Altered neural responses to social fairness in bipolar disorder
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Giannis Lois
- Eva E Schneider
- Aleksandra Kaurin
- Michele Wessa
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000600619100129&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.nicl.2020.102487
- Externe Identifier
- Clarivate Analytics Document Solution ID: PH7WY
- PubMed Identifier: 33395978
- ISSN
- 2213-1582
- Zeitschrift
- NEUROIMAGE-CLINICAL
- Schlüsselwörter
- Bipolar disorder
- Social decision-making
- Ultimatum game
- Fairness
- Ambiguity
- Artikelnummer
- ARTN 102487
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Altered neural responses to social fairness in bipolar disorder
- Sub types
- Article
- Ausgabe der Zeitschrift
- 28
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Giannis Lois
- Eva E Schneider
- Aleksandra Kaurin
- Michèle Wessa
- DOI
- 10.1016/j.nicl.2020.102487
- ISSN
- 2213-1582
- Zeitschrift
- NeuroImage: Clinical
- Sprache
- en
- Artikelnummer
- 102487
- Paginierung
- 102487 - 102487
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.nicl.2020.102487
- Datum der Datenerfassung
- 2022
- Titel
- Altered neural responses to social fairness in bipolar disorder
- Ausgabe der Zeitschrift
- 28
Datenquelle: Crossref
- Abstract
- Bipolar Disorder (BD) has a debilitating impact on psychosocial functioning and social decision-making. Recent evidence using the Ultimatum Game (UG) has shown increased rejection of moderately unfair offers in BD, suggesting impaired processing of ambiguous social information related to fairness. The present study builds upon this finding to investigate the neural substrates of fairness processing in BD. During functional magnetic resonance imaging scanning, euthymic BD patients (n = 41) and matched healthy controls (HC; n = 41) accepted or rejected very unfair, moderately unfair, or fair offers in the UG. Acceptance rates of moderately unfair offers were significantly lower in BD patients. This aberrant behavior co-occurred with abnormal brain responses to moderately unfair offers. Compared to HC, BD patients exhibited hypoactivation of right anterior insula in response to moderately unfair offers suggesting impaired integration of affective and contextual information. BD patients also displayed stronger deactivation of posterior and middle insula in response to moderately unfair offers reflecting impaired processing of the contextual aspects of fairness. The level of impulsivity of BD patients positively correlated with the abnormal deactivation of posterior and middle insula. A separate analysis revealed increased activation of dorsal ACC and left ventrolateral PFC in response to rejected compared to accepted offers in BD patients. Taken together, our findings suggest impaired processing of ambiguous social information in euthymic BD patients which is associated with increased rejection of moderately unfair offers. This impairment may reflect a failure to integrate contextual information and may be related to increased trait impulsivity.
- Addresses
- Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Germany; Department of Microeconomics and Public Economics, School of Business and Economics, Maastricht University, The Netherlands. Electronic address: i.lois@maastrichtuniversity.nl.
- Autoren
- Giannis Lois
- Eva E Schneider
- Aleksandra Kaurin
- Michèle Wessa
- DOI
- 10.1016/j.nicl.2020.102487
- eISSN
- 2213-1582
- Externe Identifier
- PubMed Identifier: 33395978
- PubMed Central ID: PMC7666350
- Open access
- true
- ISSN
- 2213-1582
- Zeitschrift
- NeuroImage. Clinical
- Schlüsselwörter
- Humans
- Magnetic Resonance Imaging
- Brain Mapping
- Social Behavior
- Decision Making
- Bipolar Disorder
- Games, Experimental
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Open access status
- Open Access
- Paginierung
- 102487
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2021
- Titel
- Altered neural responses to social fairness in bipolar disorder.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 28
Files
https://europepmc.org/articles/PMC7666350?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Bipolar Disorder (BD) has a debilitating impact on psychosocial functioning and social decision-making. Recent evidence using the Ultimatum Game (UG) has shown increased rejection of moderately unfair offers in BD, suggesting impaired processing of ambiguous social information related to fairness. The present study builds upon this finding to investigate the neural substrates of fairness processing in BD. During functional magnetic resonance imaging scanning, euthymic BD patients (n = 41) and matched healthy controls (HC; n = 41) accepted or rejected very unfair, moderately unfair, or fair offers in the UG. Acceptance rates of moderately unfair offers were significantly lower in BD patients. This aberrant behavior co-occurred with abnormal brain responses to moderately unfair offers. Compared to HC, BD patients exhibited hypoactivation of right anterior insula in response to moderately unfair offers suggesting impaired integration of affective and contextual information. BD patients also displayed stronger deactivation of posterior and middle insula in response to moderately unfair offers reflecting impaired processing of the contextual aspects of fairness. The level of impulsivity of BD patients positively correlated with the abnormal deactivation of posterior and middle insula. A separate analysis revealed increased activation of dorsal ACC and left ventrolateral PFC in response to rejected compared to accepted offers in BD patients. Taken together, our findings suggest impaired processing of ambiguous social information in euthymic BD patients which is associated with increased rejection of moderately unfair offers. This impairment may reflect a failure to integrate contextual information and may be related to increased trait impulsivity.
- Date of acceptance
- 2020
- Autoren
- Giannis Lois
- Eva E Schneider
- Aleksandra Kaurin
- Michèle Wessa
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33395978
- DOI
- 10.1016/j.nicl.2020.102487
- eISSN
- 2213-1582
- Externe Identifier
- PubMed Central ID: PMC7666350
- Zeitschrift
- Neuroimage Clin
- Schlüsselwörter
- Ambiguity
- Bipolar disorder
- Fairness
- Social decision-making
- Ultimatum game
- Bipolar Disorder
- Brain Mapping
- Decision Making
- Games, Experimental
- Humans
- Magnetic Resonance Imaging
- Social Behavior
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 102487
- PII
- S2213-1582(20)30324-7
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Altered neural responses to social fairness in bipolar disorder.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 28
Datenquelle: PubMed
- Beziehungen:
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