Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000557578600001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/biom10071000
eISSN
2218-273X
Externe Identifier
  • Clarivate Analytics Document Solution ID: MX2TA
  • PubMed Identifier: 32635587
Ausgabe der Veröffentlichung
7
Zeitschrift
BIOMOLECULES
Schlüsselwörter
  • green tea
  • catechins
  • chemotherapy
  • drug resistance
  • flavonoids
  • functional food
  • microarray analysis
  • natural products
  • polyphenols
Artikelnummer
ARTN 1000
Datum der Veröffentlichung
2020
Status
Published
Titel
Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells
Sub types
  • Article
Ausgabe der Zeitschrift
10

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects of its chemopreventive effect on hematological malignancies have not been defined. In the present study, we evaluated antitumor efficacies of a specific green tea, sencha tea, on sensitive and multidrug-resistant leukemia and a panel of nine multiple myelomas (MM) cell lines. We found that sencha extracts induced cytotoxicity in leukemic cells and MM cells to different extents, yet its effect on normal cells was limited. Furthermore, sencha extracts caused G2/M and G0/G1 phase arrest during cell cycle progression in CCRF/CEM and KMS-12-BM cells, respectively. Specifically, sencha-MeOH/H2O extracts induced apoptosis, ROS, and MMP collapse on both CCRF/CEM and KMS-12-BM cells. The analysis with microarray and COMPARE in 53 cell lines of the NCI panel revealed diverse functional groups, including cell morphology, cellular growth and proliferation, cell cycle, cell death, and survival, which were closely associated with anti-tumor effects of sencha tea. It is important to note that PI3K/Akt and NF-κB pathways were the top two dominant networks by ingenuity pathway analysis. We demonstrate here the multifactorial modes of action of sencha tea leading to chemopreventive effects of sencha tea against cancer.</jats:p>
Autoren
DOI
10.3390/biom10071000
eISSN
2218-273X
Ausgabe der Veröffentlichung
7
Zeitschrift
Biomolecules
Sprache
en
Online publication date
2020
Paginierung
1000 - 1000
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/biom10071000
Datum der Datenerfassung
2020
Titel
Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells
Ausgabe der Zeitschrift
10

Datenquelle: Crossref

Abstract
The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects of its chemopreventive effect on hematological malignancies have not been defined. In the present study, we evaluated antitumor efficacies of a specific green tea, sencha tea, on sensitive and multidrug-resistant leukemia and a panel of nine multiple myelomas (MM) cell lines. We found that sencha extracts induced cytotoxicity in leukemic cells and MM cells to different extents, yet its effect on normal cells was limited. Furthermore, sencha extracts caused G2/M and G0/G1 phase arrest during cell cycle progression in CCRF/CEM and KMS-12-BM cells, respectively. Specifically, sencha-MeOH/H<sub>2</sub>O extracts induced apoptosis, ROS, and MMP collapse on both CCRF/CEM and KMS-12-BM cells. The analysis with microarray and COMPARE in 53 cell lines of the NCI panel revealed diverse functional groups, including cell morphology, cellular growth and proliferation, cell cycle, cell death, and survival, which were closely associated with anti-tumor effects of sencha tea. It is important to note that PI3K/Akt and NF-κB pathways were the top two dominant networks by ingenuity pathway analysis. We demonstrate here the multifactorial modes of action of sencha tea leading to chemopreventive effects of sencha tea against cancer.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Autoren
DOI
10.3390/biom10071000
eISSN
2218-273X
Externe Identifier
  • PubMed Identifier: 32635587
  • PubMed Central ID: PMC7407630
Open access
true
ISSN
2218-273X
Ausgabe der Veröffentlichung
7
Zeitschrift
Biomolecules
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Leukemia
  • Multiple Myeloma
  • Reactive Oxygen Species
  • NF-kappa B
  • Plant Extracts
  • Antineoplastic Agents, Phytogenic
  • Drug Resistance, Multiple
  • Signal Transduction
  • Cell Cycle
  • Cell Proliferation
  • Cell Survival
  • Gene Expression Regulation, Neoplastic
  • Drug Resistance, Neoplasm
  • Tea
  • Proto-Oncogene Proteins c-akt
  • Membrane Potential, Mitochondrial
  • Phosphatidylinositol 3-Kinases
Sprache
eng
Medium
Electronic
Online publication date
2020
Open access status
Open Access
Paginierung
E1000
Datum der Veröffentlichung
2020
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2020
Titel
Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
10

Files

https://www.mdpi.com/2218-273X/10/7/1000/pdf?version=1594785787 https://europepmc.org/articles/PMC7407630?pdf=render

Datenquelle: Europe PubMed Central

Abstract
The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects of its chemopreventive effect on hematological malignancies have not been defined. In the present study, we evaluated antitumor efficacies of a specific green tea, sencha tea, on sensitive and multidrug-resistant leukemia and a panel of nine multiple myelomas (MM) cell lines. We found that sencha extracts induced cytotoxicity in leukemic cells and MM cells to different extents, yet its effect on normal cells was limited. Furthermore, sencha extracts caused G2/M and G0/G1 phase arrest during cell cycle progression in CCRF/CEM and KMS-12-BM cells, respectively. Specifically, sencha-MeOH/H2O extracts induced apoptosis, ROS, and MMP collapse on both CCRF/CEM and KMS-12-BM cells. The analysis with microarray and COMPARE in 53 cell lines of the NCI panel revealed diverse functional groups, including cell morphology, cellular growth and proliferation, cell cycle, cell death, and survival, which were closely associated with anti-tumor effects of sencha tea. It is important to note that PI3K/Akt and NF-κB pathways were the top two dominant networks by ingenuity pathway analysis. We demonstrate here the multifactorial modes of action of sencha tea leading to chemopreventive effects of sencha tea against cancer.
Date of acceptance
2020
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32635587
DOI
10.3390/biom10071000
eISSN
2218-273X
Externe Identifier
  • PubMed Central ID: PMC7407630
Ausgabe der Veröffentlichung
7
Zeitschrift
Biomolecules
Schlüsselwörter
  • catechins
  • chemotherapy
  • drug resistance
  • flavonoids
  • functional food
  • green tea
  • microarray analysis
  • natural products
  • polyphenols
  • Antineoplastic Agents, Phytogenic
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Leukemia
  • Membrane Potential, Mitochondrial
  • Multiple Myeloma
  • NF-kappa B
  • Phosphatidylinositol 3-Kinases
  • Plant Extracts
  • Proto-Oncogene Proteins c-akt
  • Reactive Oxygen Species
  • Signal Transduction
  • Tea
Sprache
eng
Country
Switzerland
PII
biom10071000
Datum der Veröffentlichung
2020
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
10

Datenquelle: PubMed

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