Chromatographically separable rotamers of an unhindered amide
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Mario Geffe
- Lars Andernach
- Oliver Trapp
- Till Opatz
- Sammlungen
- metadata
- ISSN
- 1860-5397
- Zeitschrift
- Beilstein journal of organic chemistry
- Schlüsselwörter
- 540 Chemie
- 540 Chemistry and allied sciences
- Sprache
- eng
- Paginierung
- Seiten: 701 - 706
- Datum der Veröffentlichung
- 2014
- Herausgeber
- Beilstein-Institut zur Förderung der Chemischen Wissenschaften
- Herausgeber URL
- http://dx.doi.org/10.3762/bjoc.10.63
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Chromatographically separable rotamers of an unhindered amide
- Ausgabe der Zeitschrift
- 10
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Autoren
- Mario Geffe
- Lars Andernach
- Oliver Trapp
- Till Opatz
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000333306800001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3762/bjoc.10.63
- Externe Identifier
- Clarivate Analytics Document Solution ID: AD5PZ
- PubMed Identifier: 24778722
- ISSN
- 1860-5397
- Zeitschrift
- BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
- Schlüsselwörter
- amides
- density functional calculations
- dynamic HPLC
- rotamers
- thermodynamics
- Paginierung
- 701 - 706
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Titel
- Chromatographically separable rotamers of an unhindered amide
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: Web of Science (Lite)
- Abstract
- <jats:p>Surprisingly stable formamide rotamers were encountered in the tetrahydroisoquinoline and morphinan series of alkaloids. We investigated the hindered rotation around the amide bond by dynamic high-performance liquid chromatography (DHPLC) and kinetic measurements of the interconversion of the rotamers which can readily be separated by HPLC as well as TLC. The experimental results of the different methods were compared to each other as well as to results obtained by DFT calculations.</jats:p>
- Date of acceptance
- 2014
- Autoren
- Mario Geffe
- Lars Andernach
- Oliver Trapp
- Till Opatz
- DOI
- 10.3762/bjoc.10.63
- eISSN
- 1860-5397
- Zeitschrift
- Beilstein Journal of Organic Chemistry
- Sprache
- en
- Online publication date
- 2014
- Paginierung
- 701 - 706
- Status
- Published online
- Herausgeber
- Beilstein Institut
- Herausgeber URL
- http://dx.doi.org/10.3762/bjoc.10.63
- Datum der Datenerfassung
- 2021
- Titel
- Chromatographically separable rotamers of an unhindered amide
- Ausgabe der Zeitschrift
- 10
Datenquelle: Crossref
- Abstract
- Surprisingly stable formamide rotamers were encountered in the tetrahydroisoquinoline and morphinan series of alkaloids. We investigated the hindered rotation around the amide bond by dynamic high-performance liquid chromatography (DHPLC) and kinetic measurements of the interconversion of the rotamers which can readily be separated by HPLC as well as TLC. The experimental results of the different methods were compared to each other as well as to results obtained by DFT calculations.
- Addresses
- Institut für Organische Chemie, Johannes Gutenberg Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
- Autoren
- Mario Geffe
- Lars Andernach
- Oliver Trapp
- Till Opatz
- DOI
- 10.3762/bjoc.10.63
- eISSN
- 1860-5397
- Externe Identifier
- PubMed Identifier: 24778722
- PubMed Central ID: PMC3999880
- Open access
- true
- ISSN
- 1860-5397
- Zeitschrift
- Beilstein journal of organic chemistry
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2014
- Open access status
- Open Access
- Paginierung
- 701 - 706
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2014
- Titel
- Chromatographically separable rotamers of an unhindered amide.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-10-63.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24778722/pdf/?tool=EBI https://europepmc.org/articles/PMC3999880?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Surprisingly stable formamide rotamers were encountered in the tetrahydroisoquinoline and morphinan series of alkaloids. We investigated the hindered rotation around the amide bond by dynamic high-performance liquid chromatography (DHPLC) and kinetic measurements of the interconversion of the rotamers which can readily be separated by HPLC as well as TLC. The experimental results of the different methods were compared to each other as well as to results obtained by DFT calculations.
- Date of acceptance
- 2014
- Autoren
- Mario Geffe
- Lars Andernach
- Oliver Trapp
- Till Opatz
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/24778722
- DOI
- 10.3762/bjoc.10.63
- Externe Identifier
- PubMed Central ID: PMC3999880
- ISSN
- 1860-5397
- Zeitschrift
- Beilstein J Org Chem
- Schlüsselwörter
- amides
- density functional calculations
- dynamic HPLC
- rotamers
- thermodynamics
- Sprache
- eng
- Country
- Germany
- Paginierung
- 701 - 706
- Datum der Veröffentlichung
- 2014
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Chromatographically separable rotamers of an unhindered amide.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: PubMed
- Beziehungen:
- Eigentum von