Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Ana Sanches-Silva
- Lara Testai
- Seyed Fazel Nabavi
- Maurizio Battino
- Kasi Pandima Devi
- Silvia Tejada
- Antoni Sureda
- Suowen Xu
- Bahman Yousefi
- Maryam Majidinia
- Gian Luigi Russo
- Thomas Efferth
- Seyed Mohammad Nabavi
- Mohammad Hossein Farzaei
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000518700200011&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phrs.2019.104626
- Externe Identifier
- Clarivate Analytics Document Solution ID: KT0KU
- PubMed Identifier: 31904507
- ISSN
- 1043-6618
- Zeitschrift
- PHARMACOLOGICAL RESEARCH
- Schlüsselwörter
- Cardiovascular diseases
- mTOR
- Polyphenols
- Natural product
- Transcription factor
- Artikelnummer
- ARTN 104626
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway
- Sub types
- Review
- Ausgabe der Zeitschrift
- 152
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Ana Sanches-Silva
- Lara Testai
- Seyed Fazel Nabavi
- Maurizio Battino
- Kasi Pandima Devi
- Silvia Tejada
- Antoni Sureda
- Suowen Xu
- Bahman Yousefi
- Maryam Majidinia
- Gian Luigi Russo
- Thomas Efferth
- Seyed Mohammad Nabavi
- Mohammad Hossein Farzaei
- DOI
- 10.1016/j.phrs.2019.104626
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological Research
- Sprache
- en
- Artikelnummer
- 104626
- Paginierung
- 104626 - 104626
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phrs.2019.104626
- Datum der Datenerfassung
- 2023
- Titel
- Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway
- Ausgabe der Zeitschrift
- 152
Datenquelle: Crossref
- Abstract
- Cardiovascular diseases comprise of non-communicable disorders that involve the heart and/or blood vessels and have become the leading cause of death worldwide with increased prevalence by age. mTOR is a serine/threonine-specific protein kinase which plays a central role in many physiological processes including cardiovascular diseases, and also integrates various proliferative signals, nutrient and energy abundance and stressful situations. mTOR also acts as central regulator during chronic stress, mitochondrial dysfunction and deregulated autophagy which are associated with senescence. Under oxidative stress, mTOR has been reported to exert protective effects regulating apoptosis and autophagy processes and favoring tissue repair. On the other hand, inhibition of mTOR has been suggested to have beneficial effects against atherosclerosis, cardiac hypertrophy and heart failure, and also in extending the lifespan. In this aspect, the use of drugs or natural compounds, which can target mTOR is an interesting approach in order to reduce the number of deaths caused by cardiovascular disease. In the present review, we intend to shed light on the possible effects and molecular mechanism of natural agents like polyphenols via regulating mTOR.
- Addresses
- National Institute for Agricultural and Veterinary Research (INIAV), Vairão, Vila do Conde, Portugal; Center for Study in Animal Science (CECA), ICETA, University of Porto, Porto, Portugal.
- Autoren
- Ana Sanches-Silva
- Lara Testai
- Seyed Fazel Nabavi
- Maurizio Battino
- Kasi Pandima Devi
- Silvia Tejada
- Antoni Sureda
- Suowen Xu
- Bahman Yousefi
- Maryam Majidinia
- Gian Luigi Russo
- Thomas Efferth
- Seyed Mohammad Nabavi
- Mohammad Hossein Farzaei
- DOI
- 10.1016/j.phrs.2019.104626
- eISSN
- 1096-1186
- Externe Identifier
- PubMed Identifier: 31904507
- Funding acknowledgements
- RUSA 2.0: F. 24-51/2014-U
- Programme of Promotion of Biomedical Research:
- Instituto de Salud Carlos III, Spain: CB12/03/30038
- Health Sciences CIBEROBN:
- Computational and Bioinformatics Facility:
- Alagappa University Bioinformatics Infrastructure Facility: BT/BI/25/012/2012
- UGC-SAP: F.5-1/2018/DRS-II(SAP-II)
- DST-FIST: SR/FST/LSI-639/2015(C)
- Spanish government:
- DST-PURSE: SR/PURSE
- Open access
- false
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological research
- Schlüsselwörter
- Animals
- Humans
- Cardiovascular Diseases
- Signal Transduction
- TOR Serine-Threonine Kinases
- Polyphenols
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Paginierung
- 104626
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum der Datenerfassung
- 2020
- Titel
- Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 152
Datenquelle: Europe PubMed Central
- Abstract
- Cardiovascular diseases comprise of non-communicable disorders that involve the heart and/or blood vessels and have become the leading cause of death worldwide with increased prevalence by age. mTOR is a serine/threonine-specific protein kinase which plays a central role in many physiological processes including cardiovascular diseases, and also integrates various proliferative signals, nutrient and energy abundance and stressful situations. mTOR also acts as central regulator during chronic stress, mitochondrial dysfunction and deregulated autophagy which are associated with senescence. Under oxidative stress, mTOR has been reported to exert protective effects regulating apoptosis and autophagy processes and favoring tissue repair. On the other hand, inhibition of mTOR has been suggested to have beneficial effects against atherosclerosis, cardiac hypertrophy and heart failure, and also in extending the lifespan. In this aspect, the use of drugs or natural compounds, which can target mTOR is an interesting approach in order to reduce the number of deaths caused by cardiovascular disease. In the present review, we intend to shed light on the possible effects and molecular mechanism of natural agents like polyphenols via regulating mTOR.
- Date of acceptance
- 2019
- Autoren
- Ana Sanches-Silva
- Lara Testai
- Seyed Fazel Nabavi
- Maurizio Battino
- Kasi Pandima Devi
- Silvia Tejada
- Antoni Sureda
- Suowen Xu
- Bahman Yousefi
- Maryam Majidinia
- Gian Luigi Russo
- Thomas Efferth
- Seyed Mohammad Nabavi
- Mohammad Hossein Farzaei
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/31904507
- DOI
- 10.1016/j.phrs.2019.104626
- eISSN
- 1096-1186
- Zeitschrift
- Pharmacol Res
- Schlüsselwörter
- Ascomycin (CID: 5282071)
- Cardiovascular diseases
- Curcumin (PubChem CID: 969516)
- Epigallocatechingallate (CID: 65064)
- Honokiol (CID: 72303)
- Macrolactam FK-506(tacrolimus) (CID: 445643)
- Metformin (CID: 4091)
- Natural product
- Oleuropein (CID: 5281544)
- Polyphenols
- Quercetin (CID: 5280343)
- Rapamycin (CID: 5284616)
- Resveratrol (CID: 445154)
- Transcription factor
- mTOR
- Animals
- Cardiovascular Diseases
- Humans
- Polyphenols
- Signal Transduction
- TOR Serine-Threonine Kinases
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 104626
- PII
- S1043-6618(19)31430-6
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 152
Datenquelle: PubMed
- Beziehungen:
- Eigentum von