Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Florian Rosar
- Hans-Georg Buchholz
- Sebastian Michels
- Manuela A Hoffmann
- Markus Piel
- Christopher M Waldmann
- Frank Roesch
- Stefan Reuss
- Mathias Schreckenberger
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000519353000001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1186/s40658-020-0286-3
- Externe Identifier
- Clarivate Analytics Document Solution ID: KT9SH
- PubMed Identifier: 32166581
- ISSN
- 2197-7364
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- EJNMMI PHYSICS
- Schlüsselwörter
- Scandium-44
- Small animal PET
- Phantom study
- Resolution
- Image quality
- Positron energy
- Positron range
- Artikelnummer
- ARTN 16
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Image quality analysis of <SUP>44</SUP>Sc on two preclinical PET scanners: a comparison to <SUP>68</SUP>Ga
- Sub types
- Article
- Ausgabe der Zeitschrift
- 7
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p><jats:sup>44</jats:sup>Sc has been increasingly investigated as a potential alternative to <jats:sup>68</jats:sup>Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of <jats:sup>44</jats:sup>Sc (0.63 MeV) compared to <jats:sup>68</jats:sup>Ga (0.83 MeV) can result in better spatial image resolutions. However, high-energy γ-rays (1157 keV) are emitted at high rates (99.9%) during <jats:sup>44</jats:sup>Sc decay, which can reduce image quality. Therefore, we investigated the impact of these physical properties and performed an unbiased performance evaluation of <jats:sup>44</jats:sup>Sc and <jats:sup>68</jats:sup>Ga with different imaging phantoms (image quality phantom, Derenzo phantom, and three-rod phantom) on two preclinical PET scanners (Mediso nanoScan PET/MRI, Siemens microPET Focus 120).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Despite the presence of high-energy γ-rays in <jats:sup>44</jats:sup>Sc decay, a higher image resolution of small structures was observed with <jats:sup>44</jats:sup>Sc when compared to <jats:sup>68</jats:sup>Ga. Structures as small as 1.3 mm using the Mediso system, and as small as 1.0 mm using the Siemens system, could be visualized and analyzed by calculating full width at half maximum. Full widths at half maxima were similar for both isotopes. For image quality comparison, we calculated recovery coefficients in 1–5 mm rods and spillover ratios in either air, water, or bone-equivalent material (Teflon). Recovery coefficients for <jats:sup>44</jats:sup>Sc were significantly higher than those for <jats:sup>68</jats:sup>Ga. Despite the lower positron energy, <jats:sup>44</jats:sup>Sc-derived spillover ratio (SOR) values were similar or slightly higher to <jats:sup>68</jats:sup>Ga-derived SOR values. This may be attributed to the higher background caused by the additional γ-rays. On the Siemens system, an overestimation of scatter correction in the central part of the phantom was observed causing a virtual disappearance of spillover inside the three-rod phantom.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Based on these findings, <jats:sup>44</jats:sup>Sc appears to be a suitable alternative to <jats:sup>68</jats:sup>Ga. The superior image resolution makes it an especially strong competitor in preclinical settings. The additional γ-emissions have a small impact on the imaging resolution but cause higher background noises and can effect an overestimation of scatter correction, depending on the PET system and phantom.</jats:p> </jats:sec>
- Autoren
- Florian Rosar
- Hans-Georg Buchholz
- Sebastian Michels
- Manuela A Hoffmann
- Markus Piel
- Christopher M Waldmann
- Frank Rösch
- Stefan Reuss
- Mathias Schreckenberger
- DOI
- 10.1186/s40658-020-0286-3
- eISSN
- 2197-7364
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- EJNMMI Physics
- Sprache
- en
- Artikelnummer
- 16
- Online publication date
- 2020
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1186/s40658-020-0286-3
- Datum der Datenerfassung
- 2021
- Titel
- Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga
- Ausgabe der Zeitschrift
- 7
Datenquelle: Crossref
- Abstract
- <h4>Background</h4><sup>44</sup>Sc has been increasingly investigated as a potential alternative to <sup>68</sup>Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of <sup>44</sup>Sc (0.63 MeV) compared to <sup>68</sup>Ga (0.83 MeV) can result in better spatial image resolutions. However, high-energy γ-rays (1157 keV) are emitted at high rates (99.9%) during <sup>44</sup>Sc decay, which can reduce image quality. Therefore, we investigated the impact of these physical properties and performed an unbiased performance evaluation of <sup>44</sup>Sc and <sup>68</sup>Ga with different imaging phantoms (image quality phantom, Derenzo phantom, and three-rod phantom) on two preclinical PET scanners (Mediso nanoScan PET/MRI, Siemens microPET Focus 120).<h4>Results</h4>Despite the presence of high-energy γ-rays in <sup>44</sup>Sc decay, a higher image resolution of small structures was observed with <sup>44</sup>Sc when compared to <sup>68</sup>Ga. Structures as small as 1.3 mm using the Mediso system, and as small as 1.0 mm using the Siemens system, could be visualized and analyzed by calculating full width at half maximum. Full widths at half maxima were similar for both isotopes. For image quality comparison, we calculated recovery coefficients in 1-5 mm rods and spillover ratios in either air, water, or bone-equivalent material (Teflon). Recovery coefficients for <sup>44</sup>Sc were significantly higher than those for <sup>68</sup>Ga. Despite the lower positron energy, <sup>44</sup>Sc-derived spillover ratio (SOR) values were similar or slightly higher to <sup>68</sup>Ga-derived SOR values. This may be attributed to the higher background caused by the additional γ-rays. On the Siemens system, an overestimation of scatter correction in the central part of the phantom was observed causing a virtual disappearance of spillover inside the three-rod phantom.<h4>Conclusion</h4>Based on these findings, <sup>44</sup>Sc appears to be a suitable alternative to <sup>68</sup>Ga. The superior image resolution makes it an especially strong competitor in preclinical settings. The additional γ-emissions have a small impact on the imaging resolution but cause higher background noises and can effect an overestimation of scatter correction, depending on the PET system and phantom.
- Addresses
- Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. florian.rosar@uks.eu.
- Autoren
- Florian Rosar
- Hans-Georg Buchholz
- Sebastian Michels
- Manuela A Hoffmann
- Markus Piel
- Christopher M Waldmann
- Frank Rösch
- Stefan Reuss
- Mathias Schreckenberger
- DOI
- 10.1186/s40658-020-0286-3
- eISSN
- 2197-7364
- Externe Identifier
- PubMed Identifier: 32166581
- PubMed Central ID: PMC7067939
- Open access
- true
- ISSN
- 2197-7364
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- EJNMMI physics
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2020
- Open access status
- Open Access
- Paginierung
- 16
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2020
- Titel
- Image quality analysis of <sup>44</sup>Sc on two preclinical PET scanners: a comparison to <sup>68</sup>Ga.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 7
Files
https://ejnmmiphys.springeropen.com/track/pdf/10.1186/s40658-020-0286-3 https://europepmc.org/articles/PMC7067939?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- BACKGROUND: 44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga (0.83 MeV) can result in better spatial image resolutions. However, high-energy γ-rays (1157 keV) are emitted at high rates (99.9%) during 44Sc decay, which can reduce image quality. Therefore, we investigated the impact of these physical properties and performed an unbiased performance evaluation of 44Sc and 68Ga with different imaging phantoms (image quality phantom, Derenzo phantom, and three-rod phantom) on two preclinical PET scanners (Mediso nanoScan PET/MRI, Siemens microPET Focus 120). RESULTS: Despite the presence of high-energy γ-rays in 44Sc decay, a higher image resolution of small structures was observed with 44Sc when compared to 68Ga. Structures as small as 1.3 mm using the Mediso system, and as small as 1.0 mm using the Siemens system, could be visualized and analyzed by calculating full width at half maximum. Full widths at half maxima were similar for both isotopes. For image quality comparison, we calculated recovery coefficients in 1-5 mm rods and spillover ratios in either air, water, or bone-equivalent material (Teflon). Recovery coefficients for 44Sc were significantly higher than those for 68Ga. Despite the lower positron energy, 44Sc-derived spillover ratio (SOR) values were similar or slightly higher to 68Ga-derived SOR values. This may be attributed to the higher background caused by the additional γ-rays. On the Siemens system, an overestimation of scatter correction in the central part of the phantom was observed causing a virtual disappearance of spillover inside the three-rod phantom. CONCLUSION: Based on these findings, 44Sc appears to be a suitable alternative to 68Ga. The superior image resolution makes it an especially strong competitor in preclinical settings. The additional γ-emissions have a small impact on the imaging resolution but cause higher background noises and can effect an overestimation of scatter correction, depending on the PET system and phantom.
- Date of acceptance
- 2020
- Autoren
- Florian Rosar
- Hans-Georg Buchholz
- Sebastian Michels
- Manuela A Hoffmann
- Markus Piel
- Christopher M Waldmann
- Frank Rösch
- Stefan Reuss
- Mathias Schreckenberger
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/32166581
- DOI
- 10.1186/s40658-020-0286-3
- Externe Identifier
- PubMed Central ID: PMC7067939
- ISSN
- 2197-7364
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- EJNMMI Phys
- Schlüsselwörter
- Image quality
- Phantom study
- Positron energy
- Positron range
- Resolution
- Scandium-44
- Small animal PET
- Sprache
- eng
- Country
- Germany
- Paginierung
- 16
- PII
- 10.1186/s40658-020-0286-3
- Datum der Veröffentlichung
- 2020
- Status
- Published online
- Titel
- Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 7
Datenquelle: PubMed
- Beziehungen:
- Eigentum von