2019.04.033
ISSN
0304-3835
Zeitschrift
Cancer Letters
Sprache
en
Paginierung
248 - 267
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.canlet.2019.04.033
Datum der Datenerfassung
2020
Titel
Shikonin derivatives for cancer prevention and therapy
Ausgabe der Zeitschrift
459

Datenquelle: Crossref

Abstract
Phytochemicals gained considerable interest during the past years as source to develop new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a majority of established anticancer drugs are derived in one way or another from natural resources, we focused on shikonin, a naphthoquinone with high potentials to be further developed as preventive or therapeutic drug to fight cancer. Shikonin is the major chemical component of Lithospermum erythrorhizon (Purple Cromwell) roots. Traditionally, the root extract has been applied to cure dermatitis, burns, and wounds. Over the past three decades, the anti-inflammatory and anticancer effects of root extracts, isolated shikonin as well as semi-synthetic and synthetic derivatives and nanoformulations have been described. In vitro and in vivo experiments were conducted to understand the effect of shikonin at cellular and molecular levels. Preliminary clinical trials indicate the potential of shikonin for translation into clinical oncology. Shikonin exerts additive and synergistic interactions in combination with established chemotherapeutics, immunotherapeutic approaches, radiotherapy and other treatment modalities, which further underscores the potential of this phytochemical to be integrated into standard treatment regimens.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.
Autoren
  • Joelle C Boulos
  • Muhammad Rahama
  • Mohamed-Elamir F Hegazy
  • Thomas Efferth
DOI
10.1016/j.canlet.2019.04.033
eISSN
1872-7980
Externe Identifier
  • PubMed Identifier: 31132429
Funding acknowledgements
  • Alexander von Humboldt Foundation:
Open access
false
ISSN
0304-3835
Zeitschrift
Cancer letters
Schlüsselwörter
  • Animals
  • Humans
  • Neoplasms
  • Naphthoquinones
  • Drugs, Chinese Herbal
  • Antineoplastic Agents, Phytogenic
  • Structure-Activity Relationship
  • Models, Molecular
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Paginierung
248 - 267
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2019
Titel
Shikonin derivatives for cancer prevention and therapy.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
459

Datenquelle: Europe PubMed Central

Abstract
Phytochemicals gained considerable interest during the past years as source to develop new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a majority of established anticancer drugs are derived in one way or another from natural resources, we focused on shikonin, a naphthoquinone with high potentials to be further developed as preventive or therapeutic drug to fight cancer. Shikonin is the major chemical component of Lithospermum erythrorhizon (Purple Cromwell) roots. Traditionally, the root extract has been applied to cure dermatitis, burns, and wounds. Over the past three decades, the anti-inflammatory and anticancer effects of root extracts, isolated shikonin as well as semi-synthetic and synthetic derivatives and nanoformulations have been described. In vitro and in vivo experiments were conducted to understand the effect of shikonin at cellular and molecular levels. Preliminary clinical trials indicate the potential of shikonin for translation into clinical oncology. Shikonin exerts additive and synergistic interactions in combination with established chemotherapeutics, immunotherapeutic approaches, radiotherapy and other treatment modalities, which further underscores the potential of this phytochemical to be integrated into standard treatment regimens.
Date of acceptance
2019
Autoren
  • Joelle C Boulos
  • Muhammad Rahama
  • Mohamed-Elamir F Hegazy
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31132429
DOI
10.1016/j.canlet.2019.04.033
eISSN
1872-7980
Zeitschrift
Cancer Lett
Schlüsselwörter
  • Chemotherapy
  • Immunotherapy
  • Nanotechnology
  • Naphthoquinone
  • Phytochemical
  • Synergistic interactions
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Humans
  • Models, Molecular
  • Naphthoquinones
  • Neoplasms
  • Structure-Activity Relationship
Sprache
eng
Country
Ireland
Paginierung
248 - 267
PII
S0304-3835(19)30270-8
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Shikonin derivatives for cancer prevention and therapy.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
459

Datenquelle: PubMed

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