Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • S Ehehalt
  • R Schweizer
  • G Blumenstock
  • C Pfaff
  • N Schurr
  • K Weber
  • MB Ranke
  • G Binder
  • Perikles Simon
Sammlungen
  • metadata
ISSN
0947-7349
Ausgabe der Veröffentlichung
4
Zeitschrift
Experimental and clinical endocrinology & diabetes
Schlüsselwörter
  • 796 Sport
  • 796 Athletic and outdoor sports and games
Sprache
eng
Paginierung
Seiten: 238 - 242
Datum der Veröffentlichung
2011
Herausgeber
Thieme
Herausgeber URL
http://dx.doi.org/10.1055/s-0030-1267964
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children
Ausgabe der Zeitschrift
119

Datenquelle: METADATA.UB

Andere Metadatenquellen:
Autoren
  • S Ehehalt
  • R Schweizer
  • G Blumenstock
  • C Pfaff
  • N Schurr
  • K Weber
  • MB Ranke
  • G Binder
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000290740800009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1055/s-0030-1267964
eISSN
1439-3646
Externe Identifier
  • Clarivate Analytics Document Solution ID: 765WT
  • PubMed Identifier: 21104587
ISSN
0947-7349
Ausgabe der Veröffentlichung
4
Zeitschrift
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Schlüsselwörter
  • myostatin
  • childhood obesity
  • intervention study
  • body composition
Paginierung
238 - 242
Datum der Veröffentlichung
2011
Status
Published
Titel
Investigation of Myostatin Serum Levels Before and After a 6-Month Lifestyle Intervention Program in Obese Children
Sub types
  • Article
Ausgabe der Zeitschrift
119

Datenquelle: Web of Science (Lite)

Abstract
<h4>Objective</h4>To investigate the relationship between myostatin serum levels and muscle mass, fat mass and HOMA before and after a 6-month lifestyle intervention program in obese children and adolescents.<h4>Design</h4>A total of 57 overweight children and adolescents (female, n=27; age range, 6.0-16.1 years) were examined between 2007 and 2009. Mean BMI (±SD) was 31.1 (5.7) kg/m(2) corresponding to a mean BMI-SDS LMS of 2.2 (0.4). Muscle and fat mass were determined by means of DXA. Serum myostatin was measured by using a competitive ELISA. RESULTS [MEAN±SD]: After the 6-month intervention program, muscle mass (+2.1±2.7 kg, p<0.0001), and percentage myostatin serum levels (+23.7±26.7%, p<0.0001) were higher than before, whereas decreases in BMI (-0.4 kg/m(2)±1.5, p<0.0001), fat mass (-1.2±3.9 kg, p<0.0001), and HOMA insulin sensitivity index (-0.78±3.28 SD, p=0.0004) were observed. In 86% (n=49, p<0.0001) of all cases, the intervention program resulted in a higher level of myostatin. After lifestyle intervention, patients with the greatest increase of myostatin had a significantly lower increase of muscle mass (p=0.048) but did not differ for fat mass. There was no significant correlation between Myostatin and HOMA insulin sensitivity index before and after lifestyle intervention.<h4>Conclusion</h4>Both muscle mass and serum myostatin increased concordantly. Patients with the greatest rise of myostatin had a significantly lower increase of muscle mass suggesting a negative feedback loop between myostatin and muscle tissue. In our study, the change of myostatin serum levels was not associated with the amount of fat mass or HOMA insulin sensitivity index.
Addresses
  • University Children's Hospital Tuebingen, Paediatric Endocrinology and Diabetes, Germany.
Autoren
  • S Ehehalt
  • R Schweizer
  • G Blumenstock
  • C Pfaff
  • N Schurr
  • K Weber
  • MB Ranke
  • G Binder
  • DISKUS-Study Group
DOI
10.1055/s-0030-1267964
eISSN
1439-3646
Externe Identifier
  • PubMed Identifier: 21104587
Open access
false
ISSN
0947-7349
Ausgabe der Veröffentlichung
4
Zeitschrift
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Schlüsselwörter
  • DISKUS-Study Group
  • Humans
  • Obesity
  • Retrospective Studies
  • Risk Reduction Behavior
  • Life Style
  • Time Factors
  • Adolescent
  • Child
  • Female
  • Male
  • Myostatin
Sprache
eng
Medium
Print-Electronic
Online publication date
2010
Paginierung
238 - 242
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2010
Titel
Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
119

Datenquelle: Europe PubMed Central

Abstract
OBJECTIVE: To investigate the relationship between myostatin serum levels and muscle mass, fat mass and HOMA before and after a 6-month lifestyle intervention program in obese children and adolescents. DESIGN: A total of 57 overweight children and adolescents (female, n=27; age range, 6.0-16.1 years) were examined between 2007 and 2009. Mean BMI (±SD) was 31.1 (5.7) kg/m(2) corresponding to a mean BMI-SDS LMS of 2.2 (0.4). Muscle and fat mass were determined by means of DXA. Serum myostatin was measured by using a competitive ELISA. RESULTS [MEAN±SD]: After the 6-month intervention program, muscle mass (+2.1±2.7 kg, p<0.0001), and percentage myostatin serum levels (+23.7±26.7%, p<0.0001) were higher than before, whereas decreases in BMI (-0.4 kg/m(2)±1.5, p<0.0001), fat mass (-1.2±3.9 kg, p<0.0001), and HOMA insulin sensitivity index (-0.78±3.28 SD, p=0.0004) were observed. In 86% (n=49, p<0.0001) of all cases, the intervention program resulted in a higher level of myostatin. After lifestyle intervention, patients with the greatest increase of myostatin had a significantly lower increase of muscle mass (p=0.048) but did not differ for fat mass. There was no significant correlation between Myostatin and HOMA insulin sensitivity index before and after lifestyle intervention. CONCLUSION: Both muscle mass and serum myostatin increased concordantly. Patients with the greatest rise of myostatin had a significantly lower increase of muscle mass suggesting a negative feedback loop between myostatin and muscle tissue. In our study, the change of myostatin serum levels was not associated with the amount of fat mass or HOMA insulin sensitivity index.
Autoren
  • S Ehehalt
  • R Schweizer
  • G Blumenstock
  • C Pfaff
  • N Schurr
  • K Weber
  • MB Ranke
  • G Binder
  • DISKUS-Study Group
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21104587
DOI
10.1055/s-0030-1267964
eISSN
1439-3646
Ausgabe der Veröffentlichung
4
Zeitschrift
Exp Clin Endocrinol Diabetes
Schlüsselwörter
  • Adolescent
  • Child
  • Female
  • Humans
  • Life Style
  • Male
  • Myostatin
  • Obesity
  • Retrospective Studies
  • Risk Reduction Behavior
  • Time Factors
Sprache
eng
Country
Germany
Paginierung
238 - 242
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
119

Datenquelle: PubMed

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