Total synthesis and biological evaluation of the natural product (−)-cyclonerodiol, a new inhibitor of IL-4 signaling
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Jens Langhanki
- Kristina Rudolph
- Gerhard Erkelb
- Till Opatz
- Sammlungen
- metadata
- ISSN
- 1477-0539
- Ausgabe der Veröffentlichung
- 47
- Zeitschrift
- Organic & biomolecular chemistry
- Schlüsselwörter
- 540 Chemie
- 540 Chemistry and allied sciences
- Sprache
- eng
- Paginierung
- Seiten: 9707 - 9715
- Datum der Veröffentlichung
- 2014
- Herausgeber
- RSC
- Herausgeber URL
- http://dx.doi.org/10.1039/C4OB02021A
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- Total synthesis and biological evaluation of the natural product (−)-cyclonerodiol, a new inhibitor of IL-4 signaling
- Ausgabe der Zeitschrift
- 12
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Autoren
- Jens Langhanki
- Kristina Rudolph
- Gerhard Erkel
- Till Opatz
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000345066100027&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1039/c4ob02021a
- eISSN
- 1477-0539
- Externe Identifier
- Clarivate Analytics Document Solution ID: AT6RK
- PubMed Identifier: 25350537
- ISSN
- 1477-0520
- Ausgabe der Veröffentlichung
- 47
- Zeitschrift
- ORGANIC & BIOMOLECULAR CHEMISTRY
- Paginierung
- 9707 - 9715
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Titel
- Total synthesis and biological evaluation of the natural product (-)-cyclonerodiol, a new inhibitor of IL-4 signaling
- Sub types
- Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: Web of Science (Lite)
- Abstract
- <p>The sesquiterpene (−)-cyclonerodiol is a specific inhibitor of IL-4 induced STAT6 signaling and is readily available from (−)-linalool.</p>
- Autoren
- Jens Langhanki
- Kristina Rudolph
- Gerhard Erkel
- Till Opatz
- DOI
- 10.1039/c4ob02021a
- eISSN
- 1477-0539
- ISSN
- 1477-0520
- Ausgabe der Veröffentlichung
- 47
- Zeitschrift
- Org. Biomol. Chem.
- Sprache
- en
- Online publication date
- 2014
- Paginierung
- 9707 - 9715
- Status
- Published online
- Herausgeber
- Royal Society of Chemistry (RSC)
- Herausgeber URL
- http://dx.doi.org/10.1039/c4ob02021a
- Datum der Datenerfassung
- 2024
- Titel
- Total synthesis and biological evaluation of the natural product (−)-cyclonerodiol, a new inhibitor of IL-4 signaling
- Ausgabe der Zeitschrift
- 12
Datenquelle: Crossref
- Abstract
- In a screening program of natural compounds from fungi, the known cyclopentanoid sesquiterpene (-)-cyclonerodiol was identified as a specific inhibitor of the IL-4 induced STAT6 signaling pathway (IC50 = 9.7 μM) which is required for the differentiation of naive CD4 T cells to T helper type 2 (Th2) lymphocytes. As many allergic conditions, including allergic asthma and atopic diseases, are driven by an excessive Th2 response, STAT6 is a promising target for the development of new therapeutics. The compound was synthesized in six steps from (-)-linalool using an epoxide radical cyclization as the key step.
- Addresses
- Institute of Organic Chemistry, University of Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. opatz@uni-mainz.de.
- Autoren
- Jens Langhanki
- Kristina Rudolph
- Gerhard Erkel
- Till Opatz
- DOI
- 10.1039/c4ob02021a
- eISSN
- 1477-0539
- Externe Identifier
- PubMed Identifier: 25350537
- Open access
- false
- ISSN
- 1477-0520
- Ausgabe der Veröffentlichung
- 47
- Zeitschrift
- Organic & biomolecular chemistry
- Schlüsselwörter
- Cell Line
- Humans
- Asthma
- Monoterpenes
- Sesquiterpenes
- Anti-Allergic Agents
- Interleukin-4
- Signal Transduction
- Cyclization
- STAT6 Transcription Factor
- Acyclic Monoterpenes
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2014
- Paginierung
- 9707 - 9715
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Datum der Datenerfassung
- 2014
- Titel
- Total synthesis and biological evaluation of the natural product (-)-cyclonerodiol, a new inhibitor of IL-4 signaling.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: Europe PubMed Central
- Abstract
- In a screening program of natural compounds from fungi, the known cyclopentanoid sesquiterpene (-)-cyclonerodiol was identified as a specific inhibitor of the IL-4 induced STAT6 signaling pathway (IC50 = 9.7 μM) which is required for the differentiation of naive CD4 T cells to T helper type 2 (Th2) lymphocytes. As many allergic conditions, including allergic asthma and atopic diseases, are driven by an excessive Th2 response, STAT6 is a promising target for the development of new therapeutics. The compound was synthesized in six steps from (-)-linalool using an epoxide radical cyclization as the key step.
- Autoren
- Jens Langhanki
- Kristina Rudolph
- Gerhard Erkel
- Till Opatz
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/25350537
- DOI
- 10.1039/c4ob02021a
- eISSN
- 1477-0539
- Ausgabe der Veröffentlichung
- 47
- Zeitschrift
- Org Biomol Chem
- Schlüsselwörter
- Acyclic Monoterpenes
- Anti-Allergic Agents
- Asthma
- Cell Line
- Cyclization
- Humans
- Interleukin-4
- Monoterpenes
- STAT6 Transcription Factor
- Sesquiterpenes
- Signal Transduction
- Sprache
- eng
- Country
- England
- Paginierung
- 9707 - 9715
- Datum der Veröffentlichung
- 2014
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2015
- Titel
- Total synthesis and biological evaluation of the natural product (-)-cyclonerodiol, a new inhibitor of IL-4 signaling.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 12
Datenquelle: PubMed
- Beziehungen:
- Eigentum von