Author: Hellmich, Ute A / Organizational unit: FB 09 Chemie, Pharmazie, Geographie und Geowissenschaften and Pharmazeutische/Medizinische Chemie 1 / Data source: PubMed - Universitätsbibliographie Search Results

Start Over Author Hellmich, Ute A Organizational unit FB 09 Chemie, Pharmazie, Geographie und Geowissenschaften Organizational unit Pharmazeutische/Medizinische Chemie 1 Data source PubMed

1. Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense

Autoren:: Di Chio, Carla; Previti, Santo; Amendola, Giorgio; Ravichandran, Rahul; Wagner, Annika; Cosconati, Sandro; Hellmich, Ute A; Schirmeister, Tanja; Zappala, Maria; Ettari, Roberta
Veröffentlichungsdatum:: 2022
Type:: Journal article

2. New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins

Autoren:: Jung, Sascha; Fuchs, Natalie; Grathwol, Christoph; Hellmich, Ute A; Wagner, Annika; Diehl, Erika; Willmes, Thomas; Sotriffer, Christoph; Schirmeister, Tanja
Veröffentlichungsdatum:: 2022
Type:: Journal article

3. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs)

Autoren:: Previti, Santo; Ettari, Roberta; Cosconati, Sandro; Arnendola, Giorgio; Chouchene, Khawla; Wagner, Annika; Hellmich, Ute A; Ulrich, Kathrin; Krauth-Siegel, R Luise; Wich, Peter R; Schmid, Ira; Schirmeister, Tanja; Gut, Jiri; Rosenthal, Philip J; Grasso, Silvana; Zappala, Maria
Veröffentlichungsdatum:: 2017
Type:: Journal article

4. Optimization strategy of novel peptide-based Michael acceptors for the treatment of human African trypanosomiasis

Autoren:: Ettari, Roberta; Previti, Santo; Maiorana, Santina; Amendola, Giorgio; Wagner, Annika; Cosconati, Sandro; Schirmeister, Tanja; Hellmich, Ute A; Zappala, Maria
Veröffentlichungsdatum:: 2019
Type:: Journal article

5. Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment

Autoren:: Maiorana, Santina; Ettari, Roberta; Previti, Santo; Amendola, Giorgio; Wagner, Annika; Cosconati, Sandro; Hellmich, Ute A; Schirmeister, Tanja; Zappala, Maria
Veröffentlichungsdatum:: 2020
Type:: Journal article

6. The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and 19F NMR

Autoren:: Maus, Hannah; Hammerschmidt, Stefan J; Hinze, Gerald; Barthels, Fabian; Carrillo, Victor H Perez; Hellmich, Ute A; Basche, Thomas; Schirmeister, Tanja
Veröffentlichungsdatum:: 2023
Type:: Journal article

7. Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases

Autoren:: Millies, Benedikt; von Hammerstein, Franziska; Gellert, Andrea; Hammerschmidt, Stefan; Barthels, Fabian; Goeppel, Ulrike; Immerheiser, Melissa; Elgner, Fabian; Jung, Nathalie; Basic, Michael; Kersten, Christian; Kiefer, Werner; Bodem, Jochen; Hildt, Eberhard; Windbergs, Maike; Hellmich, Ute A; Schirmeister, Tanja
Veröffentlichungsdatum:: 2019
Type:: Journal article

8. Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain

Autoren:: Johe, Patrick; Jung, Sascha; Endres, Erik; Kersten, Christian; Zimmer, Collin; Ye, Weixiang; Soennichsen, Carsten; Hellmich, Ute A; Sotriffer, Christoph; Schirmeister, Tanja; Neuweiler, Hannes
Veröffentlichungsdatum:: 2021
Type:: Journal article

9. Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

Autoren:: Johe, Patrick; Jaenicke, Elmar; Neuweiler, Hannes; Schirmeister, Tanja; Kersten, Christian; Hellmich, Ute A
Veröffentlichungsdatum:: 2021
Type:: Journal article

10. Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

Autoren:: Jung, Sascha; Fuchs, Natalie; Johe, Patrick; Wagner, Annika; Diehl, Erika; Yuliani, Tri; Zimmer, Collin; Barthels, Fabian; Zimmermann, Robert A; Klein, Philipp; Waigel, Waldemar; Meyr, Jessica; Opatz, Till; Tenzer, Stefan; Distler, Ute; Raeder, Hans-Joachim; Kersten, Christian; Engels, Bernd; Hellmich, Ute A; Klein, Jochen; Schirmeister, Tanja
Veröffentlichungsdatum:: 2021
Type:: Journal article