Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Tarik A Mohamed
- Sherin K Ali
- Abdelsamed I Elshamy
- Ibrahim A Saleh
- Mahmoud AA Ibrahim
- Mohamed AM Atia
- Shifaa O Alshammari
- Abou El-Hamd H Mohamed
- Taha A Hussien
- Ahmed R Hamed
- Hesham R El Saedi
- Nahla S Abdel-Azim
- Khaled A Shams
- Thomas Efferth
- Mahmoud Saker
- Paul W Pare
- Mohamed-Elamir F Hegazy
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000795144100003&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phymed.2022.154019
- eISSN
- 1618-095X
- Externe Identifier
- Clarivate Analytics Document Solution ID: 1F4MZ
- PubMed Identifier: 35325826
- ISSN
- 0944-7113
- Zeitschrift
- PHYTOMEDICINE
- Schlüsselwörter
- Germany
- Polyphenolic
- Flavonoid
- Enzymatic biotransformation
- Plant cell cultures
- Pharmaceutical products
- Artikelnummer
- ARTN 154019
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations
- Sub types
- Article
- Ausgabe der Zeitschrift
- 100
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Tarik A Mohamed
- Sherin K Ali
- Abdelsamed I Elshamy
- Ibrahim A Saleh
- Mahmoud AA Ibrahim
- Mohamed AM Atia
- Shifaa O Alshammari
- Abou El-Hamd H Mohamed
- Taha A Hussien
- Ahmed R Hamed
- Hesham R El Saedi
- Nahla S Abdel-Azim
- Khaled A Shams
- Thomas Efferth
- Mahmoud Saker
- Paul W Paré
- Mohamed-Elamir F Hegazy
- DOI
- 10.1016/j.phymed.2022.154019
- ISSN
- 0944-7113
- Zeitschrift
- Phytomedicine
- Sprache
- en
- Artikelnummer
- 154019
- Paginierung
- 154019 - 154019
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phymed.2022.154019
- Datum der Datenerfassung
- 2023
- Titel
- Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations
- Ausgabe der Zeitschrift
- 100
Data source: Crossref
- Abstract
- <h4>Background</h4>In the pharmaceutical sector, tissue culture techniques for large-scale production of natural chemicals can be a less expensive alternative to large-scale synthesis. Although recent biotransformation research have used plant cell cultures to target a wide range of bioactive compounds, more compiled information and synopses are needed to better understand metabolic pathways and improve biotransformation efficiencies.<h4>Purpose</h4>This report reviews the biochemical transformation of phenolic natural products by plant cell cultures in order to identify potential novel biotechnological approaches for ensuring more homogeneous and stable phenolic production year-round under controlled environmental conditions.<h4>Methods</h4>Articles on the use of plant cell culture for polyphenolic and flavonoid transformations (1988 - 2021) were retrieved from SciFinder, PubMed, Scopus, and Web of Science through electronic and manual search in English. Following that, the authors chose the required papers based on the criteria they defined. The following keywords were used for the online search: biotransformation, Plant cell cultures, flavonoids, phenolics, and pharmaceutical products.<h4>Results</h4>The initial search found a total of 96 articles. However, only 70 of them were selected as they met the inclusion criteria defined by the authors. The analysis of these studies revealed that plant tissue culture is applicable for the large-scale production of plant secondary metabolites including the phenolics, which have high therapeutic value.<h4>Conclusion</h4>Plant tissue cultures could be employed as an efficient technique for producing secondary metabolites including phenolics. Phenolics possess a wide range of therapeutic benefits, as anti-oxidant, anti-cancer, and anti-inflammatory properties. Callus culture, suspension cultures, transformation, and other procedures have been used to improve the synthesis of phenolics. Their production on a large scale is now achievable. More breakthroughs will lead to newer insights and, without a doubt, to a new era of phenolics-based pharmacological agents for the treatment of a variety of infectious and degenerative disorders.
- Addresses
- Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
- Autoren
- Tarik A Mohamed
- Sherin K Ali
- Abdelsamed I Elshamy
- Ibrahim A Saleh
- Mahmoud AA Ibrahim
- Mohamed AM Atia
- Shifaa O Alshammari
- Abou El-Hamd H Mohamed
- Taha A Hussien
- Ahmed R Hamed
- Hesham R El Saedi
- Nahla S Abdel-Azim
- Khaled A Shams
- Thomas Efferth
- Mahmoud Saker
- Paul W Paré
- Mohamed-Elamir F Hegazy
- DOI
- 10.1016/j.phymed.2022.154019
- eISSN
- 1618-095X
- Externe Identifier
- PubMed Identifier: 35325826
- Open access
- false
- ISSN
- 0944-7113
- Zeitschrift
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Schlüsselwörter
- Plants
- Phenols
- Flavonoids
- Antioxidants
- Cell Culture Techniques
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Paginierung
- 154019
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum der Datenerfassung
- 2022
- Titel
- Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 100
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: In the pharmaceutical sector, tissue culture techniques for large-scale production of natural chemicals can be a less expensive alternative to large-scale synthesis. Although recent biotransformation research have used plant cell cultures to target a wide range of bioactive compounds, more compiled information and synopses are needed to better understand metabolic pathways and improve biotransformation efficiencies. PURPOSE: This report reviews the biochemical transformation of phenolic natural products by plant cell cultures in order to identify potential novel biotechnological approaches for ensuring more homogeneous and stable phenolic production year-round under controlled environmental conditions. METHODS: Articles on the use of plant cell culture for polyphenolic and flavonoid transformations (1988 - 2021) were retrieved from SciFinder, PubMed, Scopus, and Web of Science through electronic and manual search in English. Following that, the authors chose the required papers based on the criteria they defined. The following keywords were used for the online search: biotransformation, Plant cell cultures, flavonoids, phenolics, and pharmaceutical products. RESULTS: The initial search found a total of 96 articles. However, only 70 of them were selected as they met the inclusion criteria defined by the authors. The analysis of these studies revealed that plant tissue culture is applicable for the large-scale production of plant secondary metabolites including the phenolics, which have high therapeutic value. CONCLUSION: Plant tissue cultures could be employed as an efficient technique for producing secondary metabolites including phenolics. Phenolics possess a wide range of therapeutic benefits, as anti-oxidant, anti-cancer, and anti-inflammatory properties. Callus culture, suspension cultures, transformation, and other procedures have been used to improve the synthesis of phenolics. Their production on a large scale is now achievable. More breakthroughs will lead to newer insights and, without a doubt, to a new era of phenolics-based pharmacological agents for the treatment of a variety of infectious and degenerative disorders.
- Date of acceptance
- 2022
- Autoren
- Tarik A Mohamed
- Sherin K Ali
- Abdelsamed I Elshamy
- Ibrahim A Saleh
- Mahmoud AA Ibrahim
- Mohamed AM Atia
- Shifaa O Alshammari
- Abou El-Hamd H Mohamed
- Taha A Hussien
- Ahmed R Hamed
- Hesham R El Saedi
- Nahla S Abdel-Azim
- Khaled A Shams
- Thomas Efferth
- Mahmoud Saker
- Paul W Paré
- Mohamed-Elamir F Hegazy
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35325826
- DOI
- 10.1016/j.phymed.2022.154019
- eISSN
- 1618-095X
- Zeitschrift
- Phytomedicine
- Schlüsselwörter
- Enzymatic biotransformation
- Flavonoid
- Pharmaceutical products
- Plant cell cultures
- Polyphenolic
- Antioxidants
- Cell Culture Techniques
- Flavonoids
- Phenols
- Plants
- Sprache
- eng
- Country
- Germany
- Paginierung
- 154019
- PII
- S0944-7113(22)00097-6
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Plant cell cultures: An enzymatic tool for polyphenolic and flavonoid transformations.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 100
Data source: PubMed
- Beziehungen:
- Property of