Altered expression of akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Sandra Waalkes
  • Perikles Simon
  • Jorg Hennenlotter
  • Judith Knapp
  • Hossein Tezval
  • Jurgen Serth
  • Arnulf Stenzl
  • Markus A Kuczyk
  • Axel S Merseburger
Sammlungen
  • metadata
ISSN
1021-335X
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncology reports
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Paginierung
Seiten: 1257 - 1260
Datum der Veröffentlichung
2010
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Altered expression of akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue
Ausgabe der Zeitschrift
23

Datenquelle: METADATA.UB

Andere Metadatenquellen:
Autoren
  • Sandra Waalkes
  • Perikles Simon
  • Joerg Hennenlotter
  • Judith Knapp
  • Hossein Tezval
  • Juergen Serth
  • Arnulf Stenzl
  • Markus A Kuczyk
  • Axel S Merseburger
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000277075100010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3892/or_00000758
eISSN
1791-2431
Externe Identifier
  • Clarivate Analytics Document Solution ID: 588MR
  • PubMed Identifier: 20372838
ISSN
1021-335X
Ausgabe der Veröffentlichung
5
Zeitschrift
ONCOLOGY REPORTS
Schlüsselwörter
  • prostate cancer
  • needle biopsies
  • PTEN
  • p-Akt
  • p27(kipl)
Paginierung
1257 - 1260
Datum der Veröffentlichung
2010
Status
Published
Titel
Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue
Sub types
  • Article
Ausgabe der Zeitschrift
23

Datenquelle: Web of Science (Lite)

Autoren
  • Merseburger
DOI
10.3892/or_00000758
eISSN
1791-2431
ISSN
1021-335X
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncology Reports
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
Spandidos Publications
Herausgeber URL
http://dx.doi.org/10.3892/or_00000758
Datum der Datenerfassung
2017
Titel
Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue
Ausgabe der Zeitschrift
23

Datenquelle: Crossref

Abstract
PTEN, p-Akt and p27kip1 are known to be altered in prostate cancer. The aim of the present study was to determine the addition of molecular markers to a classical histopathological approach to enhance the sensitivity in detection of malignant or premalignant lesions within prostatic biopsies. Forty-two fine needle biopsies from malignant, tumor adjacent and benign areas were obtained from 14 patients scheduled for a prostatic biopsy. Biomarker expression was determined by immunohistochemistry and correlated to different localizations. We observed a reduction of Akt signaling proteins in cancer tissue compared to benign controls with significantly lower expression of p27kip1 (P=0.0024), PTEN (P=0.0045) and p-Akt (P=0.028). A pathologist histopathologically classified the tumor adjacent tissue obtained from areas distinctly apart from the primary tumor as benign in all cases. In these regions we observed an intermediate expression of Akt signaling proteins without significant difference in relation to the findings in the malignant samples. The expression of Akt signaling proteins is reduced in prostate cancer compared to normal prostate tissue. The intermediate expression of these proteins in tumor adjacent tissue warrants further investigations into the role of Akt signaling in the carcinogenesis and early detection of prostate cancer. There seems to be a marked difference between the molecular and histopathological characterization of prostate tissue. Molecular markers might further augment the histopathological diagnosis suggesting the need for earlier repeated prostate biopsy in case of microscopic malignancy.
Addresses
  • Department of Urology, Hannover University Medical School, Hannover, Germany.
Autoren
  • Sandra Waalkes
  • Perikles Simon
  • Jörg Hennenlotter
  • Judith Knapp
  • Hossein Tezval
  • Jürgen Serth
  • Arnulf Stenzl
  • Markus A Kuczyk
  • Axel S Merseburger
DOI
10.3892/or_00000758
eISSN
1791-2431
Externe Identifier
  • PubMed Identifier: 20372838
Open access
false
ISSN
1021-335X
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncology reports
Schlüsselwörter
  • Prostate
  • Humans
  • Prostatic Neoplasms
  • Intracellular Signaling Peptides and Proteins
  • Biopsy, Needle
  • Immunohistochemistry
  • Chi-Square Distribution
  • Signal Transduction
  • Down-Regulation
  • Phosphorylation
  • Aged
  • Middle Aged
  • Male
  • Cyclin-Dependent Kinase Inhibitor p27
  • Proto-Oncogene Proteins c-akt
  • PTEN Phosphohydrolase
  • Biomarkers, Tumor
Sprache
eng
Medium
Print
Paginierung
1257 - 1260
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
23

Datenquelle: Europe PubMed Central

Abstract
PTEN, p-Akt and p27kip1 are known to be altered in prostate cancer. The aim of the present study was to determine the addition of molecular markers to a classical histopathological approach to enhance the sensitivity in detection of malignant or premalignant lesions within prostatic biopsies. Forty-two fine needle biopsies from malignant, tumor adjacent and benign areas were obtained from 14 patients scheduled for a prostatic biopsy. Biomarker expression was determined by immunohistochemistry and correlated to different localizations. We observed a reduction of Akt signaling proteins in cancer tissue compared to benign controls with significantly lower expression of p27kip1 (P=0.0024), PTEN (P=0.0045) and p-Akt (P=0.028). A pathologist histopathologically classified the tumor adjacent tissue obtained from areas distinctly apart from the primary tumor as benign in all cases. In these regions we observed an intermediate expression of Akt signaling proteins without significant difference in relation to the findings in the malignant samples. The expression of Akt signaling proteins is reduced in prostate cancer compared to normal prostate tissue. The intermediate expression of these proteins in tumor adjacent tissue warrants further investigations into the role of Akt signaling in the carcinogenesis and early detection of prostate cancer. There seems to be a marked difference between the molecular and histopathological characterization of prostate tissue. Molecular markers might further augment the histopathological diagnosis suggesting the need for earlier repeated prostate biopsy in case of microscopic malignancy.
Autoren
  • Sandra Waalkes
  • Perikles Simon
  • Jörg Hennenlotter
  • Judith Knapp
  • Hossein Tezval
  • Jürgen Serth
  • Arnulf Stenzl
  • Markus A Kuczyk
  • Axel S Merseburger
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20372838
DOI
10.3892/or_00000758
eISSN
1791-2431
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncol Rep
Schlüsselwörter
  • Aged
  • Biomarkers, Tumor
  • Biopsy, Needle
  • Chi-Square Distribution
  • Cyclin-Dependent Kinase Inhibitor p27
  • Down-Regulation
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Middle Aged
  • PTEN Phosphohydrolase
  • Phosphorylation
  • Prostate
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction
Sprache
eng
Country
Greece
Paginierung
1257 - 1260
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
23

Datenquelle: PubMed

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