No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- D Hernaus
- D Collip
- Z Kasanova
- O Winz
- A Heinzel
- T van Amelsvoort
- SM Shali
- J Booij
- Y Rong
- M Piel
- J Pruessner
- FM Mottaghy
- I Myin-Germeys
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000367655500001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1038/tp.2015.37
- Externe Identifier
- Clarivate Analytics Document Solution ID: DA2VS
- PubMed Identifier: 25871972
- ISSN
- 2158-3188
- Zeitschrift
- TRANSLATIONAL PSYCHIATRY
- Artikelnummer
- ARTN e547
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Titel
- No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder
- Sub types
- Article
- Ausgabe der Zeitschrift
- 5
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [<jats:sup>18</jats:sup>F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [<jats:sup>18</jats:sup>F]fallypride displacement and the spatial extent of stress-induced [<jats:sup>18</jats:sup>F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [<jats:sup>18</jats:sup>F]fallypride displacement nor the spatial extent of stress-induced [<jats:sup>18</jats:sup>F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.</jats:p>
- Autoren
- D Hernaus
- D Collip
- Z Kasanova
- O Winz
- A Heinzel
- T van Amelsvoort
- SM Shali
- J Booij
- Y Rong
- M Piel
- J Pruessner
- FM Mottaghy
- I Myin-Germeys
- DOI
- 10.1038/tp.2015.37
- eISSN
- 2158-3188
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Translational Psychiatry
- Sprache
- en
- Online publication date
- 2015
- Paginierung
- e547 - e547
- Status
- Published online
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1038/tp.2015.37
- Datum der Datenerfassung
- 2023
- Titel
- No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder
- Ausgabe der Zeitschrift
- 5
Datenquelle: Crossref
- Abstract
- Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.
- Addresses
- Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands.
- Autoren
- D Hernaus
- D Collip
- Z Kasanova
- O Winz
- A Heinzel
- T van Amelsvoort
- SM Shali
- J Booij
- Y Rong
- M Piel
- J Pruessner
- FM Mottaghy
- I Myin-Germeys
- DOI
- 10.1038/tp.2015.37
- eISSN
- 2158-3188
- Externe Identifier
- PubMed Identifier: 25871972
- PubMed Central ID: PMC4462602
- Open access
- true
- ISSN
- 2158-3188
- Zeitschrift
- Translational psychiatry
- Schlüsselwörter
- Brain
- Neostriatum
- Prefrontal Cortex
- Temporal Lobe
- Humans
- Fluorine Radioisotopes
- Benzamides
- Dopamine
- Positron-Emission Tomography
- Case-Control Studies
- Stress, Psychological
- Psychotic Disorders
- Synaptic Transmission
- Adult
- Middle Aged
- Female
- Male
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2015
- Open access status
- Open Access
- Paginierung
- e547
- Datum der Veröffentlichung
- 2015
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2015
- Titel
- No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 5
Files
https://www.nature.com/articles/tp201537.pdf https://europepmc.org/articles/PMC4462602?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.
- Date of acceptance
- 2015
- Autoren
- D Hernaus
- D Collip
- Z Kasanova
- O Winz
- A Heinzel
- T van Amelsvoort
- SM Shali
- J Booij
- Y Rong
- M Piel
- J Pruessner
- FM Mottaghy
- I Myin-Germeys
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25871972
- DOI
- 10.1038/tp.2015.37
- eISSN
- 2158-3188
- Externe Identifier
- PubMed Central ID: PMC4462602
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Transl Psychiatry
- Schlüsselwörter
- Adult
- Benzamides
- Brain
- Case-Control Studies
- Dopamine
- Female
- Fluorine Radioisotopes
- Humans
- Male
- Middle Aged
- Neostriatum
- Positron-Emission Tomography
- Prefrontal Cortex
- Psychotic Disorders
- Stress, Psychological
- Synaptic Transmission
- Temporal Lobe
- Sprache
- eng
- Country
- United States
- Paginierung
- e547
- PII
- tp201537
- Datum der Veröffentlichung
- 2015
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2016
- Titel
- No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 5
Datenquelle: PubMed
- Autoren
- Dennis Hernaus
- Dina Collip
- Zuzana Kasanova
- Oliver Winz
- Alexander Heinzel
- Thérèse Van Amelsvoort
- Siamak Mohammadkhani Shali
- Jan Booij
- Ye Rong
- Markus Piel
- others
- Zeitschrift
- Translational psychiatry
- Artikelnummer
- 4
- Paginierung
- e547 - e547
- Datum der Veröffentlichung
- 2015
- Herausgeber
- Nature Publishing Group
- Datum der Datenerfassung
- 2021
- Titel
- No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder
- Sub types
- article
- Ausgabe der Zeitschrift
- 5
Datenquelle: Manual
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