Improved automated synthesis of [18F] fluoroethylcholine as a radiotracer for cancer imaging
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- M Piel
- A Bauman
- RP Baum
- S Hoehnemann
- I Klette
- R Wortmann
- F Roesch
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000246002800008&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.bmc.2007.02.038
- eISSN
- 1464-3391
- Externe Identifier
- Clarivate Analytics Document Solution ID: 161GO
- PubMed Identifier: 17346977
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- BIOORGANIC & MEDICINAL CHEMISTRY
- Schlüsselwörter
- [F-18]fluoroethylcholine
- F-18-fluoroalkylation
- positron emission tomography
- Paginierung
- 3171 - 3175
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Titel
- Improved automated synthesis of [<SUP>18</SUP>F]fluoroethylcholine as a radiotracer for cancer imaging
- Sub types
- Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- M Piel
- A Bauman
- RP Baum
- S Höhnemann
- I Klette
- R Wortmann
- F Rösch
- DOI
- 10.1016/j.bmc.2007.02.038
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Bioorganic & Medicinal Chemistry
- Sprache
- en
- Paginierung
- 3171 - 3175
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.bmc.2007.02.038
- Datum der Datenerfassung
- 2021
- Titel
- Improved automated synthesis of [18F]fluoroethylcholine as a radiotracer for cancer imaging
- Ausgabe der Zeitschrift
- 15
Datenquelle: Crossref
- Abstract
- [(18)F]Fluoroethylcholine has been recently introduced as a promising (18)F-labelled analogue of [(11)C]choline which had been previously described as a tracer for metabolic cancer imaging with positron emission tomography (PET). Due to the practical advantages of using the longer-lived radioisotope (18)F (t(1/2)=110 min), offering the opportunity of a more widespread clinical application, we established a reliable, fully automated synthesis for its production using a modified, commercially available module. [(18)F]Fluoroethylcholine was prepared from N,N-dimethylaminoethanol by iodide catalyzed alkylation with 1-[(18)F]fluoro-2-tosylethane as alkylating agent, resulting in a total radiochemical yield of 30+/-6% after a synthesis time of 50 min. The specific activity of [(18)F]fluoroethylcholine was >55 GBq/micromol and the radiochemical purity 95-99%.
- Addresses
- Institute of Nuclear Chemistry, Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany. piel@mail.uni-mainz.de <piel@mail.uni-mainz.de>
- Autoren
- M Piel
- A Bauman
- RP Baum
- S Höhnemann
- I Klette
- R Wortmann
- F Rösch
- DOI
- 10.1016/j.bmc.2007.02.038
- eISSN
- 1464-3391
- Externe Identifier
- PubMed Identifier: 17346977
- Open access
- false
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Bioorganic & medicinal chemistry
- Schlüsselwörter
- Neoplasms
- Fluorine Radioisotopes
- Choline
- Chromatography, High Pressure Liquid
- Sensitivity and Specificity
- Molecular Structure
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2007
- Paginierung
- 3171 - 3175
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum der Datenerfassung
- 2007
- Titel
- Improved automated synthesis of [18F]fluoroethylcholine as a radiotracer for cancer imaging.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Europe PubMed Central
- Abstract
- [(18)F]Fluoroethylcholine has been recently introduced as a promising (18)F-labelled analogue of [(11)C]choline which had been previously described as a tracer for metabolic cancer imaging with positron emission tomography (PET). Due to the practical advantages of using the longer-lived radioisotope (18)F (t(1/2)=110 min), offering the opportunity of a more widespread clinical application, we established a reliable, fully automated synthesis for its production using a modified, commercially available module. [(18)F]Fluoroethylcholine was prepared from N,N-dimethylaminoethanol by iodide catalyzed alkylation with 1-[(18)F]fluoro-2-tosylethane as alkylating agent, resulting in a total radiochemical yield of 30+/-6% after a synthesis time of 50 min. The specific activity of [(18)F]fluoroethylcholine was >55 GBq/micromol and the radiochemical purity 95-99%.
- Date of acceptance
- 2007
- Autoren
- M Piel
- A Bauman
- RP Baum
- S Höhnemann
- I Klette
- R Wortmann
- F Rösch
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17346977
- DOI
- 10.1016/j.bmc.2007.02.038
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Bioorg Med Chem
- Schlüsselwörter
- Choline
- Chromatography, High Pressure Liquid
- Fluorine Radioisotopes
- Molecular Structure
- Neoplasms
- Sensitivity and Specificity
- Sprache
- eng
- Country
- England
- Paginierung
- 3171 - 3175
- PII
- S0968-0896(07)00160-5
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2007
- Titel
- Improved automated synthesis of [18F]fluoroethylcholine as a radiotracer for cancer imaging.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 15
Datenquelle: PubMed
- Autoren
- M Piel
- A Bauman
- RP Baum
- S Höhnemann
- I Klette
- R Wortmann
- F Rösch
- Zeitschrift
- Bioorganic & medicinal chemistry
- Artikelnummer
- 9
- Paginierung
- 3171 - 3175
- Datum der Veröffentlichung
- 2007
- Herausgeber
- Pergamon
- Datum der Datenerfassung
- 2021
- Titel
- Improved automated synthesis of [18F] fluoroethylcholine as a radiotracer for cancer imaging
- Sub types
- article
- Ausgabe der Zeitschrift
- 15
Datenquelle: Manual
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