Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Yaseen Hussain
- Haroon Khan
- Thomas Efferth
- Waqas Alam
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000795144100002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phymed.2022.153985
- eISSN
- 1618-095X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 1F4MZ
- PubMed Identifier: 35358935
- ISSN
- 0944-7113
- Zeitschrift
- PHYTOMEDICINE
- Schlüsselwörter
- Mode-of-action
- Phytochemicals
- Phytotherapy
- Signal transduction
- Artikelnummer
- ARTN 153985
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects
- Sub types
- Article
- Ausgabe der Zeitschrift
- 100
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Yaseen Hussain
- Haroon Khan
- Thomas Efferth
- Waqas Alam
- DOI
- 10.1016/j.phymed.2022.153985
- ISSN
- 0944-7113
- Zeitschrift
- Phytomedicine
- Sprache
- en
- Artikelnummer
- 153985
- Paginierung
- 153985 - 153985
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phymed.2022.153985
- Datum der Datenerfassung
- 2023
- Titel
- Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects
- Ausgabe der Zeitschrift
- 100
Data source: Crossref
- Abstract
- <h4>Background</h4>Cancer is still an all-times issue due to a large and even increasing number of deaths. Impaired genes regulating cell proliferation and apoptosis are targets for the development of novel cancer treatments.<h4>Hypothesis</h4>Increased transcription of NADPH oxidase activator (NOXA), Bcl2-like11 (BIM), BH3-only proteins and p53 unregulated apoptosis modulator (PUMA) is caused by the imbalance between pro- and anti-apoptotic Bcl-2 proteins due to endoplasmic reticulum (ER) stress. The membranous network of ER is present in all eukaryotic cells. ER stress facilitates the interaction between Bax and PUMA, triggering the release of cytochrome C. As a main intracellular organelle, ER is responsible for translocation as well as post-translation modification and protein folding.<h4>Results</h4>Hesperetin is a cytoprotective flavonone, which acts against ER stress and protects from cell damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Hesperetin inhibits lipid peroxidation induced by Fe<sup>2+</sup> and l-ascorbic acid in rat brain homogenates.<h4>Conclusion</h4>This review deals with the anticancer effects of hesperetin regarding the regulation of ER stress as a principal mechanism in the pathogenesis of tumors.
- Addresses
- College of Pharmaceutical Sciences, Soochow University, 215123, China.
- Autoren
- Yaseen Hussain
- Haroon Khan
- Thomas Efferth
- Waqas Alam
- DOI
- 10.1016/j.phymed.2022.153985
- eISSN
- 1618-095X
- Externe Identifier
- PubMed Identifier: 35358935
- Open access
- false
- ISSN
- 0944-7113
- Zeitschrift
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Schlüsselwörter
- Animals
- Rats
- Hesperidin
- Antineoplastic Agents, Phytogenic
- Apoptosis
- Apoptosis Regulatory Proteins
- Endoplasmic Reticulum Stress
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Paginierung
- 153985
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum der Datenerfassung
- 2022
- Titel
- Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 100
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Cancer is still an all-times issue due to a large and even increasing number of deaths. Impaired genes regulating cell proliferation and apoptosis are targets for the development of novel cancer treatments. HYPOTHESIS: Increased transcription of NADPH oxidase activator (NOXA), Bcl2-like11 (BIM), BH3-only proteins and p53 unregulated apoptosis modulator (PUMA) is caused by the imbalance between pro- and anti-apoptotic Bcl-2 proteins due to endoplasmic reticulum (ER) stress. The membranous network of ER is present in all eukaryotic cells. ER stress facilitates the interaction between Bax and PUMA, triggering the release of cytochrome C. As a main intracellular organelle, ER is responsible for translocation as well as post-translation modification and protein folding. RESULTS: Hesperetin is a cytoprotective flavonone, which acts against ER stress and protects from cell damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Hesperetin inhibits lipid peroxidation induced by Fe2+ and l-ascorbic acid in rat brain homogenates. CONCLUSION: This review deals with the anticancer effects of hesperetin regarding the regulation of ER stress as a principal mechanism in the pathogenesis of tumors.
- Date of acceptance
- 2022
- Autoren
- Yaseen Hussain
- Haroon Khan
- Thomas Efferth
- Waqas Alam
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35358935
- DOI
- 10.1016/j.phymed.2022.153985
- eISSN
- 1618-095X
- Zeitschrift
- Phytomedicine
- Schlüsselwörter
- Mode-of-action
- Phytochemicals
- Phytotherapy
- Signal transduction
- Animals
- Antineoplastic Agents, Phytogenic
- Apoptosis
- Apoptosis Regulatory Proteins
- Endoplasmic Reticulum Stress
- Hesperidin
- Rats
- Sprache
- eng
- Country
- Germany
- Paginierung
- 153985
- PII
- S0944-7113(22)00063-0
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 100
Data source: PubMed
- Beziehungen:
- Property of