Author: Engels, Bernd / Organizational unit: Institut für Pharmazeutische und Biomedizinische Wissenschaften and Pharmazeutische/Medizinische Chemie 1 / Data source: PubMed - Universitätsbibliographie Search Results

Start Over Author Engels, Bernd Organizational unit Institut für Pharmazeutische und Biomedizinische Wissenschaften Organizational unit Pharmazeutische/Medizinische Chemie 1 Data source PubMed

1. Evidence for Substrate Binding-Induced Zwitterion Formation in the Catalytic Cys-His Dyad of the SARS-CoV Main Protease

Autoren:: Paasche, Alexander; Zipper, Andreas; Schaefer, Simon; Ziebuhr, John; Schirmeister, Tanja; Engels, Bernd
Veröffentlichungsdatum:: 2014
Type:: Journal article

2. Rational Design of Improved Aziridine-Based Inhibitors of Cysteine Proteases

Autoren:: Buback, Verena; Mladenovic, Milena; Engels, Bernd; Schirmeister, Tanja
Veröffentlichungsdatum:: 2009
Type:: Journal article

3. Atomistic insights into the inhibition of cysteine proteases: First QM/MM calculations clarifying the stereoselectivity of epoxide-based inhibitors

Autoren:: Mladenovic, Milena; Ansorg, Kay; Fink, Reinhold F; Thiel, Walter; Schirmeister, Tanja; Engels, Bernd
Veröffentlichungsdatum:: 2008
Type:: Journal article

4. Atomistic insights into the inhibition of cysteine proteases: First QM/MM calculations clarifying the regiospecificity and the inhibition potency of epoxide- and aziridine-based inhibitors

Autoren:: Mladenovic, Milena; Junold, Konstantin; Fink, Reinhold F; Thiel, Walter; Schirmeister, Tanja; Engels, Bernd
Veröffentlichungsdatum:: 2008
Type:: Journal article

5. The importance of the active site histidine for the activity of epoxide- or aziridine-based inhibitors of cysteine proteases

Autoren:: Mladenovic, Milena; Schirmeister, Tanja; Thiel, Stefan; Thiel, Walter; Engels, Bernd
Veröffentlichungsdatum:: 2007
Type:: Journal article

6. Aziridide-based inhibitors of cathepsin L: Synthesis, inhibition activity, and docking studies

Autoren:: Vicik, Radim; Busemann, Matthias; Gelhaus, Christoph; Stiefl, Nikolaus; Scheiber, Josef; Schmitz, Werner; Schulz, Franziska; Mladenovic, Milena; Engels, Bernd; Leippe, Matthias; Baumann, Knut; Schirmeister, Tanja
Veröffentlichungsdatum:: 2006
Type:: Journal article

7. Rational design of aziridine-containing cysteine protease inhibitors with improved potency: Studies on inhibition mechanism

Autoren:: Vicik, Radim; Helten, Holger; Schirmeister, Tanja; Engels, Bernd
Veröffentlichungsdatum:: 2006
Type:: Journal article

8. Similarities and Differences between Crystal and Enzyme Environmental Effects on the Electron Density of Drug Molecules

Autoren:: Kleemiss, Florian; Wieduwilt, Erna K; Hupf, Emanuel; Shi, Ming W; Stewart, Scott G; Jayatilaka, Dylan; Turner, Michael J; Sugimoto, Kunihisa; Nishibori, Eiji; Schirmeister, Tanja; Schmidt, Thomas C; Engels, Bernd; Grabowsky, Simon
Veröffentlichungsdatum:: 2021
Type:: Journal article

9. On the origin of the stabilization of the zwitterionic resting state of cysteine proteases: A theoretical study

Autoren:: Mladenovic, Milena; Fink, Reinhold F; Thiel, Walter; Schirmeister, Tanja; Engels, Bernd
Veröffentlichungsdatum:: 2008
Type:: Journal article

10. Origin of the Reactivity Differences of Substituted Aziridines: CN vs CC Bond Breakages

Autoren:: Paasche, Alexander; Arnone, Mario; Fink, Reinhold F; Schirmeister, Tanja; Engels, Bernd
Veröffentlichungsdatum:: 2009
Type:: Journal article