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Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis : evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence

Publikationstyp:

Zeitschriftenaufsatz

Metadaten:

Autoren

Fabian Springer
Huu Phuc Nguyen
Jurgen Machann
Roland Schweizer
Michael B Ranke
Gerhard Binder
Fritz Schick
Stefan Ehehalt
Perikles Simon

Sammlungen

metadata

ISSN

1663-2826

Ausgabe der Veröffentlichung

Zeitschrift

Hormone research in paediatrics

Schlüsselwörter

796 Sport
796 Athletic and outdoor sports and games

Sprache

eng

Paginierung

Seiten: 376 - 380

Datum der Veröffentlichung

2010

Herausgeber URL

http://dx.doi.org/10.1159/000319707

Datum der Datenerfassung

2020

Datum, an dem der Datensatz öffentlich gemacht wurde

2020

Zugang

Public

Titel

Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis : evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence

Ausgabe der Zeitschrift

Datenquelle: METADATA.UB

Andere Metadatenquellen:

Autoren

Fabian Springer
Huu Phuc Nguyen
Juergen Machann
Roland Schweizer
Michael B Ranke
Gerhard Binder
Fritz Schick
Stefan Ehehalt

Autoren-URL

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000283859800011&DestLinkType=FullRecord&DestApp=WOS_CPL

DOI

10.1159/000319707

eISSN

1663-2826

Externe Identifier

Clarivate Analytics Document Solution ID: 675TT
PubMed Identifier: 20847546

ISSN

1663-2818

Ausgabe der Veröffentlichung

Zeitschrift

HORMONE RESEARCH IN PAEDIATRICS

Schlüsselwörter

Acanthosis nigricans
Children
Hepatic steatosis
Insulin resistance
Magnetic resonance imaging
Magnetic resonance spectroscopy

Paginierung

376 - 380

Datum der Veröffentlichung

2010

Status

Published

Titel

Normal-Weight 14-Year-Old Girl with Acanthosis Nigricans and Markedly Increased Hepatic Steatosis: Evidence for the Important Role of Ectopic Fat Deposition in the Pathogenesis of Insulin Resistance in Childhood and Adolescence

Sub types

Article

Ausgabe der Zeitschrift

Datenquelle: Web of Science (Lite)

Abstract

<i>Background:</i> A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. <i>Aim:</i> To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention. <i>Methods:</i> Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. <i>Results:</i> We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. <i>Conclusion:</i> This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.

Autoren

Fabian Springer
Huu Phuc Nguyen
Jürgen Machann
Roland Schweizer
Michael B Ranke
Gerhard Binder
Fritz Schick
Stefan Ehehalt

DOI

10.1159/000319707

eISSN

1663-2826

ISSN

1663-2818

Ausgabe der Veröffentlichung

Zeitschrift

Hormone Research in Paediatrics

Sprache

Online publication date

2010

Paginierung

376 - 380

Datum der Veröffentlichung

2010

Status

Published

Herausgeber

S. Karger AG

Herausgeber URL

http://dx.doi.org/10.1159/000319707

Datum der Datenerfassung

2022

Titel

Ausgabe der Zeitschrift

Datenquelle: Crossref

Abstract

<h4>Background</h4>A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence.<h4>Aim</h4>To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention.<h4>Methods</h4>Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy.<h4>Results</h4>We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction.<h4>Conclusion</h4>This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.

Addresses

Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.

Autoren

Fabian Springer
Huu Phuc Nguyen
Jürgen Machann
Roland Schweizer
Michael B Ranke
Gerhard Binder
Fritz Schick
Stefan Ehehalt
DISKUS Study Group

DOI

10.1159/000319707

eISSN

1663-2826

Externe Identifier

PubMed Identifier: 20847546

Open access

false

ISSN

1663-2818

Ausgabe der Veröffentlichung

Zeitschrift

Hormone research in paediatrics

Schlüsselwörter

DISKUS Study Group
Adipose Tissue
Humans
Fatty Liver
Acanthosis Nigricans
Insulin Resistance
Choristoma
Body Weight
Body Mass Index
Waist-Hip Ratio
Diet
Motor Activity
Life Style
Puberty
Adolescent
Female

Sprache

eng

Medium

Print-Electronic

Online publication date

2010

Paginierung

376 - 380

Datum der Veröffentlichung

2010

Status

Published

Datum der Datenerfassung

2010

Titel

Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis: evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence.

Sub types

Journal Article
Case Reports

Ausgabe der Zeitschrift

Datenquelle: Europe PubMed Central

Abstract

BACKGROUND: A major factor in the development of insulin resistance is obesity. While the contribution of intrahepatic lipids to insulin resistance is well established in adults, there are only few reports in childhood and adolescence. AIM: To investigate the correlation between ectopic fat deposition and insulin sensitivity in a normal-weight girl with acanthosis nigricans before and after lifestyle intervention. METHODS: Variations in body fat composition and intrahepatic lipids were monitored by means of anthropometric measures and by means of methods based on magnetic resonance imaging and magnetic resonance spectroscopy. RESULTS: We present the case of a normal-weight 14-year-old Caucasian girl with pronounced hepatic steatosis together with acanthosis nigricans, increased waist-circumference and increased visceral fat. During a 7-month period of lifestyle intervention, the girl lost 7.1 kg in weight. Acanthosis nigricans, whole-body insulin sensitivity index (WBISI) and homeostasis model assessment (HOMA) improved significantly (before intervention: WBISI 0.42, HOMA 22.2; after intervention: WBISI 1.35, HOMA 6.9). Even though all lipid compartments were decreased in size, the intrahepatic lipids showed an extraordinarily great reduction. CONCLUSION: This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.

Date of acceptance

2010

Autoren

Fabian Springer
Huu Phuc Nguyen
Jürgen Machann
Roland Schweizer
Michael B Ranke
Gerhard Binder
Fritz Schick
Stefan Ehehalt
DISKUS Study Group

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/20847546

DOI

10.1159/000319707

eISSN

1663-2826

Ausgabe der Veröffentlichung

Zeitschrift

Horm Res Paediatr

Schlüsselwörter

Acanthosis Nigricans
Adipose Tissue
Adolescent
Body Mass Index
Body Weight
Choristoma
Diet
Fatty Liver
Female
Humans
Insulin Resistance
Life Style
Motor Activity
Puberty
Waist-Hip Ratio

Sprache

eng

Country

Switzerland

Paginierung

376 - 380

PII

000319707

Datum der Veröffentlichung

2010

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2011

Titel

Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis: evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence.

Sub types

Case Reports
Journal Article

Ausgabe der Zeitschrift

Datenquelle: PubMed

Beziehungen:

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Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis : evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence

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