Acute and repeated treatment with 5-PAHSA or 9-PAHSA isomers does not improve glucose control in mice

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Elsa Pflimlin
  • Maximilian Bielohuby
  • Marcus Korn
  • Kristin Breitschopf
  • Matthias Löhn
  • Paulus Wohlfart
  • Anish Konkar
  • Michael Podeschwa
  • Felix Bärenz
  • Anja Pfenninger
  • Uwe Schwahn
  • Till Opatz
  • Marcel Reimann
  • Stefan Petry
  • Norbert Tennagels
Sammlungen
  • metadata
ISSN
1932-7420
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell metabolism
Schlüsselwörter
  • 540 Chemie
  • 540 Chemistry and allied sciences
Sprache
eng
Paginierung
Seiten: 217 - 227
Datum der Veröffentlichung
2018
Herausgeber
Elsevier
Herausgeber URL
http://dx.doi.org/10.1016/j.cmet.2018.05.028
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Acute and repeated treatment with 5-PAHSA or 9-PAHSA isomers does not improve glucose control in mice
Ausgabe der Zeitschrift
28

Datenquelle: METADATA.UB

Andere Metadatenquellen:
Autoren
  • Elsa Pflimlin
  • Maximilian Bielohuby
  • Marcus Korn
  • Kristin Breitschopf
  • Matthias Loehn
  • Paulus Wohlfart
  • Anish Konkar
  • Michael Podeschwa
  • Felix Baerenz
  • Anja Pfenninger
  • Uwe Schwahn
  • Till Opatz
  • Marcel Reimann
  • Stefan Petry
  • Norbert Tennagels
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000440983900007&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.cmet.2018.05.028
eISSN
1932-7420
Externe Identifier
  • Clarivate Analytics Document Solution ID: GP6IW
  • PubMed Identifier: 29937376
ISSN
1550-4131
Ausgabe der Veröffentlichung
2
Zeitschrift
CELL METABOLISM
Paginierung
217 - +
Datum der Veröffentlichung
2018
Status
Published
Titel
Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
Sub types
  • Article
Ausgabe der Zeitschrift
28

Datenquelle: Web of Science (Lite)

Autoren
  • Elsa Pflimlin
  • Maximilian Bielohuby
  • Marcus Korn
  • Kristin Breitschopf
  • Matthias Löhn
  • Paulus Wohlfart
  • Anish Konkar
  • Michael Podeschwa
  • Felix Bärenz
  • Anja Pfenninger
  • Uwe Schwahn
  • Till Opatz
  • Marcel Reimann
  • Stefan Petry
  • Norbert Tennagels
DOI
10.1016/j.cmet.2018.05.028
ISSN
1550-4131
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell Metabolism
Sprache
en
Paginierung
217 - 227.e13
Datum der Veröffentlichung
2018
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.cmet.2018.05.028
Datum der Datenerfassung
2022
Titel
Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
Ausgabe der Zeitschrift
28

Datenquelle: Crossref

Abstract
Fatty acid esters of hydroxylated fatty acids (FAHFAs) were discovered as a novel class of endogenous mammalian lipids whose profound effects on metabolism have been shown. In the current study, in vitro and in vivo the metabolic effects of two of these FAHFAs, namely palmitic acid-5- (or -9) -hydroxy-stearic acid (5- or 9-PAHSA, respectively) were profiled. In DIO mice fed with differentially composed low- or high-fat diets, acute and subchronic treatment with 5-PAHSA and 9-PAHSA alone, or in combination, did not significantly improve the deranged metabolic status. Neither racemic 5- or 9-PAHSA, nor the enantiomers were able to: (1) increase basal or insulin-stimulated glucose uptake in vitro, (2) stimulate GLP-1 release from GLUTag cells, or (3) induce GSIS in rat, mouse, or human islets or in a human pancreatic β cell line. Therefore, our data do not support the further development of PAHSAs or their derivatives for the control of insulin resistance and hyperglycemia.
Addresses
  • Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Bldg. H821, 65926 Frankfurt am Main, Germany.
Autoren
  • Elsa Pflimlin
  • Maximilian Bielohuby
  • Marcus Korn
  • Kristin Breitschopf
  • Matthias Löhn
  • Paulus Wohlfart
  • Anish Konkar
  • Michael Podeschwa
  • Felix Bärenz
  • Anja Pfenninger
  • Uwe Schwahn
  • Till Opatz
  • Marcel Reimann
  • Stefan Petry
  • Norbert Tennagels
DOI
10.1016/j.cmet.2018.05.028
eISSN
1932-7420
Externe Identifier
  • PubMed Identifier: 29937376
Open access
false
ISSN
1550-4131
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell metabolism
Schlüsselwörter
  • Islets of Langerhans
  • Animals
  • Mice, Inbred C57BL
  • Humans
  • Mice
  • Rats
  • Rats, Sprague-Dawley
  • Hyperglycemia
  • Insulin Resistance
  • Obesity
  • Glucose
  • Palmitic Acid
  • Stearic Acids
  • Diet, Fat-Restricted
  • Models, Animal
  • Glucagon-Like Peptide 1
  • HEK293 Cells
  • Diet, High-Fat
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
217 - 227.e13
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
28

Datenquelle: Europe PubMed Central

Abstract
Fatty acid esters of hydroxylated fatty acids (FAHFAs) were discovered as a novel class of endogenous mammalian lipids whose profound effects on metabolism have been shown. In the current study, in vitro and in vivo the metabolic effects of two of these FAHFAs, namely palmitic acid-5- (or -9) -hydroxy-stearic acid (5- or 9-PAHSA, respectively) were profiled. In DIO mice fed with differentially composed low- or high-fat diets, acute and subchronic treatment with 5-PAHSA and 9-PAHSA alone, or in combination, did not significantly improve the deranged metabolic status. Neither racemic 5- or 9-PAHSA, nor the enantiomers were able to: (1) increase basal or insulin-stimulated glucose uptake in vitro, (2) stimulate GLP-1 release from GLUTag cells, or (3) induce GSIS in rat, mouse, or human islets or in a human pancreatic β cell line. Therefore, our data do not support the further development of PAHSAs or their derivatives for the control of insulin resistance and hyperglycemia.
Date of acceptance
2018
Autoren
  • Elsa Pflimlin
  • Maximilian Bielohuby
  • Marcus Korn
  • Kristin Breitschopf
  • Matthias Löhn
  • Paulus Wohlfart
  • Anish Konkar
  • Michael Podeschwa
  • Felix Bärenz
  • Anja Pfenninger
  • Uwe Schwahn
  • Till Opatz
  • Marcel Reimann
  • Stefan Petry
  • Norbert Tennagels
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29937376
DOI
10.1016/j.cmet.2018.05.028
eISSN
1932-7420
Ausgabe der Veröffentlichung
2
Zeitschrift
Cell Metab
Schlüsselwörter
  • PAHSA synthesis
  • diet-induced obesity (DIO)
  • hydroxylated fatty acids (FAHFAs)
  • insulin resistance
  • insulin sensitizer
  • type 2 diabetes (T2D)
  • Animals
  • Diet, Fat-Restricted
  • Diet, High-Fat
  • Glucagon-Like Peptide 1
  • Glucose
  • HEK293 Cells
  • Humans
  • Hyperglycemia
  • Insulin Resistance
  • Islets of Langerhans
  • Mice
  • Mice, Inbred C57BL
  • Models, Animal
  • Obesity
  • Palmitic Acid
  • Rats
  • Rats, Sprague-Dawley
  • Stearic Acids
Sprache
eng
Country
United States
Paginierung
217 - 227.e13
PII
S1550-4131(18)30381-4
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
28

Datenquelle: PubMed

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