Functional regulation of HIF-1alpha under normoxia - is there more than post-translational regulation?

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • A Kuschel
  • Perikles Simon
  • Suzan Tug
Sammlungen
  • metadata
ISSN
0021-9541
Ausgabe der Veröffentlichung
2
Zeitschrift
Journal of cellular physiology
Schlüsselwörter
  • 796 Sport
  • 796 Athletic and outdoor sports and games
Sprache
eng
Paginierung
Seiten: 514 - 524
Datum der Veröffentlichung
2012
Herausgeber URL
http://dx.doi.org/10.1002/jcp.22798
Datum der Datenerfassung
2020
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Zugang
Public
Titel
Functional regulation of HIF-1alpha under normoxia - is there more than post-translational regulation?
Ausgabe der Zeitschrift
227

Datenquelle: METADATA.UB

Andere Metadatenquellen:
Autoren
  • A Kuschel
  • P Simon
  • S Tug
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000298092800014&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/jcp.22798
eISSN
1097-4652
Externe Identifier
  • Clarivate Analytics Document Solution ID: 862LQ
  • PubMed Identifier: 21503885
ISSN
0021-9541
Ausgabe der Veröffentlichung
2
Zeitschrift
JOURNAL OF CELLULAR PHYSIOLOGY
Paginierung
514 - 524
Datum der Veröffentlichung
2012
Status
Published
Titel
Functional regulation of HIF-1a under normoxiauis there more than post-translational regulation?
Sub types
  • Review
Ausgabe der Zeitschrift
227

Datenquelle: Web of Science (Lite)

Abstract
<jats:title>Abstract</jats:title><jats:p>The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional activator playing a pivotal role in mammalian physiology and disease pathogenesis, e.g., HIF‐1 is indispensable in a broad range of developmental stages in different tumors. Its post‐translational regulation via PHDs under the influence of hypoxia is widely investigated and accepted. Different non‐hypoxic stimuli such as lipopolysaccharides (LPS), thrombin, and angiotensin II (Ang II), have been proven to enhance HIF‐1 levels through activation of regulative mechanisms distinct from protein stabilization. Some of these stimuli specifically regulate HIF‐1α at the transcriptional, post‐transcriptional, or translational level, whereas others additionally influence post‐translational modifications. Thus, it is difficult for the investigators to discern the impact of the different mechanisms leading to functional HIF‐1 protein. Nevertheless, profound knowledge of additional regulatory networks appears to depict new therapeutic opportunities and thus is an interesting and important field for further investigations. J. Cell. Physiol. 227: 514–524, 2012. © 2011 Wiley Periodicals, Inc.</jats:p>
Autoren
  • A Kuschel
  • P Simon
  • S Tug
DOI
10.1002/jcp.22798
eISSN
1097-4652
ISSN
0021-9541
Ausgabe der Veröffentlichung
2
Zeitschrift
Journal of Cellular Physiology
Sprache
en
Online publication date
2011
Paginierung
514 - 524
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/jcp.22798
Datum der Datenerfassung
2024
Titel
Functional regulation of HIF‐1α under normoxia—is there more than post‐translational regulation?
Ausgabe der Zeitschrift
227

Datenquelle: Crossref

Abstract
The hypoxia-inducible factor-1 (HIF-1) is an oxygen-regulated transcriptional activator playing a pivotal role in mammalian physiology and disease pathogenesis, e.g., HIF-1 is indispensable in a broad range of developmental stages in different tumors. Its post-translational regulation via PHDs under the influence of hypoxia is widely investigated and accepted. Different non-hypoxic stimuli such as lipopolysaccharides (LPS), thrombin, and angiotensin II (Ang II), have been proven to enhance HIF-1 levels through activation of regulative mechanisms distinct from protein stabilization. Some of these stimuli specifically regulate HIF-1α at the transcriptional, post-transcriptional, or translational level, whereas others additionally influence post-translational modifications. Thus, it is difficult for the investigators to discern the impact of the different mechanisms leading to functional HIF-1 protein. Nevertheless, profound knowledge of additional regulatory networks appears to depict new therapeutic opportunities and thus is an interesting and important field for further investigations.
Addresses
  • Department of Sports Medicine, Rehabilitation and Disease Prevention, Johannes-Gutenberg-University Mainz, Germany.
Autoren
  • A Kuschel
  • P Simon
  • S Tug
DOI
10.1002/jcp.22798
eISSN
1097-4652
Externe Identifier
  • PubMed Identifier: 21503885
Open access
false
ISSN
0021-9541
Ausgabe der Veröffentlichung
2
Zeitschrift
Journal of cellular physiology
Schlüsselwörter
  • Animals
  • Mammals
  • Oxygen
  • Gene Expression Regulation
  • Hypoxia-Inducible Factor 1, alpha Subunit
Sprache
eng
Medium
Print
Paginierung
514 - 524
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2011
Titel
Functional regulation of HIF-1α under normoxia--is there more than post-translational regulation?
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
227

Datenquelle: Europe PubMed Central

Abstract
The hypoxia-inducible factor-1 (HIF-1) is an oxygen-regulated transcriptional activator playing a pivotal role in mammalian physiology and disease pathogenesis, e.g., HIF-1 is indispensable in a broad range of developmental stages in different tumors. Its post-translational regulation via PHDs under the influence of hypoxia is widely investigated and accepted. Different non-hypoxic stimuli such as lipopolysaccharides (LPS), thrombin, and angiotensin II (Ang II), have been proven to enhance HIF-1 levels through activation of regulative mechanisms distinct from protein stabilization. Some of these stimuli specifically regulate HIF-1α at the transcriptional, post-transcriptional, or translational level, whereas others additionally influence post-translational modifications. Thus, it is difficult for the investigators to discern the impact of the different mechanisms leading to functional HIF-1 protein. Nevertheless, profound knowledge of additional regulatory networks appears to depict new therapeutic opportunities and thus is an interesting and important field for further investigations.
Autoren
  • A Kuschel
  • P Simon
  • S Tug
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21503885
DOI
10.1002/jcp.22798
eISSN
1097-4652
Ausgabe der Veröffentlichung
2
Zeitschrift
J Cell Physiol
Schlüsselwörter
  • Animals
  • Gene Expression Regulation
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Mammals
  • Oxygen
Sprache
eng
Country
United States
Paginierung
514 - 524
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Functional regulation of HIF-1α under normoxia--is there more than post-translational regulation?
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
227

Datenquelle: PubMed

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