Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

Autoren

Xiaodong Fang
Eviatar Nevo
Lijuan Han
Erez Y Levanon
Jing Zhao
Aaron Avivi
Denis Larkin
Xuanting Jiang
Sergey Feranchuk
Yabing Zhu
Alla Fishman
Yue Feng
Noa Sher
Zhiqiang Xiong
Thomas Hankeln
Zhiyong Huang
Vera Gorbunova
Lu Zhang
Wei Zhao
Derek E Wildman
Yingqi Xiong
Andrei Gudkov
Qiumei Zheng
Gideon Rechavi
Sanyang Liu
Lily Bazak
Jie Chen
Binyamin A Knisbacher
Yao Lu
Imad Shams
Krzysztof Gajda
Marta Farre
Jaebum Kim
Harris A Lewin
Jian Ma
Mark Band
Anne Bicker
Angela Kranz
Tobias Mattheus
Hanno Schmidt
Andrei Seluanov
Jorge Azpurua
Michael R McGowen
Eshel Ben Jacob
Kexin Li
Shaoliang Peng
Xiaoqian Zhu
Xiangke Liao
Shuaicheng Li
Anders Krogh
Xin Zhou
Leonid Brodsky
Jun Wang

Autoren-URL

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000338830400002&DestLinkType=FullRecord&DestApp=WOS_CPL

DOI

10.1038/ncomms4966

Externe Identifier

Clarivate Analytics Document Solution ID: AL0QA
PubMed Identifier: 24892994

ISSN

2041-1723

Zeitschrift

NATURE COMMUNICATIONS

Artikelnummer

ARTN 3966

Datum der Veröffentlichung

2014

Status

Published

Titel

Genome-wide adaptive complexes to underground stresses in blind mole rats <i>Spalax</i>

Sub types

Article

Ausgabe der Zeitschrift

5

Datenquelle: Web of Science (Lite)

Autoren

Xiaodong Fang
Eviatar Nevo
Lijuan Han
Erez Y Levanon
Jing Zhao
Aaron Avivi
Denis Larkin
Xuanting Jiang
Sergey Feranchuk
Yabing Zhu
Alla Fishman
Yue Feng
Noa Sher
Zhiqiang Xiong
Thomas Hankeln
Zhiyong Huang
Vera Gorbunova
Lu Zhang
Wei Zhao
Derek E Wildman
Yingqi Xiong
Andrei Gudkov
Qiumei Zheng
Gideon Rechavi
Sanyang Liu
Lily Bazak
Jie Chen
Binyamin A Knisbacher
Yao Lu
Imad Shams
Krzysztof Gajda
Marta Farré
Jaebum Kim
Harris A Lewin
Jian Ma
Mark Band
Anne Bicker
Angela Kranz
Tobias Mattheus
Hanno Schmidt
Andrei Seluanov
Jorge Azpurua
Michael R McGowen
Eshel Ben Jacob
Kexin Li
Shaoliang Peng
Xiaoqian Zhu
Xiangke Liao
Shuaicheng Li
Anders Krogh
Xin Zhou
Leonid Brodsky
Jun Wang

DOI

10.1038/ncomms4966

eISSN

2041-1723

Ausgabe der Veröffentlichung

1

Zeitschrift

Nature Communications

Sprache

en

Artikelnummer

3966

Online publication date

2014

Status

Published online

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1038/ncomms4966

Datum der Datenerfassung

2023

Titel

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

Ausgabe der Zeitschrift

5

Datenquelle: Crossref

Abstract

The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degeneration of vision and progression of photoperiodic perception, tolerance to hypercapnia and hypoxia and resistance to cancer. The remarkable traits of the BMR, together with its genomic and transcriptomic information, enhance our understanding of adaptation to extreme environments and will enable the utilization of BMR models for biomedical research in the fight against cancer, stroke and cardiovascular diseases.

Addresses

1] BGI-Tech, BGI-Shenzhen, Shenzhen 518083, China [2] Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

Autoren

Xiaodong Fang
Eviatar Nevo
Lijuan Han
Erez Y Levanon
Jing Zhao
Aaron Avivi
Denis Larkin
Xuanting Jiang
Sergey Feranchuk
Yabing Zhu
Alla Fishman
Yue Feng
Noa Sher
Zhiqiang Xiong
Thomas Hankeln
Zhiyong Huang
Vera Gorbunova
Lu Zhang
Wei Zhao
Derek E Wildman
Yingqi Xiong
Andrei Gudkov
Qiumei Zheng
Gideon Rechavi
Sanyang Liu
Lily Bazak
Jie Chen
Binyamin A Knisbacher
Yao Lu
Imad Shams
Krzysztof Gajda
Marta Farré
Jaebum Kim
Harris A Lewin
Jian Ma
Mark Band
Anne Bicker
Angela Kranz
Tobias Mattheus
Hanno Schmidt
Andrei Seluanov
Jorge Azpurua
Michael R McGowen
Eshel Ben Jacob
Kexin Li
Shaoliang Peng
Xiaoqian Zhu
Xiangke Liao
Shuaicheng Li
Anders Krogh
Xin Zhou
Leonid Brodsky
Jun Wang
Jun Wang

DOI

10.1038/ncomms4966

eISSN

2041-1723

Externe Identifier

PubMed Identifier: 24892994

Funding acknowledgements

Biotechnology and Biological Sciences Research Council: BB/J010170/2
NIA NIH HHS: P01 AG047200
Biotechnology and Biological Sciences Research Council: BB/J010170/1

Open access

false

ISSN

2041-1723

Zeitschrift

Nature communications

Schlüsselwörter

Animals
Spalax
Hypercapnia
Gene Expression Profiling
Adaptation, Physiological
Evolution, Molecular
RNA Editing
Short Interspersed Nucleotide Elements
Genome
Darkness
Stress, Physiological
Transcriptome
Hypoxia

Sprache

eng

Medium

Electronic

Online publication date

2014

Paginierung

3966

Datum der Veröffentlichung

2014

Status

Published

Datum der Datenerfassung

2014

Titel

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

5

Datenquelle: Europe PubMed Central

Abstract

The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degeneration of vision and progression of photoperiodic perception, tolerance to hypercapnia and hypoxia and resistance to cancer. The remarkable traits of the BMR, together with its genomic and transcriptomic information, enhance our understanding of adaptation to extreme environments and will enable the utilization of BMR models for biomedical research in the fight against cancer, stroke and cardiovascular diseases.

Date of acceptance

2014

Autoren

Xiaodong Fang
Eviatar Nevo
Lijuan Han
Erez Y Levanon
Jing Zhao
Aaron Avivi
Denis Larkin
Xuanting Jiang
Sergey Feranchuk
Yabing Zhu
Alla Fishman
Yue Feng
Noa Sher
Zhiqiang Xiong
Thomas Hankeln
Zhiyong Huang
Vera Gorbunova
Lu Zhang
Wei Zhao
Derek E Wildman
Yingqi Xiong
Andrei Gudkov
Qiumei Zheng
Gideon Rechavi
Sanyang Liu
Lily Bazak
Jie Chen
Binyamin A Knisbacher
Yao Lu
Imad Shams
Krzysztof Gajda
Marta Farré
Jaebum Kim
Harris A Lewin
Jian Ma
Mark Band
Anne Bicker
Angela Kranz
Tobias Mattheus
Hanno Schmidt
Andrei Seluanov
Jorge Azpurua
Michael R McGowen
Eshel Ben Jacob
Kexin Li
Shaoliang Peng
Xiaoqian Zhu
Xiangke Liao
Shuaicheng Li
Anders Krogh
Xin Zhou
Leonid Brodsky
Jun Wang

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/24892994

DOI

10.1038/ncomms4966

eISSN

2041-1723

Funding acknowledgements

NIA NIH HHS: P01 AG047200
Biotechnology and Biological Sciences Research Council: BB/J010170/1

Zeitschrift

Nat Commun

Schlüsselwörter

Adaptation, Physiological
Animals
Darkness
Evolution, Molecular
Gene Expression Profiling
Genome
Hypercapnia
Hypoxia
RNA Editing
Short Interspersed Nucleotide Elements
Spalax
Stress, Physiological
Transcriptome

Sprache

eng

Country

England

Paginierung

3966

PII

ncomms4966

Datum der Veröffentlichung

2014

Status

Published online

Datum, an dem der Datensatz öffentlich gemacht wurde

2015

Titel

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

5

Datenquelle: PubMed

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

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