The protein structure context of polyQ regions
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Franziska Totzeck
- Miguel Andrade
- Pablo Mier
- Sammlungen
- metadata
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- PLoS one
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Notes
- Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.
- Paginierung
- e0170801
- Datum der Veröffentlichung
- 2017
- Herausgeber
- PLoS
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0170801
- Datum der Datenerfassung
- 2020
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Zugang
- Public
- Titel
- The protein structure context of polyQ regions
- Ausgabe der Zeitschrift
- 12
Datenquelle: METADATA.UB
- Andere Metadatenquellen:
-
- Autoren
- Franziska Totzeck
- Miguel A Andrade-Navarro
- Pablo Mier
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000396176100047&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1371/journal.pone.0170801
- Externe Identifier
- Clarivate Analytics Document Solution ID: EN7IT
- PubMed Identifier: 28125688
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- PLOS ONE
- Artikelnummer
- ARTN e0170801
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Titel
- The Protein Structure Context of PolyQ Regions
- Sub types
- Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: Web of Science (Lite)
- Autoren
- Franziska Totzeck
- Miguel A Andrade-Navarro
- Pablo Mier
- DOI
- 10.1371/journal.pone.0170801
- Editoren
- Patrick van der Wel
- eISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- PLOS ONE
- Sprache
- en
- Online publication date
- 2017
- Paginierung
- e0170801 - e0170801
- Status
- Published online
- Herausgeber
- Public Library of Science (PLoS)
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0170801
- Datum der Datenerfassung
- 2018
- Titel
- The Protein Structure Context of PolyQ Regions
- Ausgabe der Zeitschrift
- 12
Datenquelle: Crossref
- Abstract
- Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by analysing the secondary structure of polyQ proteins and their homologs. The results revealed that the secondary structure in polyQ vicinity is predominantly random coil or helix. Importantly, the regions surrounding the polyQ are often not solved in 3D structures. In the few cases where the point of insertion of the polyQ was mapped to a full protein, we observed that these are always located in the surface of the protein. The findings support the hypothesis that polyQ might serve to extend coiled coils at their C-terminus in highly disordered regions involved in protein-protein interactions.
- Addresses
- Faculty of Biology, Johannes Gutenberg University Mainz, Gresemundweg 2, Mainz, Germany.
- Autoren
- Franziska Totzeck
- Miguel A Andrade-Navarro
- Pablo Mier
- DOI
- 10.1371/journal.pone.0170801
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Identifier: 28125688
- PubMed Central ID: PMC5268486
- Open access
- true
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- PloS one
- Schlüsselwörter
- Humans
- Saccharomyces cerevisiae
- Peptides
- Saccharomyces cerevisiae Proteins
- Nerve Tissue Proteins
- Models, Molecular
- Databases, Protein
- Protein Interaction Domains and Motifs
- Mediator Complex
- Protein Conformation, alpha-Helical
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2017
- Open access status
- Open Access
- Paginierung
- e0170801
- Datum der Veröffentlichung
- 2017
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2017
- Titel
- The Protein Structure Context of PolyQ Regions.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 12
Files
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170801&type=printable https://europepmc.org/articles/PMC5268486?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by analysing the secondary structure of polyQ proteins and their homologs. The results revealed that the secondary structure in polyQ vicinity is predominantly random coil or helix. Importantly, the regions surrounding the polyQ are often not solved in 3D structures. In the few cases where the point of insertion of the polyQ was mapped to a full protein, we observed that these are always located in the surface of the protein. The findings support the hypothesis that polyQ might serve to extend coiled coils at their C-terminus in highly disordered regions involved in protein-protein interactions.
- Date of acceptance
- 2017
- Autoren
- Franziska Totzeck
- Miguel A Andrade-Navarro
- Pablo Mier
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/28125688
- DOI
- 10.1371/journal.pone.0170801
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Central ID: PMC5268486
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- PLoS One
- Schlüsselwörter
- Databases, Protein
- Humans
- Mediator Complex
- Models, Molecular
- Nerve Tissue Proteins
- Peptides
- Protein Conformation, alpha-Helical
- Protein Interaction Domains and Motifs
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sprache
- eng
- Country
- United States
- Paginierung
- e0170801
- PII
- PONE-D-16-36260
- Datum der Veröffentlichung
- 2017
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2017
- Titel
- The Protein Structure Context of PolyQ Regions.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 12
Datenquelle: PubMed
- Author's licence
- CC-BY
- Autoren
- Franziska Totzeck
- Miguel Andrade
- Pablo Mier
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-OA-Publizieren (2012 - 2017)
- Resource version
- Published version
- DOI
- 10.1371/journal.pone.0170801
- Funding acknowledgements
- DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- PLoS one
- Schlüsselwörter
- 570 Biowissenschaften
- 570 Life sciences
- Sprache
- eng
- Notes
- Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.
- Open access status
- Open Access
- Paginierung
- e0170801
- Datum der Veröffentlichung
- 2017
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/7758
- Herausgeber
- PLoS
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0170801
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- The protein structure context of polyQ regions
- Ausgabe der Zeitschrift
- 12
Files
the_protein_structure_context-20220913185143669.pdf
Datenquelle: OPENSCIENCE.UB
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