Association of SGK1 gene polymorphisms with type 2 diabetes

Autoren

Matthias Schwab
Adrian Lupescu
Maria Mota
Eugen Mota
Andreas Frey
Perikles Simon
Peter R Mertens
Juergen Floege
Friedrich Luft
Steven Asante-Poku
Elke Schaeffeler
Florian Lang

Autoren-URL

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000252589900016&DestLinkType=FullRecord&DestApp=WOS_CPL

DOI

10.1159/000113757

eISSN

1421-9778

Externe Identifier

Clarivate Analytics Document Solution ID: 254ME
PubMed Identifier: 18209482

ISSN

1015-8987

Ausgabe der Veröffentlichung

1-3

Zeitschrift

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Schlüsselwörter

SGK1
type 2 diabetes
blood pressure
obesity
hypertension

Paginierung

151 - 160

Datum der Veröffentlichung

2008

Status

Published

Titel

Association of SGK1 gene polymorphisms with type 2 diabetes

Sub types

Article

Ausgabe der Zeitschrift

21

Datenquelle: Web of Science (Lite)

Autoren

Matthias Schwab
Adrian Lupescu
Maria Mota
Eugen Mota
Andreas Frey
Perikles Simon
Peter R Mertens
Jürgen Floege
Friedrich Luft
Steven Asante-Poku
Elke Schaeffeler
Florian Lang

DOI

10.1159/000113757

eISSN

1421-9778

ISSN

1015-8987

Ausgabe der Veröffentlichung

1-3

Zeitschrift

Cellular Physiology and Biochemistry

Sprache

en

Online publication date

2008

Paginierung

151 - 160

Datum der Veröffentlichung

2008

Status

Published

Herausgeber

S. Karger AG

Herausgeber URL

http://dx.doi.org/10.1159/000113757

Datum der Datenerfassung

2021

Titel

Association of SGK1 Gene Polymorphisms with Type 2 Diabetes

Ausgabe der Zeitschrift

21

Datenquelle: Crossref

Abstract

The serum and glucocorticoid inducible kinase SGK1 is genomically upregulated by glucocorticoids and in turn stimulates a variety of carriers and channels including the renal epithelial Na(+) channel ENaC and the intestinal Na(+) glucose transporter SGLT1. Twin studies disclosed an association of a specific SGK1 haplotype with moderately enhanced blood pressure in individuals who are carrying simultaneously a homozygous genotype for a variant in intron 6 [I6CC] and a homozygous or heterozygous genotype for the C allele of a polymorphism in exon 8 [E8CC/CT] of the SGK1 gene. A subsequent study confirmed the impact of this risk haplotype on blood pressure. SGK1 knockout mice are resistant to the insulin and high salt induced increase of blood pressure, glucocorticoid induced increase of electrogenic glucose transport, and glucocorticoid induced suppression of insulin release. The present study explored whether the I6CC/E8CC/CT haplotype impacts on the prevalence of type 2 diabetes. The prevalence of the I6CC genotype was 3.1% in a healthy German, 2.4 % in a healthy Romanian and 11.6 % in a healthy African population from Ghana (p=0.0006 versus prevalence in Caucasians). Comparison of genotype frequencies between type 2 diabetic patients and the respective control groups revealed significant differences for the intron 6 T>C variant. Carriers of at least one T allele were protected against type 2 diabetes (Romanians: p=0.023; OR 0.29; 95% CI 0.09-0.89; Germans: p=0.01; OR 0.37; 95% CI 0.17-0.81). The SGK1 risk haplotype (I6CC/E8CC/CT) was significantly (p=0.032; OR 4.31, 95% CI 1.19-15.58) more frequent in diabetic patients (7.2 %) than in healthy volunteers from Romania (1.8%). The observations support the view that SGK-1 may participate in the pathogenesis of metabolic syndrome.

Addresses

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

Autoren

Matthias Schwab
Adrian Lupescu
Maria Mota
Eugen Mota
Andreas Frey
Perikles Simon
Peter R Mertens
Jurgen Floege
Friedrich Luft
Steven Asante-Poku
Elke Schaeffeler
Florian Lang

DOI

10.1159/000113757

eISSN

1421-9778

Externe Identifier

PubMed Identifier: 18209482

Open access

false

ISSN

1015-8987

Ausgabe der Veröffentlichung

1-3

Zeitschrift

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Schlüsselwörter

Humans
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Immediate-Early Proteins
Case-Control Studies
Mutation
Polymorphism, Genetic
Alleles
Adult
Middle Aged
Female
Male
Protein Serine-Threonine Kinases

Sprache

eng

Medium

Print-Electronic

Online publication date

2008

Paginierung

151 - 160

Datum der Veröffentlichung

2008

Status

Published

Datum der Datenerfassung

2008

Titel

Association of SGK1 gene polymorphisms with type 2 diabetes.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

21

Datenquelle: Europe PubMed Central

Abstract

The serum and glucocorticoid inducible kinase SGK1 is genomically upregulated by glucocorticoids and in turn stimulates a variety of carriers and channels including the renal epithelial Na(+) channel ENaC and the intestinal Na(+) glucose transporter SGLT1. Twin studies disclosed an association of a specific SGK1 haplotype with moderately enhanced blood pressure in individuals who are carrying simultaneously a homozygous genotype for a variant in intron 6 [I6CC] and a homozygous or heterozygous genotype for the C allele of a polymorphism in exon 8 [E8CC/CT] of the SGK1 gene. A subsequent study confirmed the impact of this risk haplotype on blood pressure. SGK1 knockout mice are resistant to the insulin and high salt induced increase of blood pressure, glucocorticoid induced increase of electrogenic glucose transport, and glucocorticoid induced suppression of insulin release. The present study explored whether the I6CC/E8CC/CT haplotype impacts on the prevalence of type 2 diabetes. The prevalence of the I6CC genotype was 3.1% in a healthy German, 2.4 % in a healthy Romanian and 11.6 % in a healthy African population from Ghana (p=0.0006 versus prevalence in Caucasians). Comparison of genotype frequencies between type 2 diabetic patients and the respective control groups revealed significant differences for the intron 6 T>C variant. Carriers of at least one T allele were protected against type 2 diabetes (Romanians: p=0.023; OR 0.29; 95% CI 0.09-0.89; Germans: p=0.01; OR 0.37; 95% CI 0.17-0.81). The SGK1 risk haplotype (I6CC/E8CC/CT) was significantly (p=0.032; OR 4.31, 95% CI 1.19-15.58) more frequent in diabetic patients (7.2 %) than in healthy volunteers from Romania (1.8%). The observations support the view that SGK-1 may participate in the pathogenesis of metabolic syndrome.

Date of acceptance

2007

Autoren

Matthias Schwab
Adrian Lupescu
Maria Mota
Eugen Mota
Andreas Frey
Perikles Simon
Peter R Mertens
Jurgen Floege
Friedrich Luft
Steven Asante-Poku
Elke Schaeffeler
Florian Lang

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/18209482

DOI

10.1159/000113757

ISSN

1015-8987

Ausgabe der Veröffentlichung

1-3

Zeitschrift

Cell Physiol Biochem

Schlüsselwörter

Adult
Alleles
Case-Control Studies
Diabetes Mellitus, Type 2
Female
Genetic Predisposition to Disease
Humans
Immediate-Early Proteins
Male
Middle Aged
Mutation
Polymorphism, Genetic
Protein Serine-Threonine Kinases

Sprache

eng

Country

Germany

Paginierung

151 - 160

PII

000113757

Datum der Veröffentlichung

2008

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2008

Titel

Association of SGK1 gene polymorphisms with type 2 diabetes.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

21

Datenquelle: PubMed

Association of SGK1 gene polymorphisms with type 2 diabetes

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